| 1 | Wed Oct 23 | at 76ers | L93-107 | 0-1 | .000 | Wells Fargo Center · Philadelphia, PA |
| 2 | Fri Oct 25 | vs Raptors | W112-106 | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Sat Oct 26 | at Knicks | W118-95 | 2-1 | .667 | Madison Square Garden · Manhattan, NY |
| 4 | Wed Oct 30 | vs Bucks | W116-105 | 3-1 | .750 | TD Garden · Boston, MA |
| 5 | Fri Nov 1 | vsKnicks | W104-102 | 4-1 | .800 | TD Garden · Boston, MA |
| 6 | Tue Nov 5 | at Cavaliers | W119-113 | 5-1 | .833 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 7 | Thu Nov 7 | at Hornets | W108-87 | 6-1 | .857 | Spectrum Center · Charlotte, NC |
| 8 | Sat Nov 9 | at Spurs | W135-115 | 7-1 | .875 | AT&T Center · San Antonio, TX |
| 9 | Mon Nov 11 | vs Mavericks | W116-106 | 8-1 | .889 | TD Garden · Boston, MA |
| 10 | Wed Nov 13 | vs Wizards | W140-133 | 9-1 | .900 | TD Garden · Boston, MA |
| 11 | Fri Nov 15 | at Warriors | W105-100 | 10-1 | .909 | Chase Center · San Francisco, CA |
| 12 | Sun Nov 17 | at Kings | L99-100 | 10-2 | .833 | Golden 1 Center · Sacramento, CA |
| 13 | Mon Nov 18 | at Suns | W99-85 | 11-2 | .846 | Footprint Center · Phoenix, AZ |
| 14 | Wed Nov 20 | at Clippers | L104-107 (OT) | 11-3 | .786 | Crypto.com Arena · Los Angeles, CA |
| 15 | Fri Nov 22 | at Nuggets | L92-96 | 11-4 | .733 | Ball Arena · Denver, CO |
| 16 | Mon Nov 25 | vsKings | W103-102 | 12-4 | .750 | TD Garden · Boston, MA |
| 17 | Wed Nov 27 | vs Nets | W121-110 | 13-4 | .765 | TD Garden · Boston, MA |
| 18 | Fri Nov 29 | atNets | L107-112 | 13-5 | .722 | Barclays Center · Brooklyn, NY |
| 19 | Sun Dec 1 | atKnicks | W113-104 | 14-5 | .737 | Madison Square Garden · Manhattan, NY |
| 20 | Wed Dec 4 | vs Heat | W112-93 | 15-5 | .750 | TD Garden · Boston, MA |
| 21 | Fri Dec 6 | vsNuggets | W108-95 | 16-5 | .762 | TD Garden · Boston, MA |
| 22 | Mon Dec 9 | vsCavaliers | W110-88 | 17-5 | .773 | TD Garden · Boston, MA |
| 23 | Wed Dec 11 | at Pacers | L117-122 | 17-6 | .739 | Gainbridge Fieldhouse · Indianapolis, IN |
| 24 | Thu Dec 12 | vs76ers | L109-115 | 17-7 | .708 | TD Garden · Boston, MA |
| 25 | Wed Dec 18 | atMavericks | W109-103 | 18-7 | .720 | American Airlines Center · Dallas, TX |
| 26 | Fri Dec 20 | vs Pistons | W114-93 | 19-7 | .731 | TD Garden · Boston, MA |
| 27 | Sun Dec 22 | vsHornets | W119-93 | 20-7 | .741 | TD Garden · Boston, MA |
| 28 | Wed Dec 25 | atRaptors | W118-102 | 21-7 | .750 | Scotiabank Arena · Toronto, ON |
| 29 | Fri Dec 27 | vsCavaliers | W129-117 | 22-7 | .759 | TD Garden · Boston, MA |
| 30 | Sat Dec 28 | vsRaptors | L97-113 | 22-8 | .733 | TD Garden · Boston, MA |
| 31 | Tue Dec 31 | atHornets | W109-92 | 23-8 | .742 | Spectrum Center · Charlotte, NC |
| 32 | Fri Jan 3 | vs Hawks | W109-106 | 24-8 | .750 | TD Garden · Boston, MA |
| 33 | Sat Jan 4 | at Bulls | W111-104 | 25-8 | .758 | United Center · Chicago, IL |
| 34 | Mon Jan 6 | atWizards | L94-99 | 25-9 | .735 | Capital One Arena · Washington, D.C. |
| 35 | Wed Jan 8 | vsSpurs | L114-129 | 25-10 | .714 | TD Garden · Boston, MA |
| 36 | Thu Jan 9 | at76ers | L98-109 | 25-11 | .694 | Wells Fargo Center · Philadelphia, PA |
| 37 | Sat Jan 11 | vs Pelicans | W140-105 | 26-11 | .703 | TD Garden · Boston, MA |
| 38 | Mon Jan 13 | vsBulls | W113-101 | 27-11 | .711 | TD Garden · Boston, MA |
| 39 | Wed Jan 15 | vsPistons | L103-116 | 27-12 | .692 | TD Garden · Boston, MA |
| 40 | Thu Jan 16 | atBucks | L123-128 | 27-13 | .675 | Fiserv Forum · Milwaukee, WI |
| 41 | Sat Jan 18 | vsSuns | L119-123 | 27-14 | .659 | TD Garden · Boston, MA |
| 42 | Mon Jan 20 | vs Lakers | W139-107 | 28-14 | .667 | TD Garden · Boston, MA |
| 43 | Wed Jan 22 | vs Grizzlies | W119-95 | 29-14 | .674 | TD Garden · Boston, MA |
| 44 | Fri Jan 24 | at Magic | W109-98 | 30-14 | .682 | Amway Center · Orlando, FL |
| 45 | Sun Jan 26 | atPelicans | L108-123 | 30-15 | .667 | Smoothie King Center · New Orleans, LA |
| 46 | Tue Jan 28 | atHeat | W109-101 | 31-15 | .674 | FTX Arena · Miami, FL |
| 47 | Thu Jan 30 | vsWarriors | W119-104 | 32-15 | .681 | TD Garden · Boston, MA |
| 48 | Sat Feb 1 | vs76ers | W116-95 | 33-15 | .688 | TD Garden · Boston, MA |
| 49 | Mon Feb 3 | atHawks | W123-115 | 34-15 | .694 | State Farm Arena · Atlanta, GA |
| 50 | Wed Feb 5 | vsMagic | W116-100 | 35-15 | .700 | TD Garden · Boston, MA |
| 51 | Fri Feb 7 | vsHawks | W112-107 | 36-15 | .706 | TD Garden · Boston, MA |
| 52 | Sun Feb 9 | at Thunder | W112-111 | 37-15 | .712 | Paycom Center · Oklahoma City, OK |
| 53 | Tue Feb 11 | at Rockets | L105-116 | 37-16 | .698 | Toyota Center · Houston, TX |
| 54 | Thu Feb 13 | vsClippers | W141-133 (2OT) | 38-16 | .704 | TD Garden · Boston, MA |
| 55 | Fri Feb 21 | at T-wolves | W127-117 | 39-16 | .709 | Target Center · Minneapolis, MN |
| 56 | Sun Feb 23 | atLakers | L112-114 | 39-17 | .696 | Crypto.com Arena · Los Angeles, CA |
| 57 | Tue Feb 25 | at Blazers | W118-106 | 40-17 | .702 | Moda Center · Portland, OR |
| 58 | Wed Feb 26 | at Jazz | W114-103 | 41-17 | .707 | Vivint Arena · Salt Lake City, UT |
| 59 | Sat Feb 29 | vsRockets | L110-111 (OT) | 41-18 | .695 | TD Garden · Boston, MA |
| 60 | Tue Mar 3 | vsNets | L120-129 (OT) | 41-19 | .683 | TD Garden · Boston, MA |
| 61 | Wed Mar 4 | atCavaliers | W112-106 | 42-19 | .689 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 62 | Fri Mar 6 | vsJazz | L94-99 | 42-20 | .677 | TD Garden · Boston, MA |
| 63 | Sun Mar 8 | vsThunder | L104-105 | 42-21 | .667 | TD Garden · Boston, MA |
| 64 | Tue Mar 10 | atPacers | W114-111 | 43-21 | .672 | Gainbridge Fieldhouse · Indianapolis, IN |
| 65 | Fri Jul 31 | atBucks | L112-119 | 43-22 | .662 | Fiserv Forum · Milwaukee, WI |
| 66 | Sun Aug 2 | vsBlazers | W128-124 | 44-22 | .667 | TD Garden · Boston, MA |
| 67 | Tue Aug 4 | atHeat | L106-112 | 44-23 | .657 | FTX Arena · Miami, FL |
| 68 | Wed Aug 5 | vsNets | W149-115 | 45-23 | .662 | TD Garden · Boston, MA |
| 69 | Fri Aug 7 | atRaptors | W122-100 | 46-23 | .667 | Scotiabank Arena · Toronto, ON |
| 70 | Sun Aug 9 | vsMagic | W122-119 (OT) | 47-23 | .671 | TD Garden · Boston, MA |
| 71 | Tue Aug 11 | atGrizzlies | W122-107 | 48-23 | .676 | FedExForum · Memphis, TN |
| 72 | Thu Aug 13 | vsWizards | L90-96 | 48-24 | .667 | TD Garden · Boston, MA |
| 1 | Mon Aug 17 | vs76ers | W109-101 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Wed Aug 19 | vs76ers | W128-101 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Fri Aug 21 | at76ers | W102-94 | 3-0 | 1.000 | Wells Fargo Center · Philadelphia, PA |
| 4 | Sun Aug 23 | at76ers | W110-106 | 4-0 | 1.000 | Wells Fargo Center · Philadelphia, PA |
| 1 | Sun Aug 30 | atRaptors | W112-94 | 1-0 | 1.000 | Scotiabank Arena · Toronto, ON |
| 2 | Tue Sep 1 | atRaptors | W102-99 | 2-0 | 1.000 | Scotiabank Arena · Toronto, ON |
| 3 | Thu Sep 3 | vsRaptors | L103-104 | 2-1 | .667 | TD Garden · Boston, MA |
| 4 | Sat Sep 5 | vsRaptors | L93-100 | 2-2 | .500 | TD Garden · Boston, MA |
| 5 | Mon Sep 7 | atRaptors | W111-89 | 3-2 | .600 | Scotiabank Arena · Toronto, ON |
| 6 | Wed Sep 9 | vsRaptors | L122-125 (2OT) | 3-3 | .500 | TD Garden · Boston, MA |
| 7 | Fri Sep 11 | atRaptors | W92-87 | 4-3 | .571 | Scotiabank Arena · Toronto, ON |
| 1 | Tue Sep 15 | vsHeat | L114-117 (OT) | 0-1 | .000 | TD Garden · Boston, MA |
| 2 | Thu Sep 17 | vsHeat | L101-106 | 0-2 | .000 | TD Garden · Boston, MA |
| 3 | Sat Sep 19 | atHeat | W117-106 | 1-2 | .333 | FTX Arena · Miami, FL |
| 4 | Wed Sep 23 | atHeat | L109-112 | 1-3 | .250 | FTX Arena · Miami, FL |
| 5 | Fri Sep 25 | vsHeat | W121-108 | 2-3 | .400 | TD Garden · Boston, MA |
| 6 | Sun Sep 27 | atHeat | L113-125 | 2-4 | .333 | FTX Arena · Miami, FL |
