| 1 | Tue Oct 17 | at Cavaliers | L99-102 | 0-1 | .000 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 2 | Wed Oct 18 | vs Bucks | L100-108 | 0-2 | .000 | TD Garden · Boston, MA |
| 3 | Fri Oct 20 | at 76ers | W102-92 | 1-2 | .333 | Wells Fargo Center · Philadelphia, PA |
| 4 | Tue Oct 24 | vs Knicks | W110-89 | 2-2 | .500 | TD Garden · Boston, MA |
| 5 | Thu Oct 26 | atBucks | W96-89 | 3-2 | .600 | Fiserv Forum · Milwaukee, WI |
| 6 | Sat Oct 28 | at Heat | W96-90 | 4-2 | .667 | FTX Arena · Miami, FL |
| 7 | Mon Oct 30 | vs Spurs | W108-94 | 5-2 | .714 | TD Garden · Boston, MA |
| 8 | Wed Nov 1 | vs Kings | W113-86 | 6-2 | .750 | TD Garden · Boston, MA |
| 9 | Fri Nov 3 | at Thunder | W101-94 | 7-2 | .778 | Paycom Center · Oklahoma City, OK |
| 10 | Sun Nov 5 | at Magic | W104-88 | 8-2 | .800 | Amway Center · Orlando, FL |
| 11 | Mon Nov 6 | at Hawks | W110-107 | 9-2 | .818 | State Farm Arena · Atlanta, GA |
| 12 | Wed Nov 8 | vs Lakers | W107-96 | 10-2 | .833 | TD Garden · Boston, MA |
| 13 | Fri Nov 10 | vs Hornets | W90-87 | 11-2 | .846 | TD Garden · Boston, MA |
| 14 | Sun Nov 12 | vs Raptors | W95-94 | 12-2 | .857 | TD Garden · Boston, MA |
| 15 | Tue Nov 14 | at Nets | W109-102 | 13-2 | .867 | Barclays Center · Brooklyn, NY |
| 16 | Thu Nov 16 | vs Warriors | W92-88 | 14-2 | .875 | TD Garden · Boston, MA |
| 17 | Sat Nov 18 | atHawks | W110-99 | 15-2 | .882 | State Farm Arena · Atlanta, GA |
| 18 | Mon Nov 20 | at Mavericks | W110-102 (OT) | 16-2 | .889 | American Airlines Center · Dallas, TX |
| 19 | Wed Nov 22 | atHeat | L98-104 | 16-3 | .842 | FTX Arena · Miami, FL |
| 20 | Fri Nov 24 | vsMagic | W118-103 | 17-3 | .850 | TD Garden · Boston, MA |
| 21 | Sat Nov 25 | at Pacers | W108-98 | 18-3 | .857 | Gainbridge Fieldhouse · Indianapolis, IN |
| 22 | Mon Nov 27 | vs Pistons | L108-118 | 18-4 | .818 | TD Garden · Boston, MA |
| 23 | Thu Nov 30 | vs76ers | W108-97 | 19-4 | .826 | TD Garden · Boston, MA |
| 24 | Sat Dec 2 | vs Suns | W116-111 | 20-4 | .833 | TD Garden · Boston, MA |
| 25 | Mon Dec 4 | vsBucks | W111-100 | 21-4 | .840 | TD Garden · Boston, MA |
| 26 | Wed Dec 6 | vsMavericks | W97-90 | 22-4 | .846 | TD Garden · Boston, MA |
| 27 | Fri Dec 8 | atSpurs | L102-105 | 22-5 | .815 | AT&T Center · San Antonio, TX |
| 28 | Sun Dec 10 | atPistons | W91-81 | 23-5 | .821 | Little Caesars Arena · Detroit, MI |
| 29 | Mon Dec 11 | at Bulls | L85-108 | 23-6 | .793 | United Center · Chicago, IL |
| 30 | Wed Dec 13 | vs Nuggets | W124-118 | 24-6 | .800 | TD Garden · Boston, MA |
| 31 | Fri Dec 15 | vs Jazz | L95-107 | 24-7 | .774 | TD Garden · Boston, MA |
| 32 | Sat Dec 16 | at Grizzlies | W102-93 | 25-7 | .781 | FedExForum · Memphis, TN |
| 33 | Mon Dec 18 | atPacers | W112-111 | 26-7 | .788 | Gainbridge Fieldhouse · Indianapolis, IN |
| 34 | Wed Dec 20 | vsHeat | L89-90 | 26-8 | .765 | TD Garden · Boston, MA |
| 35 | Thu Dec 21 | atKnicks | L93-102 | 26-9 | .743 | Madison Square Garden · Manhattan, NY |
| 36 | Sat Dec 23 | vsBulls | W117-92 | 27-9 | .750 | TD Garden · Boston, MA |
| 37 | Mon Dec 25 | vs Wizards | L103-111 | 27-10 | .730 | TD Garden · Boston, MA |
| 38 | Wed Dec 27 | atHornets | W102-91 | 28-10 | .737 | Spectrum Center · Charlotte, NC |
| 39 | Thu Dec 28 | vs Rockets | W99-98 | 29-10 | .744 | TD Garden · Boston, MA |
| 40 | Sun Dec 31 | vsNets | W108-105 | 30-10 | .750 | TD Garden · Boston, MA |
| 41 | Wed Jan 3 | vsCavaliers | W102-88 | 31-10 | .756 | TD Garden · Boston, MA |
| 42 | Fri Jan 5 | vs T-wolves | W91-84 | 32-10 | .762 | TD Garden · Boston, MA |
| 43 | Sat Jan 6 | atNets | W87-85 | 33-10 | .767 | Barclays Center · Brooklyn, NY |
| 44 | Thu Jan 11 | at76ers | W114-103 | 34-10 | .773 | Wells Fargo Center · Philadelphia, PA |
| 45 | Tue Jan 16 | vs Pelicans | L113-116 (OT) | 34-11 | .756 | TD Garden · Boston, MA |
| 46 | Thu Jan 18 | vs76ers | L80-89 | 34-12 | .739 | TD Garden · Boston, MA |
| 47 | Sun Jan 21 | vsMagic | L95-103 | 34-13 | .723 | TD Garden · Boston, MA |
| 48 | Tue Jan 23 | atLakers | L107-108 | 34-14 | .708 | Crypto.com Arena · Los Angeles, CA |
| 49 | Wed Jan 24 | at Clippers | W113-102 | 35-14 | .714 | Crypto.com Arena · Los Angeles, CA |
| 50 | Sat Jan 27 | atWarriors | L105-109 | 35-15 | .700 | Chase Center · San Francisco, CA |
| 51 | Mon Jan 29 | atNuggets | W111-110 | 36-15 | .706 | Ball Arena · Denver, CO |
| 52 | Wed Jan 31 | vsKnicks | W103-73 | 37-15 | .712 | TD Garden · Boston, MA |
| 53 | Fri Feb 2 | vsHawks | W119-110 | 38-15 | .717 | TD Garden · Boston, MA |
| 54 | Sun Feb 4 | vs Blazers | W97-96 | 39-15 | .722 | TD Garden · Boston, MA |
| 55 | Tue Feb 6 | atRaptors | L91-111 | 39-16 | .709 | Scotiabank Arena · Toronto, ON |
| 56 | Thu Feb 8 | atWizards | W110-104 (OT) | 40-16 | .714 | Capital One Arena · Washington, D.C. |
| 57 | Fri Feb 9 | vsPacers | L91-97 | 40-17 | .702 | TD Garden · Boston, MA |
| 58 | Sun Feb 11 | vsCavaliers | L99-121 | 40-18 | .690 | TD Garden · Boston, MA |
| 59 | Wed Feb 14 | vsClippers | L119-129 | 40-19 | .678 | TD Garden · Boston, MA |
| 60 | Fri Feb 23 | atPistons | W110-98 | 41-19 | .683 | Little Caesars Arena · Detroit, MI |
| 61 | Sat Feb 24 | atKnicks | W121-112 | 42-19 | .689 | Madison Square Garden · Manhattan, NY |
| 62 | Mon Feb 26 | vsGrizzlies | W109-98 | 43-19 | .694 | TD Garden · Boston, MA |
| 63 | Wed Feb 28 | vsHornets | W134-106 | 44-19 | .698 | TD Garden · Boston, MA |
| 64 | Sat Mar 3 | atRockets | L120-123 | 44-20 | .688 | Toyota Center · Houston, TX |
| 65 | Mon Mar 5 | atBulls | W105-89 | 45-20 | .692 | United Center · Chicago, IL |
| 66 | Thu Mar 8 | atT-wolves | W117-109 | 46-20 | .697 | Target Center · Minneapolis, MN |
| 67 | Sun Mar 11 | vsPacers | L97-99 | 46-21 | .687 | TD Garden · Boston, MA |
| 68 | Wed Mar 14 | vsWizards | L124-125 (2OT) | 46-22 | .676 | TD Garden · Boston, MA |
| 69 | Fri Mar 16 | atMagic | W92-83 | 47-22 | .681 | Amway Center · Orlando, FL |
| 70 | Sun Mar 18 | atPelicans | L89-108 | 47-23 | .671 | Smoothie King Center · New Orleans, LA |
| 71 | Tue Mar 20 | vsThunder | W100-99 | 48-23 | .676 | TD Garden · Boston, MA |
| 72 | Fri Mar 23 | atBlazers | W105-100 | 49-23 | .681 | Moda Center · Portland, OR |
| 73 | Sun Mar 25 | atKings | W104-93 | 50-23 | .685 | Golden 1 Center · Sacramento, CA |
| 74 | Mon Mar 26 | atSuns | W102-94 | 51-23 | .689 | Footprint Center · Phoenix, AZ |
| 75 | Wed Mar 28 | atJazz | W97-94 | 52-23 | .693 | Vivint Arena · Salt Lake City, UT |
| 76 | Sat Mar 31 | vsRaptors | W110-99 | 53-23 | .697 | TD Garden · Boston, MA |
| 77 | Tue Apr 3 | atBucks | L102-106 | 53-24 | .688 | Fiserv Forum · Milwaukee, WI |
| 78 | Wed Apr 4 | atRaptors | L78-96 | 53-25 | .679 | Scotiabank Arena · Toronto, ON |
| 79 | Fri Apr 6 | vsBulls | W111-104 | 54-25 | .684 | TD Garden · Boston, MA |
| 80 | Sun Apr 8 | vsHawks | L106-112 | 54-26 | .675 | TD Garden · Boston, MA |
| 81 | Tue Apr 10 | atWizards | L101-113 | 54-27 | .667 | Capital One Arena · Washington, D.C. |
| 82 | Wed Apr 11 | vsNets | W110-97 | 55-27 | .671 | TD Garden · Boston, MA |
| 1 | Sun Apr 15 | vsBucks | W113-107 (OT) | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Tue Apr 17 | vsBucks | W120-106 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Fri Apr 20 | atBucks | L92-116 | 2-1 | .667 | Fiserv Forum · Milwaukee, WI |
| 4 | Sun Apr 22 | atBucks | L102-104 | 2-2 | .500 | Fiserv Forum · Milwaukee, WI |
| 5 | Tue Apr 24 | vsBucks | W92-87 | 3-2 | .600 | TD Garden · Boston, MA |
| 6 | Thu Apr 26 | atBucks | L86-97 | 3-3 | .500 | Fiserv Forum · Milwaukee, WI |
| 7 | Sat Apr 28 | vsBucks | W112-96 | 4-3 | .571 | TD Garden · Boston, MA |
| 1 | Mon Apr 30 | vs76ers | W117-101 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Thu May 3 | vs76ers | W108-103 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Sat May 5 | at76ers | W101-98 (OT) | 3-0 | 1.000 | Wells Fargo Center · Philadelphia, PA |
| 4 | Mon May 7 | at76ers | L92-103 | 3-1 | .750 | Wells Fargo Center · Philadelphia, PA |
| 5 | Wed May 9 | vs76ers | W114-112 | 4-1 | .800 | TD Garden · Boston, MA |
| 1 | Sun May 13 | vsCavaliers | W108-83 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Tue May 15 | vsCavaliers | W107-94 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Sat May 19 | atCavaliers | L86-116 | 2-1 | .667 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 4 | Mon May 21 | atCavaliers | L102-111 | 2-2 | .500 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 5 | Wed May 23 | vsCavaliers | W96-83 | 3-2 | .600 | TD Garden · Boston, MA |
| 6 | Fri May 25 | atCavaliers | L99-109 | 3-3 | .500 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 7 | Sun May 27 | vsCavaliers | L79-87 | 3-4 | .429 | TD Garden · Boston, MA |
