| 1 | Wed Oct 20 | at Knicks | L134-138 (2OT) | 0-1 | .000 | Madison Square Garden · Manhattan, NY |
| 2 | Fri Oct 22 | vs Raptors | L83-115 | 0-2 | .000 | TD Garden · Boston, MA |
| 3 | Sun Oct 24 | at Rockets | W107-97 | 1-2 | .333 | Toyota Center · Houston, TX |
| 4 | Mon Oct 25 | at Hornets | W140-129 (OT) | 2-2 | .500 | Spectrum Center · Charlotte, NC |
| 5 | Wed Oct 27 | vs Wizards | L107-116 | 2-3 | .400 | TD Garden · Boston, MA |
| 6 | Sat Oct 30 | atWizards | L112-115 (2OT) | 2-4 | .333 | Capital One Arena · Washington, D.C. |
| 7 | Mon Nov 1 | vs Bulls | L114-128 | 2-5 | .286 | TD Garden · Boston, MA |
| 8 | Wed Nov 3 | at Magic | W92-79 | 3-5 | .375 | Amway Center · Orlando, FL |
| 9 | Thu Nov 4 | at Heat | W95-78 | 4-5 | .444 | FTX Arena · Miami, FL |
| 10 | Sat Nov 6 | at Mavericks | L104-107 | 4-6 | .400 | American Airlines Center · Dallas, TX |
| 11 | Wed Nov 10 | vsRaptors | W104-88 | 5-6 | .455 | TD Garden · Boston, MA |
| 12 | Fri Nov 12 | vs Bucks | W122-113 (OT) | 6-6 | .500 | TD Garden · Boston, MA |
| 13 | Sat Nov 13 | at Cavaliers | L89-91 | 6-7 | .462 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 14 | Mon Nov 15 | atCavaliers | W98-92 | 7-7 | .500 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 15 | Wed Nov 17 | at Hawks | L99-110 | 7-8 | .467 | State Farm Arena · Atlanta, GA |
| 16 | Fri Nov 19 | vs Lakers | W130-108 | 8-8 | .500 | TD Garden · Boston, MA |
| 17 | Sat Nov 20 | vs Thunder | W111-105 | 9-8 | .529 | TD Garden · Boston, MA |
| 18 | Mon Nov 22 | vsRockets | W108-90 | 10-8 | .556 | TD Garden · Boston, MA |
| 19 | Wed Nov 24 | vs Nets | L104-123 | 10-9 | .526 | TD Garden · Boston, MA |
| 20 | Fri Nov 26 | at Spurs | L88-96 | 10-10 | .500 | AT&T Center · San Antonio, TX |
| 21 | Sun Nov 28 | atRaptors | W109-97 | 11-10 | .524 | Scotiabank Arena · Toronto, ON |
| 22 | Wed Dec 1 | vs 76ers | W88-87 | 12-10 | .545 | TD Garden · Boston, MA |
| 23 | Fri Dec 3 | at Jazz | L130-137 | 12-11 | .522 | Vivint Arena · Salt Lake City, UT |
| 24 | Sat Dec 4 | at Blazers | W145-117 | 13-11 | .542 | Moda Center · Portland, OR |
| 25 | Tue Dec 7 | atLakers | L102-117 | 13-12 | .520 | Crypto.com Arena · Los Angeles, CA |
| 26 | Wed Dec 8 | at Clippers | L111-114 | 13-13 | .500 | Crypto.com Arena · Los Angeles, CA |
| 27 | Fri Dec 10 | at Suns | L90-111 | 13-14 | .481 | Footprint Center · Phoenix, AZ |
| 28 | Mon Dec 13 | vsBucks | W117-103 | 14-14 | .500 | TD Garden · Boston, MA |
| 29 | Fri Dec 17 | vs Warriors | L107-111 | 14-15 | .483 | TD Garden · Boston, MA |
| 30 | Sat Dec 18 | vsKnicks | W114-107 | 15-15 | .500 | TD Garden · Boston, MA |
| 31 | Mon Dec 20 | vs76ers | L103-108 | 15-16 | .484 | TD Garden · Boston, MA |
| 32 | Wed Dec 22 | vsCavaliers | W111-101 | 16-16 | .500 | TD Garden · Boston, MA |
| 33 | Sat Dec 25 | atBucks | L113-117 | 16-17 | .485 | Fiserv Forum · Milwaukee, WI |
| 34 | Mon Dec 27 | at T-wolves | L103-108 | 16-18 | .471 | Target Center · Minneapolis, MN |
| 35 | Wed Dec 29 | vsClippers | L82-91 | 16-19 | .457 | TD Garden · Boston, MA |
| 36 | Fri Dec 31 | vsSuns | W123-108 | 17-19 | .472 | TD Garden · Boston, MA |
| 37 | Sun Jan 2 | vsMagic | W116-111 (OT) | 18-19 | .486 | TD Garden · Boston, MA |
| 38 | Wed Jan 5 | vsSpurs | L97-99 | 18-20 | .474 | TD Garden · Boston, MA |
| 39 | Thu Jan 6 | atKnicks | L105-108 | 18-21 | .462 | Madison Square Garden · Manhattan, NY |
| 40 | Sat Jan 8 | vsKnicks | W99-75 | 19-21 | .475 | TD Garden · Boston, MA |
| 41 | Mon Jan 10 | vs Pacers | W101-98 (OT) | 20-21 | .488 | TD Garden · Boston, MA |
| 42 | Wed Jan 12 | atPacers | W119-100 | 21-21 | .500 | Gainbridge Fieldhouse · Indianapolis, IN |
| 43 | Fri Jan 14 | at76ers | L99-111 | 21-22 | .488 | Wells Fargo Center · Philadelphia, PA |
| 44 | Sat Jan 15 | vsBulls | W114-112 | 22-22 | .500 | TD Garden · Boston, MA |
| 45 | Mon Jan 17 | vs Pelicans | W104-92 | 23-22 | .511 | TD Garden · Boston, MA |
| 46 | Wed Jan 19 | vsHornets | L102-111 | 23-23 | .500 | TD Garden · Boston, MA |
| 47 | Fri Jan 21 | vsBlazers | L105-109 | 23-24 | .489 | TD Garden · Boston, MA |
| 48 | Sun Jan 23 | atWizards | W116-87 | 24-24 | .500 | Capital One Arena · Washington, D.C. |
| 49 | Tue Jan 25 | vs Kings | W128-75 | 25-24 | .510 | TD Garden · Boston, MA |
| 50 | Fri Jan 28 | atHawks | L92-108 | 25-25 | .500 | State Farm Arena · Atlanta, GA |
| 51 | Sat Jan 29 | atPelicans | W107-97 | 26-25 | .510 | Smoothie King Center · New Orleans, LA |
| 52 | Mon Jan 31 | vsHeat | W122-92 | 27-25 | .519 | TD Garden · Boston, MA |
| 53 | Wed Feb 2 | vsHornets | W113-107 | 28-25 | .528 | TD Garden · Boston, MA |
| 54 | Fri Feb 4 | at Pistons | W102-93 | 29-25 | .537 | Little Caesars Arena · Detroit, MI |
| 55 | Sun Feb 6 | atMagic | W116-83 | 30-25 | .545 | Amway Center · Orlando, FL |
| 56 | Tue Feb 8 | atNets | W126-91 | 31-25 | .554 | Barclays Center · Brooklyn, NY |
| 57 | Fri Feb 11 | vs Nuggets | W108-102 | 32-25 | .561 | TD Garden · Boston, MA |
| 58 | Sun Feb 13 | vsHawks | W105-95 | 33-25 | .569 | TD Garden · Boston, MA |
| 59 | Tue Feb 15 | at76ers | W135-87 | 34-25 | .576 | Wells Fargo Center · Philadelphia, PA |
| 60 | Wed Feb 16 | vsPistons | L111-112 | 34-26 | .567 | TD Garden · Boston, MA |
| 61 | Thu Feb 24 | atNets | W129-106 | 35-26 | .574 | Barclays Center · Brooklyn, NY |
| 62 | Sat Feb 26 | atPistons | W113-104 | 36-26 | .581 | Little Caesars Arena · Detroit, MI |
| 63 | Sun Feb 27 | atPacers | L107-128 | 36-27 | .571 | Gainbridge Fieldhouse · Indianapolis, IN |
| 64 | Tue Mar 1 | vsHawks | W107-98 | 37-27 | .578 | TD Garden · Boston, MA |
| 65 | Thu Mar 3 | vs Grizzlies | W120-107 | 38-27 | .585 | TD Garden · Boston, MA |
| 66 | Sun Mar 6 | vsNets | W126-120 | 39-27 | .591 | TD Garden · Boston, MA |
| 67 | Wed Mar 9 | atHornets | W115-101 | 40-27 | .597 | Spectrum Center · Charlotte, NC |
| 68 | Fri Mar 11 | vsPistons | W114-103 | 41-27 | .603 | TD Garden · Boston, MA |
| 69 | Sun Mar 13 | vsMavericks | L92-95 | 41-28 | .594 | TD Garden · Boston, MA |
| 70 | Wed Mar 16 | atWarriors | W110-88 | 42-28 | .600 | Chase Center · San Francisco, CA |
| 71 | Fri Mar 18 | atKings | W126-97 | 43-28 | .606 | Golden 1 Center · Sacramento, CA |
| 72 | Sun Mar 20 | atNuggets | W124-104 | 44-28 | .611 | Ball Arena · Denver, CO |
| 73 | Mon Mar 21 | atThunder | W132-123 | 45-28 | .616 | Paycom Center · Oklahoma City, OK |
| 74 | Wed Mar 23 | vsJazz | W125-97 | 46-28 | .622 | TD Garden · Boston, MA |
| 75 | Sun Mar 27 | vsT-wolves | W134-112 | 47-28 | .627 | TD Garden · Boston, MA |
| 76 | Mon Mar 28 | atRaptors | L112-115 (OT) | 47-29 | .618 | Scotiabank Arena · Toronto, ON |
| 77 | Wed Mar 30 | vsHeat | L98-106 | 47-30 | .610 | TD Garden · Boston, MA |
| 78 | Fri Apr 1 | vsPacers | W128-123 | 48-30 | .615 | TD Garden · Boston, MA |
| 79 | Sun Apr 3 | vsWizards | W144-102 | 49-30 | .620 | TD Garden · Boston, MA |
| 80 | Wed Apr 6 | atBulls | W117-94 | 50-30 | .625 | United Center · Chicago, IL |
| 81 | Thu Apr 7 | atBucks | L121-127 | 50-31 | .617 | Fiserv Forum · Milwaukee, WI |
| 82 | Sun Apr 10 | atGrizzlies | W139-110 | 51-31 | .622 | FedExForum · Memphis, TN |
| 1 | Sun Apr 17 | vsNets | W115-114 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Wed Apr 20 | vsNets | W114-107 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Sat Apr 23 | atNets | W109-103 | 3-0 | 1.000 | Barclays Center · Brooklyn, NY |
| 4 | Mon Apr 25 | atNets | W116-112 | 4-0 | 1.000 | Barclays Center · Brooklyn, NY |
| 1 | Sun May 1 | vsBucks | L89-101 | 0-1 | .000 | TD Garden · Boston, MA |
| 2 | Tue May 3 | vsBucks | W109-86 | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Sat May 7 | atBucks | L101-103 | 1-2 | .333 | Fiserv Forum · Milwaukee, WI |
| 4 | Mon May 9 | atBucks | W116-108 | 2-2 | .500 | Fiserv Forum · Milwaukee, WI |
| 5 | Wed May 11 | vsBucks | L107-110 | 2-3 | .400 | TD Garden · Boston, MA |
| 6 | Fri May 13 | atBucks | W108-95 | 3-3 | .500 | Fiserv Forum · Milwaukee, WI |
| 7 | Sun May 15 | vsBucks | W109-81 | 4-3 | .571 | TD Garden · Boston, MA |
| 1 | Tue May 17 | atHeat | L107-118 | 0-1 | .000 | FTX Arena · Miami, FL |
| 2 | Thu May 19 | atHeat | W127-102 | 1-1 | .500 | FTX Arena · Miami, FL |
| 3 | Sat May 21 | vsHeat | L103-109 | 1-2 | .333 | TD Garden · Boston, MA |
| 4 | Mon May 23 | vsHeat | W102-82 | 2-2 | .500 | TD Garden · Boston, MA |
| 5 | Wed May 25 | atHeat | W93-80 | 3-2 | .600 | FTX Arena · Miami, FL |
| 6 | Fri May 27 | vsHeat | L103-111 | 3-3 | .500 | TD Garden · Boston, MA |
| 7 | Sun May 29 | atHeat | W100-96 | 4-3 | .571 | FTX Arena · Miami, FL |
| 1 | Thu Jun 2 | atWarriors | W120-108 | 1-0 | 1.000 | Chase Center · San Francisco, CA |
| 2 | Sun Jun 5 | atWarriors | L88-107 | 1-1 | .500 | Chase Center · San Francisco, CA |
| 3 | Wed Jun 8 | vsWarriors | W116-100 | 2-1 | .667 | TD Garden · Boston, MA |
| 4 | Fri Jun 10 | vsWarriors | L97-107 | 2-2 | .500 | TD Garden · Boston, MA |
| 5 | Mon Jun 13 | atWarriors | L94-104 | 2-3 | .400 | Chase Center · San Francisco, CA |
| 6 | Thu Jun 16 | vsWarriors | L90-103 | 2-4 | .333 | TD Garden · Boston, MA |
