| 1 | Wed Oct 25 | at Bulls | W124-104 | 1-0 | 1.000 | | United Center · Chicago, IL |
| 2 | Fri Oct 27 | at Cavaliers | W108-105 | 2-0 | 1.000 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 3 | Sun Oct 29 | vs Nuggets | L95-128 | 2-1 | .667 | | Paycom Center · Oklahoma City, OK |
| 4 | Mon Oct 30 | vs Pistons | W124-112 | 3-1 | .750 | | Paycom Center · Oklahoma City, OK |
| 5 | Wed Nov 1 | vs Pelicans | L106-110 | 3-2 | .600 | ESPN | Paycom Center · Oklahoma City, OK |
| 6 | Fri Nov 3 | vs Warriors | L139-141 | 3-3 | .500 | | Paycom Center · Oklahoma City, OK |
| 7 | Mon Nov 6 | vs Hawks | W126-117 | 4-3 | .571 | | Paycom Center · Oklahoma City, OK |
| 8 | Wed Nov 8 | vs Cavaliers | W128-120 | 5-3 | .625 | | Paycom Center · Oklahoma City, OK |
| 9 | Fri Nov 10 | at Kings | L98-105 | 5-4 | .556 | | Golden 1 Center · Sacramento, CA |
| 10 | Sun Nov 12 | at Suns | W111-99 | 6-4 | .600 | | Footprint Center · Phoenix, AZ |
| 11 | Tue Nov 14 | vs Spurs | W123-87 | 7-4 | .636 | TNT | Paycom Center · Oklahoma City, OK |
| 12 | Thu Nov 16 | at Warriors | W128-109 | 8-4 | .667 | NBA TV | Chase Center · San Francisco, CA |
| 13 | Sat Nov 18 | at Warriors | W130-123 (OT) | 9-4 | .692 | | Chase Center · San Francisco, CA |
| 14 | Sun Nov 19 | at Blazers | W134-91 | 10-4 | .714 | | Moda Center · Portland, OR |
| 15 | Wed Nov 22 | vs Bulls | W116-102 | 11-4 | .733 | | Paycom Center · Oklahoma City, OK |
| 16 | Sat Nov 25 | vs 76ers | L123-127 | 11-5 | .688 | | Paycom Center · Oklahoma City, OK |
| 17 | Tue Nov 28 | at T-wolves | L103-106 | 11-6 | .647 | | Target Center · Minneapolis, MN |
| 18 | Thu Nov 30 | vs Lakers | W133-110 | 12-6 | .667 | | Paycom Center · Oklahoma City, OK |
| 19 | Sat Dec 2 | at Mavericks | W126-120 | 13-6 | .684 | | American Airlines Center · Dallas, TX |
| 20 | Wed Dec 6 | at Rockets | L101-110 | 13-7 | .650 | | Toyota Center · Houston, TX |
| 21 | Fri Dec 8 | vs Warriors | W138-136 (OT) | 14-7 | .667 | | Paycom Center · Oklahoma City, OK |
| 22 | Mon Dec 11 | vs Jazz | W134-120 | 15-7 | .682 | | Paycom Center · Oklahoma City, OK |
| 23 | Thu Dec 14 | at Kings | L123-128 | 15-8 | .652 | | Golden 1 Center · Sacramento, CA |
| 24 | Sat Dec 16 | at Nuggets | W118-117 | 16-8 | .667 | | Ball Arena · Denver, CO |
| 25 | Mon Dec 18 | vs Grizzlies | W116-97 | 17-8 | .680 | | Paycom Center · Oklahoma City, OK |
| 26 | Thu Dec 21 | vs Clippers | W134-115 | 18-8 | .692 | | Paycom Center · Oklahoma City, OK |
| 27 | Sat Dec 23 | vs Lakers | L120-129 | 18-9 | .667 | | Paycom Center · Oklahoma City, OK |
| 28 | Tue Dec 26 | vs T-wolves | W129-106 | 19-9 | .679 | | Paycom Center · Oklahoma City, OK |
| 29 | Wed Dec 27 | vs Knicks | W129-120 | 20-9 | .690 | | Paycom Center · Oklahoma City, OK |
| 30 | Fri Dec 29 | at Nuggets | W119-93 | 21-9 | .700 | | Ball Arena · Denver, CO |
| 31 | Sun Dec 31 | vs Nets | W124-108 | 22-9 | .710 | | Paycom Center · Oklahoma City, OK |
| 32 | Tue Jan 2 | vs Celtics | W127-123 | 23-9 | .719 | | Paycom Center · Oklahoma City, OK |
| 33 | Wed Jan 3 | at Hawks | L138-141 | 23-10 | .697 | | State Farm Arena · Atlanta, GA |
| 34 | Fri Jan 5 | at Nets | L115-124 | 23-11 | .676 | | Barclays Center · Brooklyn, NY |
| 35 | Mon Jan 8 | at Wizards | W136-128 | 24-11 | .686 | | Capital One Arena · Washington, D.C. |
| 36 | Wed Jan 10 | at Heat | W128-120 | 25-11 | .694 | | Kaseya Center · Miami, FL |
| 37 | Thu Jan 11 | vs Blazers | W139-77 | 26-11 | .703 | | Paycom Center · Oklahoma City, OK |
| 38 | Sat Jan 13 | vs Magic | W112-100 | 27-11 | .711 | | Paycom Center · Oklahoma City, OK |
| 39 | Mon Jan 15 | at Lakers | L105-112 | 27-12 | .692 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 40 | Tue Jan 16 | at Clippers | L117-128 | 27-13 | .675 | TNT | Intuit Dome · Inglewood, CA |
| 41 | Thu Jan 18 | at Jazz | W134-129 | 28-13 | .683 | | Vivint Arena · Salt Lake City, UT |
| 42 | Sat Jan 20 | at T-wolves | W102-97 | 29-13 | .690 | | Target Center · Minneapolis, MN |
| 43 | Tue Jan 23 | vs Blazers | W111-109 | 30-13 | .698 | | Paycom Center · Oklahoma City, OK |
| 44 | Wed Jan 24 | at Spurs | W140-114 | 31-13 | .705 | ESPN | AT&T Center · San Antonio, TX |
| 45 | Fri Jan 26 | at Pelicans | W107-83 | 32-13 | .711 | | Smoothie King Center · New Orleans, LA |
| 46 | Sun Jan 28 | at Pistons | L104-120 | 32-14 | .696 | | Little Caesars Arena · Detroit, MI |
| 47 | Mon Jan 29 | vs T-wolves | L101-107 | 32-15 | .681 | | Paycom Center · Oklahoma City, OK |
| 48 | Wed Jan 31 | vs Nuggets | W105-100 | 33-15 | .688 | | Paycom Center · Oklahoma City, OK |
| 49 | Fri Feb 2 | vs Hornets | W126-106 | 34-15 | .694 | | Paycom Center · Oklahoma City, OK |
| 50 | Sun Feb 4 | vs Raptors | W135-127 (2OT) | 35-15 | .700 | | Paycom Center · Oklahoma City, OK |
| 51 | Tue Feb 6 | at Jazz | L117-124 | 35-16 | .686 | | Vivint Arena · Salt Lake City, UT |
| 52 | Sat Feb 10 | at Mavericks | L111-146 | 35-17 | .673 | NBA TV | American Airlines Center · Dallas, TX |
| 53 | Sun Feb 11 | vs Kings | W127-113 | 36-17 | .679 | | Paycom Center · Oklahoma City, OK |
| 54 | Tue Feb 13 | at Magic | W127-113 | 37-17 | .685 | TNT | Amway Center · Orlando, FL |
| --all-star break-- |
| 55 | Thu Feb 22 | vs Clippers | W129-107 | 38-17 | .691 | | Paycom Center · Oklahoma City, OK |
| 56 | Fri Feb 23 | vs Wizards | W147-106 | 39-17 | .696 | | Paycom Center · Oklahoma City, OK |
| 57 | Sun Feb 25 | at Rockets | W123-110 | 40-17 | .702 | | Toyota Center · Houston, TX |
| 58 | Tue Feb 27 | vs Rockets | W112-95 | 41-17 | .707 | TNT | Paycom Center · Oklahoma City, OK |
| 59 | Thu Feb 29 | at Spurs | L118-132 | 41-18 | .695 | | AT&T Center · San Antonio, TX |
| 60 | Sun Mar 3 | at Suns | W118-110 | 42-18 | .700 | ESPN | Footprint Center · Phoenix, AZ |
| 61 | Mon Mar 4 | at Lakers | L104-116 | 42-19 | .689 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 62 | Wed Mar 6 | at Blazers | W128-120 | 43-19 | .694 | | Moda Center · Portland, OR |
| 63 | Fri Mar 8 | vs Heat | W107-100 | 44-19 | .698 | | Paycom Center · Oklahoma City, OK |
| 64 | Sun Mar 10 | vs Grizzlies | W124-93 | 45-19 | .703 | | Paycom Center · Oklahoma City, OK |
| 65 | Tue Mar 12 | vs Pacers | L111-121 | 45-20 | .692 | | Paycom Center · Oklahoma City, OK |
| 66 | Thu Mar 14 | vs Mavericks | W126-119 | 46-20 | .697 | TNT | Paycom Center · Oklahoma City, OK |
| 67 | Sat Mar 16 | at Grizzlies | W118-112 | 47-20 | .701 | | FedExForum · Memphis, TN |
| 68 | Wed Mar 20 | vs Jazz | W119-107 | 48-20 | .706 | | Paycom Center · Oklahoma City, OK |
| 69 | Fri Mar 22 | at Raptors | W123-103 | 49-20 | .710 | | Scotiabank Arena · Toronto, ON |
| 70 | Sun Mar 24 | at Bucks | L93-118 | 49-21 | .700 | NBA TV | Fiserv Forum · Milwaukee, WI |
| 71 | Tue Mar 26 | at Pelicans | W119-112 | 50-21 | .704 | | Smoothie King Center · New Orleans, LA |
| 72 | Wed Mar 27 | vs Rockets | L126-132 (OT) | 50-22 | .694 | | Paycom Center · Oklahoma City, OK |
| 73 | Fri Mar 29 | vs Suns | W128-103 | 51-22 | .699 | | Paycom Center · Oklahoma City, OK |
| 74 | Sun Mar 31 | at Knicks | W113-112 | 52-22 | .703 | | Madison Square Garden · Manhattan, NY |
| 75 | Tue Apr 2 | at 76ers | L105-109 | 52-23 | .693 | TNT | Wells Fargo Center · Philadelphia, PA |
| 76 | Wed Apr 3 | at Celtics | L100-135 | 52-24 | .684 | ESPN | TD Garden · Boston, MA |
| 77 | Fri Apr 5 | at Pacers | L112-126 | 52-25 | .675 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 78 | Sun Apr 7 | at Hornets | W121-118 | 53-25 | .679 | | Spectrum Center · Charlotte, NC |
| 79 | Tue Apr 9 | vs Kings | W112-105 | 54-25 | .684 | | Paycom Center · Oklahoma City, OK |
| 80 | Wed Apr 10 | vs Spurs | W127-89 | 55-25 | .688 | | Paycom Center · Oklahoma City, OK |
| 81 | Fri Apr 12 | vs Bucks | W125-107 | 56-25 | .691 | NBA TV | Paycom Center · Oklahoma City, OK |
| 82 | Sun Apr 14 | vs Mavericks | W135-86 | 57-25 | .695 | | Paycom Center · Oklahoma City, OK |
| 1 | Sun Apr 21 | vs Pelicans | W94-92 | 1-0 | 1.000 | TNT | Paycom Center · Oklahoma City, OK |
| 2 | Wed Apr 24 | vs Pelicans | W124-92 | 2-0 | 1.000 | TNT | Paycom Center · Oklahoma City, OK |
| 3 | Sat Apr 27 | at Pelicans | W106-85 | 3-0 | 1.000 | TNT | Smoothie King Center · New Orleans, LA |
| 4 | Mon Apr 29 | at Pelicans | W97-89 | 4-0 | 1.000 | NBA TV | Smoothie King Center · New Orleans, LA |
| 1 | Tue May 7 | vs Mavericks | W117-95 | 1-0 | 1.000 | TNT | Paycom Center · Oklahoma City, OK |
| 2 | Thu May 9 | vs Mavericks | L110-119 | 1-1 | .500 | ESPN | Paycom Center · Oklahoma City, OK |
| 3 | Sat May 11 | at Mavericks | L101-105 | 1-2 | .333 | ABC | American Airlines Center · Dallas, TX |
| 4 | Mon May 13 | at Mavericks | W100-96 | 2-2 | .500 | TNT | American Airlines Center · Dallas, TX |
| 5 | Wed May 15 | vs Mavericks | L92-104 | 2-3 | .400 | TNT | Paycom Center · Oklahoma City, OK |
| 6 | Sat May 18 | at Mavericks | L116-117 | 2-4 | .333 | ABC | American Airlines Center · Dallas, TX |