| 1 | Wed Oct 25 | at Knicks | W108-104 | 1-0 | 1.000 | Madison Square Garden · Manhattan, NY |
| 2 | Fri Oct 27 | vs Heat | W119-111 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Mon Oct 30 | at Wizards | W126-107 | 3-0 | 1.000 | Capital One Arena · Washington, D.C. |
| 4 | Wed Nov 1 | vs Pacers | W155-104 | 4-0 | 1.000 | TD Garden · Boston, MA |
| 5 | Sat Nov 4 | at Nets | W124-114 | 5-0 | 1.000 | Barclays Center · Brooklyn, NY |
| 6 | Mon Nov 6 | at T-wolves | L109-114 (OT) | 5-1 | .833 | Target Center · Minneapolis, MN |
| 7 | Wed Nov 8 | at 76ers | L103-106 | 5-2 | .714 | Wells Fargo Center · Philadelphia, PA |
| 8 | Fri Nov 10 | vsNets | W121-107 | 6-2 | .750 | TD Garden · Boston, MA |
| 9 | Sat Nov 11 | vs Raptors | W117-94 | 7-2 | .778 | TD Garden · Boston, MA |
| 10 | Mon Nov 13 | vsKnicks | W114-98 | 8-2 | .800 | TD Garden · Boston, MA |
| 11 | Wed Nov 15 | at76ers | W117-107 | 9-2 | .818 | Wells Fargo Center · Philadelphia, PA |
| 12 | Fri Nov 17 | atRaptors | W108-105 | 10-2 | .833 | Scotiabank Arena · Toronto, ON |
| 13 | Sun Nov 19 | at Grizzlies | W102-100 | 11-2 | .846 | FedExForum · Memphis, TN |
| 14 | Mon Nov 20 | at Hornets | L118-121 (OT) | 11-3 | .786 | Spectrum Center · Charlotte, NC |
| 15 | Wed Nov 22 | vs Bucks | W119-116 | 12-3 | .800 | TD Garden · Boston, MA |
| 16 | Fri Nov 24 | at Magic | L96-113 | 12-4 | .750 | Amway Center · Orlando, FL |
| 17 | Sun Nov 26 | vs Hawks | W113-103 | 13-4 | .765 | TD Garden · Boston, MA |
| 18 | Tue Nov 28 | vs Bulls | W124-97 | 14-4 | .778 | TD Garden · Boston, MA |
| 19 | Fri Dec 1 | vs76ers | W125-119 | 15-4 | .789 | TD Garden · Boston, MA |
| 20 | Mon Dec 4 | atPacers | L112-122 | 15-5 | .750 | Gainbridge Fieldhouse · Indianapolis, IN |
| 21 | Fri Dec 8 | vsKnicks | W133-123 | 16-5 | .762 | TD Garden · Boston, MA |
| 22 | Tue Dec 12 | vs Cavaliers | W120-113 | 17-5 | .773 | TD Garden · Boston, MA |
| 23 | Thu Dec 14 | vsCavaliers | W116-107 | 18-5 | .783 | TD Garden · Boston, MA |
| 24 | Fri Dec 15 | vsMagic | W128-111 | 19-5 | .792 | TD Garden · Boston, MA |
| 25 | Sun Dec 17 | vsMagic | W114-97 | 20-5 | .800 | TD Garden · Boston, MA |
| 26 | Tue Dec 19 | at Warriors | L126-132 (OT) | 20-6 | .769 | Chase Center · San Francisco, CA |
| 27 | Wed Dec 20 | at Kings | W144-119 | 21-6 | .778 | Golden 1 Center · Sacramento, CA |
| 28 | Sat Dec 23 | at Clippers | W145-108 | 22-6 | .786 | Crypto.com Arena · Los Angeles, CA |
| 29 | Mon Dec 25 | at Lakers | W126-115 | 23-6 | .793 | Crypto.com Arena · Los Angeles, CA |
| 30 | Thu Dec 28 | vs Pistons | W128-122 (OT) | 24-6 | .800 | TD Garden · Boston, MA |
| 31 | Fri Dec 29 | vsRaptors | W120-118 | 25-6 | .806 | TD Garden · Boston, MA |
| 32 | Sun Dec 31 | at Spurs | W134-101 | 26-6 | .813 | AT&T Center · San Antonio, TX |
| 33 | Tue Jan 2 | at Thunder | L123-127 | 26-7 | .788 | Paycom Center · Oklahoma City, OK |
| 34 | Fri Jan 5 | vs Jazz | W126-97 | 27-7 | .794 | TD Garden · Boston, MA |
| 35 | Sat Jan 6 | atPacers | W118-101 | 28-7 | .800 | Gainbridge Fieldhouse · Indianapolis, IN |
| 36 | Mon Jan 8 | atPacers | L131-133 | 28-8 | .778 | Gainbridge Fieldhouse · Indianapolis, IN |
| 37 | Wed Jan 10 | vsT-wolves | W127-120 (OT) | 29-8 | .784 | TD Garden · Boston, MA |
| 38 | Thu Jan 11 | atBucks | L102-135 | 29-9 | .763 | Fiserv Forum · Milwaukee, WI |
| 39 | Sat Jan 13 | vs Rockets | W145-113 | 30-9 | .769 | TD Garden · Boston, MA |
| 40 | Mon Jan 15 | atRaptors | W105-96 | 31-9 | .775 | Scotiabank Arena · Toronto, ON |
| 41 | Wed Jan 17 | vsSpurs | W117-98 | 32-9 | .780 | TD Garden · Boston, MA |
| 42 | Fri Jan 19 | vs Nuggets | L100-102 | 32-10 | .762 | TD Garden · Boston, MA |
| 43 | Sun Jan 21 | atRockets | W116-107 | 33-10 | .767 | Toyota Center · Houston, TX |
| 44 | Mon Jan 22 | at Mavericks | W119-110 | 34-10 | .773 | American Airlines Center · Dallas, TX |
| 45 | Thu Jan 25 | atHeat | W143-110 | 35-10 | .778 | FTX Arena · Miami, FL |
| 46 | Sat Jan 27 | vsClippers | L96-115 | 35-11 | .761 | TD Garden · Boston, MA |
| 47 | Mon Jan 29 | vs Pelicans | W118-112 | 36-11 | .766 | TD Garden · Boston, MA |
| 48 | Tue Jan 30 | vsPacers | W129-124 | 37-11 | .771 | TD Garden · Boston, MA |
| 49 | Thu Feb 1 | vsLakers | L105-114 | 37-12 | .755 | TD Garden · Boston, MA |
| 50 | Sun Feb 4 | vsGrizzlies | W131-91 | 38-12 | .760 | TD Garden · Boston, MA |
| 51 | Wed Feb 7 | vsHawks | W125-117 | 39-12 | .765 | TD Garden · Boston, MA |
| 52 | Fri Feb 9 | vsWizards | W133-129 | 40-12 | .769 | TD Garden · Boston, MA |
| 53 | Sun Feb 11 | atHeat | W110-106 | 41-12 | .774 | FTX Arena · Miami, FL |
| 54 | Tue Feb 13 | atNets | W118-110 | 42-12 | .778 | Barclays Center · Brooklyn, NY |
| 55 | Wed Feb 14 | vsNets | W136-86 | 43-12 | .782 | TD Garden · Boston, MA |
| 56 | Thu Feb 22 | atBulls | W129-112 | 44-12 | .786 | United Center · Chicago, IL |
| 57 | Sat Feb 24 | atKnicks | W116-102 | 45-12 | .789 | Madison Square Garden · Manhattan, NY |
| 58 | Tue Feb 27 | vs76ers | W117-99 | 46-12 | .793 | TD Garden · Boston, MA |
| 59 | Fri Mar 1 | vsMavericks | W138-110 | 47-12 | .797 | TD Garden · Boston, MA |
| 60 | Sun Mar 3 | vsWarriors | W140-88 | 48-12 | .800 | TD Garden · Boston, MA |
| 61 | Tue Mar 5 | atCavaliers | L104-105 | 48-13 | .787 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 62 | Thu Mar 7 | atNuggets | L109-115 | 48-14 | .774 | Ball Arena · Denver, CO |
| 63 | Sat Mar 9 | at Suns | W117-107 | 49-14 | .778 | Footprint Center · Phoenix, AZ |
| 64 | Mon Mar 11 | at Blazers | W121-99 | 50-14 | .781 | Moda Center · Portland, OR |
| 65 | Tue Mar 12 | atJazz | W123-107 | 51-14 | .785 | Vivint Arena · Salt Lake City, UT |
| 66 | Thu Mar 14 | vsSuns | W127-112 | 52-14 | .788 | TD Garden · Boston, MA |
| 67 | Sun Mar 17 | atWizards | W130-104 | 53-14 | .791 | Capital One Arena · Washington, D.C. |
| 68 | Mon Mar 18 | vsPistons | W119-94 | 54-14 | .794 | TD Garden · Boston, MA |
| 69 | Wed Mar 20 | vsBucks | W122-119 | 55-14 | .797 | TD Garden · Boston, MA |
| 70 | Fri Mar 22 | atPistons | W129-102 | 56-14 | .800 | Little Caesars Arena · Detroit, MI |
| 71 | Sat Mar 23 | atBulls | W124-113 | 57-14 | .803 | United Center · Chicago, IL |
| 72 | Mon Mar 25 | atHawks | L118-120 | 57-15 | .792 | State Farm Arena · Atlanta, GA |
| 73 | Thu Mar 28 | atHawks | L122-123 (OT) | 57-16 | .781 | State Farm Arena · Atlanta, GA |
| 74 | Sat Mar 30 | atPelicans | W104-92 | 58-16 | .784 | Smoothie King Center · New Orleans, LA |
| 75 | Mon Apr 1 | atHornets | W118-104 | 59-16 | .787 | Spectrum Center · Charlotte, NC |
| 76 | Wed Apr 3 | vsThunder | W135-100 | 60-16 | .789 | TD Garden · Boston, MA |
| 77 | Fri Apr 5 | vsKings | W101-100 | 61-16 | .792 | TD Garden · Boston, MA |
| 78 | Sun Apr 7 | vsBlazers | W124-107 | 62-16 | .795 | TD Garden · Boston, MA |
| 79 | Tue Apr 9 | atBucks | L91-104 | 62-17 | .785 | Fiserv Forum · Milwaukee, WI |
| 80 | Thu Apr 11 | vsKnicks | L109-118 | 62-18 | .775 | TD Garden · Boston, MA |
| 81 | Fri Apr 12 | vsHornets | W131-98 | 63-18 | .778 | TD Garden · Boston, MA |
| 82 | Sun Apr 14 | vsWizards | W132-122 | 64-18 | .780 | TD Garden · Boston, MA |
| 1 | Sun Apr 21 | vsHeat | W114-94 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Wed Apr 24 | vsHeat | L101-111 | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Sat Apr 27 | atHeat | W104-84 | 2-1 | .667 | FTX Arena · Miami, FL |
| 4 | Mon Apr 29 | atHeat | W102-88 | 3-1 | .750 | FTX Arena · Miami, FL |
| 5 | Wed May 1 | vsHeat | W118-84 | 4-1 | .800 | TD Garden · Boston, MA |
| 1 | Tue May 7 | vsCavaliers | W120-95 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Thu May 9 | vsCavaliers | L94-118 | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Sat May 11 | atCavaliers | W106-93 | 2-1 | .667 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 4 | Mon May 13 | atCavaliers | W109-102 | 3-1 | .750 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 5 | Wed May 15 | vsCavaliers | W113-98 | 4-1 | .800 | TD Garden · Boston, MA |
| 1 | Tue May 21 | vsPacers | W133-128 (OT) | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Thu May 23 | vsPacers | W126-110 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Sat May 25 | atPacers | W114-111 | 3-0 | 1.000 | Gainbridge Fieldhouse · Indianapolis, IN |
| 4 | Mon May 27 | atPacers | W105-102 | 4-0 | 1.000 | Gainbridge Fieldhouse · Indianapolis, IN |
| 1 | Thu Jun 6 | vsMavericks | W107-89 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Sun Jun 9 | vsMavericks | W105-98 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Wed Jun 12 | atMavericks | W106-99 | 3-0 | 1.000 | American Airlines Center · Dallas, TX |
| 4 | Fri Jun 14 | atMavericks | L84-122 | 3-1 | .750 | American Airlines Center · Dallas, TX |
| 5 | Mon Jun 17 | vsMavericks | W106-88 | 4-1 | .800 | TD Garden · Boston, MA |
