| 1 | Thu Oct 23 | at Warriors | L131-137 (OT) | 0-1 | .000 | ESPN | Chase Center · San Francisco, CA |
| 2 | Sat Oct 25 | vsSuns | W133-111 | 1-1 | .500 | | Ball Arena · Denver, CO |
| 3 | Mon Oct 27 | atT-wolves | W127-114 | 2-1 | .667 | Peacock | Target Center · Minneapolis, MN |
| 4 | Wed Oct 29 | vsPelicans | W122-88 | 3-1 | .750 | | Ball Arena · Denver, CO |
| 5 | Fri Oct 31 | atBlazers | L107-109 | 3-2 | .600 | | Moda Center · Portland, OR |
| 6 | Mon Nov 3 | vsKings | W130-124 | 4-2 | .667 | | Ball Arena · Denver, CO |
| 7 | Wed Nov 5 | vsHeat | W122-112 | 5-2 | .714 | | Ball Arena · Denver, CO |
| 8 | Fri Nov 7 | vsWarriors | W129-104 | 6-2 | .750 | Amazon | Ball Arena · Denver, CO |
| 9 | Sat Nov 8 | vsPacers | W117-100 | 7-2 | .778 | | Ball Arena · Denver, CO |
| 10 | Tue Nov 11 | atKings | W122-108 | 8-2 | .800 | Peacock | Golden 1 Center · Sacramento, CA |
| 11 | Wed Nov 12 | atClippers | W130-116 | 9-2 | .818 | | Intuit Dome · Inglewood, CA |
| 12 | Sat Nov 15 | atT-wolves | W123-112 | 10-2 | .833 | | Target Center · Minneapolis, MN |
| 13 | Mon Nov 17 | vsBulls | L127-130 | 10-3 | .769 | | Ball Arena · Denver, CO |
| 14 | Wed Nov 19 | atPelicans | W125-118 | 11-3 | .786 | | Smoothie King Center · New Orleans, LA |
| 15 | Fri Nov 21 | atRockets | W112-109 | 12-3 | .800 | Amazon | Toyota Center · Houston, TX |
| 16 | Sat Nov 22 | vsKings | L123-128 | 12-4 | .750 | | Ball Arena · Denver, CO |
| 17 | Mon Nov 24 | atGrizzlies | W125-115 | 13-4 | .765 | | FedExForum · Memphis, TN |
| 18 | Fri Nov 28 | vsSpurs | L136-139 | 13-5 | .722 | | Ball Arena · Denver, CO |
| 19 | Sat Nov 29 | atSuns | W130-112 | 14-5 | .737 | | Mortgage Matchup Center · Phoenix, AZ |
| 20 | Mon Dec 1 | vsMavericks | L121-131 | 14-6 | .700 | | Ball Arena · Denver, CO |
| 21 | Wed Dec 3 | atPacers | W135-120 | 15-6 | .714 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 22 | Fri Dec 5 | atHawks | W134-133 | 16-6 | .727 | | State Farm Arena · Atlanta, GA |
| 23 | Sun Dec 7 | atHornets | W115-106 | 17-6 | .739 | | Spectrum Center · Charlotte, NC |
| 24 | Thu Dec 11 | atKings | W136-105 | 18-6 | .750 | | Golden 1 Center · Sacramento, CA |
| 25 | Mon Dec 15 | vsRockets | W128-125 (OT) | 19-6 | .760 | Peacock | Ball Arena · Denver, CO |
| 26 | Thu Dec 18 | vsMagic | W126-115 | 20-6 | .769 | | Ball Arena · Denver, CO |
| 27 | Sat Dec 20 | vsRockets | L101-115 | 20-7 | .741 | NBA TV | Ball Arena · Denver, CO |
| 28 | Mon Dec 22 | vsJazz | W135-112 | 21-7 | .750 | | Ball Arena · Denver, CO |
| 29 | Tue Dec 23 | atMavericks | L130-131 | 21-8 | .724 | Peacock | American Airlines Center · Dallas, TX |
| 30 | Thu Dec 25 | vsT-wolves | W142-138 (OT) | 22-8 | .733 | ESPN | Ball Arena · Denver, CO |
| 31 | Sat Dec 27 | atMagic | L126-127 | 22-9 | .710 | | Kia Center · Orlando, FL |
| 32 | Mon Dec 29 | atHeat | L123-147 | 22-10 | .688 | | Kaseya Center · Miami, FL |
| 33 | Wed Dec 31 | atRaptors | W106-103 | 23-10 | .697 | | Scotiabank Arena · Toronto, ON |
| 34 | Fri Jan 2 | atCavaliers | L108-113 | 23-11 | .676 | Amazon | Rocket Mortgage FieldHouse · Cleveland, OH |
| 35 | Sun Jan 4 | atNets | L115-127 | 23-12 | .657 | | Barclays Center · Brooklyn, NY |
| 36 | Mon Jan 5 | at76ers | W125-124 (OT) | 24-12 | .667 | Peacock | Wells Fargo Center · Philadelphia, PA |
| 37 | Wed Jan 7 | atCeltics | W114-110 | 25-12 | .676 | ESPN | TD Garden · Boston, MA |
| 38 | Fri Jan 9 | vsHawks | L87-110 | 25-13 | .658 | | Ball Arena · Denver, CO |
| 39 | Sun Jan 11 | vsBucks | W108-104 | 26-13 | .667 | | Ball Arena · Denver, CO |
| 40 | Tue Jan 13 | atPelicans | W122-116 | 27-13 | .675 | | Smoothie King Center · New Orleans, LA |
| 41 | Wed Jan 14 | atMavericks | W118-109 | 28-13 | .683 | ESPN | American Airlines Center · Dallas, TX |
| 42 | Sat Jan 17 | vsWizards | W121-115 | 29-13 | .690 | | Ball Arena · Denver, CO |
| 43 | Sun Jan 18 | vsHornets | L87-110 | 29-14 | .674 | | Ball Arena · Denver, CO |
| 44 | Tue Jan 20 | vsLakers | L107-115 | 29-15 | .659 | Peacock | Ball Arena · Denver, CO |
| 45 | Thu Jan 22 | atWizards | W107-97 | 30-15 | .667 | | Capital One Arena · Washington, D.C. |
| 46 | Fri Jan 23 | atBucks | W102-100 | 31-15 | .674 | Amazon | Fiserv Forum · Milwaukee, WI |
| 47 | Tue Jan 27 | vsPistons | L107-109 | 31-16 | .660 | | Ball Arena · Denver, CO |
| 48 | Thu Jan 29 | vsNets | W107-103 | 32-16 | .667 | | Ball Arena · Denver, CO |
| 49 | Fri Jan 30 | vsClippers | W122-109 | 33-16 | .673 | | Ball Arena · Denver, CO |
| 50 | Sun Feb 1 | vsThunder | L111-121 | 33-17 | .660 | Peacock | Ball Arena · Denver, CO |
| 51 | Tue Feb 3 | atPistons | L121-124 | 33-18 | .647 | | Little Caesars Arena · Detroit, MI |
| 52 | Wed Feb 4 | atKnicks | L127-134 (2OT) | 33-19 | .635 | ESPN | Madison Square Garden · Manhattan, NY |
| 53 | Sat Feb 7 | atBulls | W136-120 | 34-19 | .642 | | United Center · Chicago, IL |
| 54 | Mon Feb 9 | vsCavaliers | L117-119 | 34-20 | .630 | | Ball Arena · Denver, CO |
| 55 | Wed Feb 11 | vsGrizzlies | W122-116 | 35-20 | .636 | | Ball Arena · Denver, CO |
| --all-star break-- |
| 56 | Thu Feb 19 | atClippers | L114-115 | 35-21 | .625 | | Intuit Dome · Inglewood, CA |
| 57 | Fri Feb 20 | atBlazers | W157-103 | 36-21 | .632 | | Moda Center · Portland, OR |
| 58 | Sun Feb 22 | atWarriors | L117-128 | 36-22 | .621 | ABC | Chase Center · San Francisco, CA |
| 59 | Wed Feb 25 | vsCeltics | W103-84 | 37-22 | .627 | ESPN | Ball Arena · Denver, CO |
| 60 | Fri Feb 27 | atThunder | L121-127 (OT) | 37-23 | .617 | ESPN | Paycom Center · Oklahoma City, OK |
| 61 | Sun Mar 1 | vsT-wolves | L108-117 | 37-24 | .607 | ABC | Ball Arena · Denver, CO |
| 62 | Mon Mar 2 | atJazz | W128-125 | 38-24 | .613 | | Vivint Arena · Salt Lake City, UT |
