| 1 | Wed Oct 18 | at Grizzlies | L91-103 | 0-1 | .000 | | FedExForum · Memphis, TN |
| 2 | Fri Oct 20 | vs Warriors | L120-128 | 0-2 | .000 | ESPN | Smoothie King Center · New Orleans, LA |
| 3 | Sun Oct 22 | at Lakers | W119-112 | 1-2 | .333 | | Crypto.com Arena · Los Angeles, CA |
| 4 | Tue Oct 24 | at Blazers | L93-103 | 1-3 | .250 | NBA TV | Moda Center · Portland, OR |
| 5 | Thu Oct 26 | at Kings | W114-106 | 2-3 | .400 | TNT | Golden 1 Center · Sacramento, CA |
| 6 | Sat Oct 28 | vs Cavaliers | W123-101 | 3-3 | .500 | | Smoothie King Center · New Orleans, LA |
| 7 | Mon Oct 30 | vs Magic | L99-115 | 3-4 | .429 | | Smoothie King Center · New Orleans, LA |
| 8 | Wed Nov 1 | vs T-wolves | L98-104 | 3-5 | .375 | | Smoothie King Center · New Orleans, LA |
| 9 | Fri Nov 3 | at Mavericks | W99-94 | 4-5 | .444 | | American Airlines Center · Dallas, TX |
| 10 | Sat Nov 4 | at Bulls | W96-90 (OT) | 5-5 | .500 | | United Center · Chicago, IL |
| 11 | Tue Nov 7 | at Pacers | W117-112 | 6-5 | .545 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 12 | Thu Nov 9 | at Raptors | L118-122 | 6-6 | .500 | | Scotiabank Arena · Toronto, ON |
| 13 | Sat Nov 11 | vs Clippers | W111-103 | 7-6 | .538 | | Smoothie King Center · New Orleans, LA |
| 14 | Mon Nov 13 | vs Hawks | W106-105 | 8-6 | .571 | | Smoothie King Center · New Orleans, LA |
| 15 | Wed Nov 15 | vs Raptors | L116-125 | 8-7 | .533 | | Smoothie King Center · New Orleans, LA |
| 16 | Fri Nov 17 | at Nuggets | L114-146 | 8-8 | .500 | ESPN | Ball Arena · Denver, CO |
| 17 | Mon Nov 20 | vs Thunder | W114-107 | 9-8 | .529 | | Smoothie King Center · New Orleans, LA |
| 18 | Wed Nov 22 | vs Spurs | W107-90 | 10-8 | .556 | | Smoothie King Center · New Orleans, LA |
| 19 | Fri Nov 24 | at Suns | W115-91 | 11-8 | .579 | | Footprint Center · Phoenix, AZ |
| 20 | Sat Nov 25 | at Warriors | L95-110 | 11-9 | .550 | | Chase Center · San Francisco, CA |
| 21 | Wed Nov 29 | vs T-wolves | L102-120 | 11-10 | .524 | | Smoothie King Center · New Orleans, LA |
| 22 | Fri Dec 1 | at Jazz | L108-114 | 11-11 | .500 | | Vivint Arena · Salt Lake City, UT |
| 23 | Sat Dec 2 | at Blazers | W123-116 | 12-11 | .522 | | Moda Center · Portland, OR |
| 24 | Mon Dec 4 | vs Warriors | L115-125 | 12-12 | .500 | | Smoothie King Center · New Orleans, LA |
| 25 | Wed Dec 6 | vs Nuggets | W123-114 | 13-12 | .520 | | Smoothie King Center · New Orleans, LA |
| 26 | Fri Dec 8 | vs Kings | L109-116 (OT) | 13-13 | .500 | | Smoothie King Center · New Orleans, LA |
| 27 | Sun Dec 10 | vs 76ers | W131-124 | 14-13 | .519 | | Smoothie King Center · New Orleans, LA |
| 28 | Mon Dec 11 | at Rockets | L123-130 | 14-14 | .500 | NBA TV | Toyota Center · Houston, TX |
| 29 | Wed Dec 13 | vs Bucks | W115-108 | 15-14 | .517 | | Smoothie King Center · New Orleans, LA |
| 30 | Fri Dec 15 | at Nuggets | L111-117 (OT) | 15-15 | .500 | | Ball Arena · Denver, CO |
| 31 | Tue Dec 19 | at Wizards | L106-116 | 15-16 | .484 | | Capital One Arena · Washington, D.C. |
| 32 | Fri Dec 22 | at Magic | W111-97 | 16-16 | .500 | | Amway Center · Orlando, FL |
| 33 | Sat Dec 23 | at Heat | W109-94 | 17-16 | .515 | | Kaseya Center · Miami, FL |
| 34 | Wed Dec 27 | vs Nets | W128-113 | 18-16 | .529 | | Smoothie King Center · New Orleans, LA |
| 35 | Fri Dec 29 | vs Mavericks | L120-128 | 18-17 | .514 | | Smoothie King Center · New Orleans, LA |
| 36 | Sat Dec 30 | vs Knicks | L103-105 | 18-18 | .500 | | Smoothie King Center · New Orleans, LA |
| 37 | Wed Jan 3 | at Jazz | W108-98 | 19-18 | .514 | | Vivint Arena · Salt Lake City, UT |
| 38 | Sat Jan 6 | at T-wolves | L98-116 | 19-19 | .500 | | Target Center · Minneapolis, MN |
| 39 | Mon Jan 8 | vs Pistons | W112-109 | 20-19 | .513 | | Smoothie King Center · New Orleans, LA |
| 40 | Wed Jan 10 | at Grizzlies | L102-105 | 20-20 | .500 | | FedExForum · Memphis, TN |
| 41 | Fri Jan 12 | vs Blazers | W119-113 | 21-20 | .512 | | Smoothie King Center · New Orleans, LA |
| 42 | Sun Jan 14 | at Knicks | W123-118 (OT) | 22-20 | .524 | | Madison Square Garden · Manhattan, NY |
| 43 | Tue Jan 16 | at Celtics | W116-113 (OT) | 23-20 | .535 | NBA TV | TD Garden · Boston, MA |
| 44 | Wed Jan 17 | at Hawks | L93-94 | 23-21 | .523 | | State Farm Arena · Atlanta, GA |
| 45 | Sat Jan 20 | vs Grizzlies | W111-104 | 24-21 | .533 | | Smoothie King Center · New Orleans, LA |
| 46 | Mon Jan 22 | vs Bulls | W132-128 (2OT) | 25-21 | .543 | | Smoothie King Center · New Orleans, LA |
| 47 | Wed Jan 24 | at Hornets | W101-96 | 26-21 | .553 | | Spectrum Center · Charlotte, NC |
| 48 | Fri Jan 26 | vs Rockets | W115-113 | 27-21 | .563 | ESPN | Smoothie King Center · New Orleans, LA |
| 49 | Sun Jan 28 | vs Clippers | L103-112 | 27-22 | .551 | | Smoothie King Center · New Orleans, LA |
| 50 | Tue Jan 30 | vs Kings | L103-114 | 27-23 | .540 | | Smoothie King Center · New Orleans, LA |
| 51 | Fri Feb 2 | at Thunder | W114-100 | 28-23 | .549 | | Paycom Center · Oklahoma City, OK |
| 52 | Sat Feb 3 | at T-wolves | L107-118 | 28-24 | .538 | | Target Center · Minneapolis, MN |
| 53 | Mon Feb 5 | vs Jazz | L109-133 | 28-25 | .528 | | Smoothie King Center · New Orleans, LA |
| 54 | Fri Feb 9 | at 76ers | L82-100 | 28-26 | .519 | | Wells Fargo Center · Philadelphia, PA |
| 55 | Sat Feb 10 | at Nets | W138-128 (2OT) | 29-26 | .527 | | Barclays Center · Brooklyn, NY |
| 56 | Mon Feb 12 | at Pistons | W118-103 | 30-26 | .536 | | Little Caesars Arena · Detroit, MI |
| 57 | Wed Feb 14 | vs Lakers | W139-117 | 31-26 | .544 | | Smoothie King Center · New Orleans, LA |
| 58 | Fri Feb 23 | vs Heat | W124-123 (OT) | 32-26 | .552 | | Smoothie King Center · New Orleans, LA |
| 59 | Sun Feb 25 | at Bucks | W123-121 (OT) | 33-26 | .559 | | Fiserv Forum · Milwaukee, WI |
| 60 | Mon Feb 26 | vs Suns | W125-116 | 34-26 | .567 | | Smoothie King Center · New Orleans, LA |
| 61 | Wed Feb 28 | at Spurs | W121-116 | 35-26 | .574 | | AT&T Center · San Antonio, TX |
| 62 | Sun Mar 4 | at Mavericks | W126-109 | 36-26 | .581 | | American Airlines Center · Dallas, TX |
| 63 | Tue Mar 6 | at Clippers | W121-116 | 37-26 | .587 | TNT | Intuit Dome · Inglewood, CA |
| 64 | Wed Mar 7 | at Kings | W114-101 | 38-26 | .594 | | Golden 1 Center · Sacramento, CA |
| 65 | Fri Mar 9 | vs Wizards | L97-116 | 38-27 | .585 | NBA TV | Smoothie King Center · New Orleans, LA |
| 66 | Sun Mar 11 | vs Jazz | L99-116 | 38-28 | .576 | | Smoothie King Center · New Orleans, LA |
| 67 | Tue Mar 13 | vs Hornets | W119-115 | 39-28 | .582 | | Smoothie King Center · New Orleans, LA |
| 68 | Thu Mar 15 | at Spurs | L93-98 | 39-29 | .574 | | AT&T Center · San Antonio, TX |
| 69 | Sat Mar 17 | vs Rockets | L101-107 | 39-30 | .565 | | Smoothie King Center · New Orleans, LA |
| 70 | Sun Mar 18 | vs Celtics | W108-89 | 40-30 | .571 | | Smoothie King Center · New Orleans, LA |
| 71 | Tue Mar 20 | vs Mavericks | W115-105 | 41-30 | .577 | | Smoothie King Center · New Orleans, LA |
| 72 | Wed Mar 21 | vs Pacers | W96-92 | 42-30 | .583 | | Smoothie King Center · New Orleans, LA |
| 73 | Thu Mar 22 | vs Lakers | W128-125 | 43-30 | .589 | | Smoothie King Center · New Orleans, LA |
| 74 | Sat Mar 24 | at Rockets | L91-114 | 43-31 | .581 | NBA TV | Toyota Center · Houston, TX |
| 75 | Tue Mar 27 | vs Blazers | L103-107 | 43-32 | .573 | | Smoothie King Center · New Orleans, LA |
| 76 | Fri Mar 30 | at Cavaliers | L102-107 | 43-33 | .566 | ESPN | Rocket Mortgage FieldHouse · Cleveland, OH |
| 77 | Sun Apr 1 | vs Thunder | L104-109 | 43-34 | .558 | NBA TV | Smoothie King Center · New Orleans, LA |
| 78 | Wed Apr 4 | vs Grizzlies | W123-95 | 44-34 | .564 | | Smoothie King Center · New Orleans, LA |
| 79 | Fri Apr 6 | at Suns | W122-103 | 45-34 | .570 | | Footprint Center · Phoenix, AZ |
| 80 | Sat Apr 7 | at Warriors | W126-120 | 46-34 | .575 | | Chase Center · San Francisco, CA |
| 81 | Mon Apr 9 | at Clippers | W113-100 | 47-34 | .580 | ESPN | Intuit Dome · Inglewood, CA |
| 82 | Wed Apr 11 | vs Spurs | W122-98 | 48-34 | .585 | | Smoothie King Center · New Orleans, LA |
| 1 | Sat Apr 14 | at Blazers | W97-95 | 1-0 | 1.000 | ESPN | Moda Center · Portland, OR |
| 2 | Tue Apr 17 | at Blazers | W111-102 | 2-0 | 1.000 | TNT | Moda Center · Portland, OR |
| 3 | Thu Apr 19 | vs Blazers | W119-102 | 3-0 | 1.000 | NBA TV | Smoothie King Center · New Orleans, LA |
| 4 | Sat Apr 21 | vs Blazers | W131-123 | 4-0 | 1.000 | TNT | Smoothie King Center · New Orleans, LA |
| 1 | Sat Apr 28 | at Warriors | L101-123 | 0-1 | .000 | TNT | Chase Center · San Francisco, CA |
| 2 | Tue May 1 | at Warriors | L116-121 | 0-2 | .000 | TNT | Chase Center · San Francisco, CA |
| 3 | Fri May 4 | vs Warriors | W119-100 | 1-2 | .333 | ESPN | Smoothie King Center · New Orleans, LA |
| 4 | Sun May 6 | vs Warriors | L92-118 | 1-3 | .250 | ABC | Smoothie King Center · New Orleans, LA |
| 5 | Tue May 8 | at Warriors | L104-113 | 1-4 | .200 | TNT | Chase Center · San Francisco, CA |