| 1 | Tue Oct 18 | vs 76ers | W126-117 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Fri Oct 21 | at Heat | W111-104 | 2-0 | 1.000 | FTX Arena · Miami, FL |
| 3 | Sat Oct 22 | at Magic | W126-120 | 3-0 | 1.000 | Amway Center · Orlando, FL |
| 4 | Mon Oct 24 | at Bulls | L102-120 | 3-1 | .750 | United Center · Chicago, IL |
| 5 | Fri Oct 28 | vs Cavaliers | L123-132 (OT) | 3-2 | .600 | TD Garden · Boston, MA |
| 6 | Sun Oct 30 | vs Wizards | W112-94 | 4-2 | .667 | TD Garden · Boston, MA |
| 7 | Wed Nov 2 | atCavaliers | L113-114 (OT) | 4-3 | .571 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 8 | Fri Nov 4 | vsBulls | W123-119 | 5-3 | .625 | TD Garden · Boston, MA |
| 9 | Sat Nov 5 | at Knicks | W133-118 | 6-3 | .667 | Madison Square Garden · Manhattan, NY |
| 10 | Mon Nov 7 | at Grizzlies | W109-106 | 7-3 | .700 | FedExForum · Memphis, TN |
| 11 | Wed Nov 9 | vs Pistons | W128-112 | 8-3 | .727 | TD Garden · Boston, MA |
| 12 | Fri Nov 11 | vs Nuggets | W131-112 | 9-3 | .750 | TD Garden · Boston, MA |
| 13 | Sat Nov 12 | atPistons | W117-108 | 10-3 | .769 | Little Caesars Arena · Detroit, MI |
| 14 | Mon Nov 14 | vs Thunder | W126-122 | 11-3 | .786 | TD Garden · Boston, MA |
| 15 | Wed Nov 16 | at Hawks | W126-101 | 12-3 | .800 | State Farm Arena · Atlanta, GA |
| 16 | Fri Nov 18 | at Pelicans | W117-109 | 13-3 | .813 | Smoothie King Center · New Orleans, LA |
| 17 | Mon Nov 21 | atBulls | L107-121 | 13-4 | .765 | United Center · Chicago, IL |
| 18 | Wed Nov 23 | vs Mavericks | W125-112 | 14-4 | .778 | TD Garden · Boston, MA |
| 19 | Fri Nov 25 | vs Kings | W122-104 | 15-4 | .789 | TD Garden · Boston, MA |
| 20 | Sun Nov 27 | vsWizards | W130-121 | 16-4 | .800 | TD Garden · Boston, MA |
| 21 | Mon Nov 28 | vs Hornets | W140-105 | 17-4 | .810 | TD Garden · Boston, MA |
| 22 | Wed Nov 30 | vsHeat | W134-121 | 18-4 | .818 | TD Garden · Boston, MA |
| 23 | Fri Dec 2 | vsHeat | L116-120 (OT) | 18-5 | .783 | TD Garden · Boston, MA |
| 24 | Sun Dec 4 | at Nets | W103-92 | 19-5 | .792 | Barclays Center · Brooklyn, NY |
| 25 | Mon Dec 5 | at Raptors | W116-110 | 20-5 | .800 | Scotiabank Arena · Toronto, ON |
| 26 | Wed Dec 7 | at Suns | W125-98 | 21-5 | .808 | Footprint Center · Phoenix, AZ |
| 27 | Sat Dec 10 | at Warriors | L107-123 | 21-6 | .778 | Chase Center · San Francisco, CA |
| 28 | Mon Dec 12 | at Clippers | L93-113 | 21-7 | .750 | Crypto.com Arena · Los Angeles, CA |
| 29 | Tue Dec 13 | at Lakers | W122-118 (OT) | 22-7 | .759 | Crypto.com Arena · Los Angeles, CA |
| 30 | Fri Dec 16 | vsMagic | L109-117 | 22-8 | .733 | TD Garden · Boston, MA |
| 31 | Sun Dec 18 | vsMagic | L92-95 | 22-9 | .710 | TD Garden · Boston, MA |
| 32 | Wed Dec 21 | vs Pacers | L112-117 | 22-10 | .688 | TD Garden · Boston, MA |
| 33 | Fri Dec 23 | vs T-wolves | W121-109 | 23-10 | .697 | TD Garden · Boston, MA |
| 34 | Sun Dec 25 | vs Bucks | W139-118 | 24-10 | .706 | TD Garden · Boston, MA |
| 35 | Tue Dec 27 | vs Rockets | W126-102 | 25-10 | .714 | TD Garden · Boston, MA |
| 36 | Thu Dec 29 | vsClippers | W116-110 | 26-10 | .722 | TD Garden · Boston, MA |
| 37 | Sun Jan 1 | atNuggets | L111-123 | 26-11 | .703 | Ball Arena · Denver, CO |
| 38 | Tue Jan 3 | atThunder | L117-150 | 26-12 | .684 | Paycom Center · Oklahoma City, OK |
| 39 | Thu Jan 5 | atMavericks | W124-95 | 27-12 | .692 | American Airlines Center · Dallas, TX |
| 40 | Sat Jan 7 | at Spurs | W121-116 | 28-12 | .700 | AT&T Center · San Antonio, TX |
| 41 | Mon Jan 9 | vsBulls | W107-99 | 29-12 | .707 | TD Garden · Boston, MA |
| 42 | Wed Jan 11 | vsPelicans | W125-114 | 30-12 | .714 | TD Garden · Boston, MA |
| 43 | Thu Jan 12 | atNets | W109-98 | 31-12 | .721 | Barclays Center · Brooklyn, NY |
| 44 | Sat Jan 14 | atHornets | W122-106 | 32-12 | .727 | Spectrum Center · Charlotte, NC |
| 45 | Mon Jan 16 | atHornets | W130-118 | 33-12 | .733 | Spectrum Center · Charlotte, NC |
| 46 | Thu Jan 19 | vsWarriors | W121-118 (OT) | 34-12 | .739 | TD Garden · Boston, MA |
| 47 | Sat Jan 21 | atRaptors | W106-104 | 35-12 | .745 | Scotiabank Arena · Toronto, ON |
| 48 | Mon Jan 23 | atMagic | L98-113 | 35-13 | .729 | Amway Center · Orlando, FL |
| 49 | Tue Jan 24 | atHeat | L95-98 | 35-14 | .714 | FTX Arena · Miami, FL |
| 50 | Thu Jan 26 | vsKnicks | L117-120 (OT) | 35-15 | .700 | TD Garden · Boston, MA |
| 51 | Sat Jan 28 | vsLakers | W125-121 (OT) | 36-15 | .706 | TD Garden · Boston, MA |
| 52 | Wed Feb 1 | vsNets | W139-96 | 37-15 | .712 | TD Garden · Boston, MA |
| 53 | Fri Feb 3 | vsSuns | L94-106 | 37-16 | .698 | TD Garden · Boston, MA |
| 54 | Mon Feb 6 | atPistons | W111-99 | 38-16 | .704 | Little Caesars Arena · Detroit, MI |
| 55 | Wed Feb 8 | vs76ers | W106-99 | 39-16 | .709 | TD Garden · Boston, MA |
| 56 | Fri Feb 10 | vsHornets | W127-116 | 40-16 | .714 | TD Garden · Boston, MA |
| 57 | Sun Feb 12 | vsGrizzlies | W119-109 | 41-16 | .719 | TD Garden · Boston, MA |
| 58 | Tue Feb 14 | atBucks | L125-131 (OT) | 41-17 | .707 | Fiserv Forum · Milwaukee, WI |
| 59 | Wed Feb 15 | vsPistons | W127-109 | 42-17 | .712 | TD Garden · Boston, MA |
| 60 | Thu Feb 23 | atPacers | W142-138 (OT) | 43-17 | .717 | Gainbridge Fieldhouse · Indianapolis, IN |
| 61 | Sat Feb 25 | at76ers | W110-107 | 44-17 | .721 | Wells Fargo Center · Philadelphia, PA |
| 62 | Mon Feb 27 | atKnicks | L94-109 | 44-18 | .710 | Madison Square Garden · Manhattan, NY |
| 63 | Wed Mar 1 | vsCavaliers | W117-113 | 45-18 | .714 | TD Garden · Boston, MA |
| 64 | Fri Mar 3 | vsNets | L105-115 | 45-19 | .703 | TD Garden · Boston, MA |
| 65 | Sun Mar 5 | vsKnicks | L129-131 (2OT) | 45-20 | .692 | TD Garden · Boston, MA |
| 66 | Mon Mar 6 | atCavaliers | L114-118 (OT) | 45-21 | .682 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 67 | Wed Mar 8 | vs Blazers | W115-93 | 46-21 | .687 | TD Garden · Boston, MA |
| 68 | Sat Mar 11 | atHawks | W134-125 | 47-21 | .691 | State Farm Arena · Atlanta, GA |
| 69 | Mon Mar 13 | atRockets | L109-111 | 47-22 | .681 | Toyota Center · Houston, TX |
| 70 | Wed Mar 15 | atT-wolves | W104-102 | 48-22 | .686 | Target Center · Minneapolis, MN |
| 71 | Fri Mar 17 | atBlazers | W126-112 | 49-22 | .690 | Moda Center · Portland, OR |
| 72 | Sat Mar 18 | at Jazz | L117-118 | 49-23 | .681 | Vivint Arena · Salt Lake City, UT |
| 73 | Tue Mar 21 | atKings | W132-109 | 50-23 | .685 | Golden 1 Center · Sacramento, CA |
| 74 | Fri Mar 24 | vsPacers | W120-95 | 51-23 | .689 | TD Garden · Boston, MA |
| 75 | Sun Mar 26 | vsSpurs | W137-93 | 52-23 | .693 | TD Garden · Boston, MA |
| 76 | Tue Mar 28 | atWizards | L111-130 | 52-24 | .684 | Capital One Arena · Washington, D.C. |
| 77 | Thu Mar 30 | atBucks | W140-99 | 53-24 | .688 | Fiserv Forum · Milwaukee, WI |
| 78 | Fri Mar 31 | vsJazz | W122-114 | 54-24 | .692 | TD Garden · Boston, MA |
| 79 | Tue Apr 4 | at76ers | L101-103 | 54-25 | .684 | Wells Fargo Center · Philadelphia, PA |
| 80 | Wed Apr 5 | vsRaptors | W97-93 | 55-25 | .688 | TD Garden · Boston, MA |
| 81 | Fri Apr 7 | vsRaptors | W121-102 | 56-25 | .691 | TD Garden · Boston, MA |
| 82 | Sun Apr 9 | vsHawks | W120-114 | 57-25 | .695 | TD Garden · Boston, MA |
| 1 | Sat Apr 15 | vsHawks | W112-99 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Tue Apr 18 | vsHawks | W119-106 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Fri Apr 21 | atHawks | L122-130 | 2-1 | .667 | State Farm Arena · Atlanta, GA |
| 4 | Sun Apr 23 | atHawks | W129-121 | 3-1 | .750 | State Farm Arena · Atlanta, GA |
| 5 | Tue Apr 25 | vsHawks | L117-119 | 3-2 | .600 | TD Garden · Boston, MA |
| 6 | Thu Apr 27 | atHawks | W128-120 | 4-2 | .667 | State Farm Arena · Atlanta, GA |
| 1 | Mon May 1 | vs76ers | L115-119 | 0-1 | .000 | TD Garden · Boston, MA |
| 2 | Wed May 3 | vs76ers | W121-87 | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Fri May 5 | at76ers | W114-102 | 2-1 | .667 | Wells Fargo Center · Philadelphia, PA |
| 4 | Sun May 7 | at76ers | L115-116 (OT) | 2-2 | .500 | Wells Fargo Center · Philadelphia, PA |
| 5 | Tue May 9 | vs76ers | L103-115 | 2-3 | .400 | TD Garden · Boston, MA |
| 6 | Thu May 11 | at76ers | W95-86 | 3-3 | .500 | Wells Fargo Center · Philadelphia, PA |
| 7 | Sun May 14 | vs76ers | W112-88 | 4-3 | .571 | TD Garden · Boston, MA |
| 1 | Wed May 17 | vsHeat | L116-123 | 0-1 | .000 | TD Garden · Boston, MA |
| 2 | Fri May 19 | vsHeat | L105-111 | 0-2 | .000 | TD Garden · Boston, MA |
| 3 | Sun May 21 | atHeat | L102-128 | 0-3 | .000 | FTX Arena · Miami, FL |
| 4 | Tue May 23 | atHeat | W116-99 | 1-3 | .250 | FTX Arena · Miami, FL |
| 5 | Thu May 25 | vsHeat | W110-97 | 2-3 | .400 | TD Garden · Boston, MA |
| 6 | Sat May 27 | atHeat | W104-103 | 3-3 | .500 | FTX Arena · Miami, FL |
| 7 | Mon May 29 | vsHeat | L84-103 | 3-4 | .429 | TD Garden · Boston, MA |
