| 1 | Wed Oct 23 | at Jazz | L95-100 | 0-1 | .000 | | Vivint Arena · Salt Lake City, UT |
| 2 | Fri Oct 25 | vs Wizards | L85-97 | 0-2 | .000 | | Paycom Center · Oklahoma City, OK |
| 3 | Sun Oct 27 | vs Warriors | W120-92 | 1-2 | .333 | | Paycom Center · Oklahoma City, OK |
| 4 | Mon Oct 28 | at Rockets | L112-116 | 1-3 | .250 | | Toyota Center · Houston, TX |
| 5 | Wed Oct 30 | vs Blazers | L99-102 | 1-4 | .200 | | Paycom Center · Oklahoma City, OK |
| 6 | Sat Nov 2 | vs Pelicans | W115-104 | 2-4 | .333 | | Paycom Center · Oklahoma City, OK |
| 7 | Tue Nov 5 | vs Magic | W102-94 | 3-4 | .429 | | Paycom Center · Oklahoma City, OK |
| 8 | Thu Nov 7 | at Spurs | L112-121 | 3-5 | .375 | | AT&T Center · San Antonio, TX |
| 9 | Sat Nov 9 | vs Warriors | W114-108 | 4-5 | .444 | | Paycom Center · Oklahoma City, OK |
| 10 | Sun Nov 10 | vs Bucks | L119-121 | 4-6 | .400 | | Paycom Center · Oklahoma City, OK |
| 11 | Tue Nov 12 | at Pacers | L85-111 | 4-7 | .364 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 12 | Fri Nov 15 | vs 76ers | W127-119 (OT) | 5-7 | .417 | | Paycom Center · Oklahoma City, OK |
| 13 | Mon Nov 18 | at Clippers | L88-90 | 5-8 | .385 | | Intuit Dome · Inglewood, CA |
| 14 | Tue Nov 19 | at Lakers | L107-112 | 5-9 | .357 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 15 | Fri Nov 22 | vs Lakers | L127-130 | 5-10 | .333 | | Paycom Center · Oklahoma City, OK |
| 16 | Mon Nov 25 | at Warriors | W100-97 | 6-10 | .375 | NBA TV | Chase Center · San Francisco, CA |
| 17 | Wed Nov 27 | at Blazers | L119-136 | 6-11 | .353 | | Moda Center · Portland, OR |
| 18 | Fri Nov 29 | vs Pelicans | W109-104 | 7-11 | .389 | NBA TV | Paycom Center · Oklahoma City, OK |
| 19 | Sun Dec 1 | at Pelicans | W107-104 | 8-11 | .421 | | Smoothie King Center · New Orleans, LA |
| 20 | Wed Dec 4 | vs Pacers | L100-107 | 8-12 | .400 | | Paycom Center · Oklahoma City, OK |
| 21 | Fri Dec 6 | vs T-wolves | W139-127 (OT) | 9-12 | .429 | | Paycom Center · Oklahoma City, OK |
| 22 | Sun Dec 8 | at Blazers | W108-96 | 10-12 | .455 | | Moda Center · Portland, OR |
| 23 | Mon Dec 9 | at Jazz | W104-90 | 11-12 | .478 | | Vivint Arena · Salt Lake City, UT |
| 24 | Wed Dec 11 | at Kings | L93-94 | 11-13 | .458 | | Golden 1 Center · Sacramento, CA |
| 25 | Sat Dec 14 | at Nuggets | L102-110 | 11-14 | .440 | | Ball Arena · Denver, CO |
| 26 | Mon Dec 16 | vs Bulls | W109-106 | 12-14 | .462 | | Paycom Center · Oklahoma City, OK |
| 27 | Wed Dec 18 | vs Grizzlies | W126-122 | 13-14 | .481 | | Paycom Center · Oklahoma City, OK |
| 28 | Fri Dec 20 | vs Suns | W126-108 | 14-14 | .500 | | Paycom Center · Oklahoma City, OK |
| 29 | Sun Dec 22 | vs Clippers | W118-112 | 15-14 | .517 | NBA TV | Paycom Center · Oklahoma City, OK |
| 30 | Thu Dec 26 | vs Grizzlies | L97-110 | 15-15 | .500 | | Paycom Center · Oklahoma City, OK |
| 31 | Fri Dec 27 | at Hornets | W104-102 (OT) | 16-15 | .516 | | Spectrum Center · Charlotte, NC |
| 32 | Sun Dec 29 | at Raptors | W98-97 | 17-15 | .531 | | Scotiabank Arena · Toronto, ON |
| 33 | Tue Dec 31 | vs Mavericks | W106-101 | 18-15 | .545 | | Paycom Center · Oklahoma City, OK |
| 34 | Thu Jan 2 | at Spurs | W109-103 | 19-15 | .559 | | AT&T Center · San Antonio, TX |
| 35 | Sat Jan 4 | at Cavaliers | W121-106 | 20-15 | .571 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 36 | Mon Jan 6 | at 76ers | L113-120 | 20-16 | .556 | NBA TV | Wells Fargo Center · Philadelphia, PA |
| 37 | Tue Jan 7 | at Nets | W111-103 (OT) | 21-16 | .568 | NBA TV | Barclays Center · Brooklyn, NY |
| 38 | Thu Jan 9 | vs Rockets | W113-92 | 22-16 | .579 | TNT | Paycom Center · Oklahoma City, OK |
| 39 | Sat Jan 11 | vs Lakers | L110-125 | 22-17 | .564 | | Paycom Center · Oklahoma City, OK |
| 40 | Mon Jan 13 | at T-wolves | W117-104 | 23-17 | .575 | | Target Center · Minneapolis, MN |
| 41 | Wed Jan 15 | vs Raptors | L121-130 | 23-18 | .561 | | Paycom Center · Oklahoma City, OK |
| 42 | Fri Jan 17 | vs Heat | L108-115 | 23-19 | .548 | | Paycom Center · Oklahoma City, OK |
| 43 | Sat Jan 18 | vs Blazers | W119-106 | 24-19 | .558 | | Paycom Center · Oklahoma City, OK |
| 44 | Mon Jan 20 | at Rockets | W112-107 | 25-19 | .568 | | Toyota Center · Houston, TX |
| 45 | Wed Jan 22 | at Magic | W120-114 | 26-19 | .578 | | Amway Center · Orlando, FL |
| 46 | Fri Jan 24 | vs Hawks | W140-111 | 27-19 | .587 | | Paycom Center · Oklahoma City, OK |
| 47 | Sat Jan 25 | at T-wolves | W113-104 | 28-19 | .596 | | Target Center · Minneapolis, MN |
| 48 | Mon Jan 27 | vs Mavericks | L97-107 | 28-20 | .583 | | Paycom Center · Oklahoma City, OK |
| 49 | Wed Jan 29 | at Kings | W120-100 | 29-20 | .592 | | Golden 1 Center · Sacramento, CA |
| 50 | Fri Jan 31 | at Suns | W111-107 | 30-20 | .600 | | Footprint Center · Phoenix, AZ |
| 51 | Wed Feb 5 | vs Cavaliers | W109-103 | 31-20 | .608 | | Paycom Center · Oklahoma City, OK |
| 52 | Fri Feb 7 | vs Pistons | W108-101 | 32-20 | .615 | | Paycom Center · Oklahoma City, OK |
| 53 | Sun Feb 9 | vs Celtics | L111-112 | 32-21 | .604 | NBA TV | Paycom Center · Oklahoma City, OK |
| 54 | Tue Feb 11 | vs Spurs | L106-114 | 32-22 | .593 | | Paycom Center · Oklahoma City, OK |
| 55 | Thu Feb 13 | at Pelicans | W123-118 | 33-22 | .600 | | Smoothie King Center · New Orleans, LA |
| 56 | Fri Feb 21 | vs Nuggets | W113-101 | 34-22 | .607 | ESPN | Paycom Center · Oklahoma City, OK |
| 57 | Sun Feb 23 | vs Spurs | W131-103 | 35-22 | .614 | | Paycom Center · Oklahoma City, OK |
| 58 | Tue Feb 25 | at Bulls | W124-122 | 36-22 | .621 | | United Center · Chicago, IL |
| 59 | Thu Feb 27 | vs Kings | W112-108 | 37-22 | .627 | | Paycom Center · Oklahoma City, OK |
| 60 | Fri Feb 28 | at Bucks | L86-133 | 37-23 | .617 | ESPN | Fiserv Forum · Milwaukee, WI |
| 61 | Tue Mar 3 | vs Clippers | L94-109 | 37-24 | .607 | | Paycom Center · Oklahoma City, OK |
| 62 | Wed Mar 4 | at Pistons | W114-107 | 38-24 | .613 | | Little Caesars Arena · Detroit, MI |
| 63 | Fri Mar 6 | at Knicks | W126-103 | 39-24 | .619 | | Madison Square Garden · Manhattan, NY |
| 64 | Sun Mar 8 | at Celtics | W105-104 | 40-24 | .625 | NBA TV | TD Garden · Boston, MA |
| 65 | Sat Aug 1 | vs Jazz | W110-94 | 41-24 | .631 | ESPN | Paycom Center · Oklahoma City, OK |
| 66 | Mon Aug 3 | vs Nuggets | L113-121 (OT) | 41-25 | .621 | NBA TV | Paycom Center · Oklahoma City, OK |
| 67 | Wed Aug 5 | at Lakers | W105-86 | 42-25 | .627 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 68 | Fri Aug 7 | at Grizzlies | L92-121 | 42-26 | .618 | NBA TV | FedExForum · Memphis, TN |
| 69 | Sun Aug 9 | vs Wizards | W121-103 | 43-26 | .623 | | Paycom Center · Oklahoma City, OK |
| 70 | Mon Aug 10 | at Suns | L101-128 | 43-27 | .614 | | Footprint Center · Phoenix, AZ |
| 71 | Wed Aug 12 | vs Heat | W116-115 | 44-27 | .620 | | Paycom Center · Oklahoma City, OK |
| 72 | Fri Aug 14 | at Clippers | L103-107 (OT) | 44-28 | .611 | ESPN | Intuit Dome · Inglewood, CA |
| 1 | Tue Aug 18 | at Rockets | L108-123 | 0-1 | .000 | TNT | Toyota Center · Houston, TX |
| 2 | Thu Aug 20 | at Rockets | L98-111 | 0-2 | .000 | ESPN | Toyota Center · Houston, TX |
| 3 | Sat Aug 22 | vs Rockets | W119-107 (OT) | 1-2 | .333 | ESPN | Paycom Center · Oklahoma City, OK |
| 4 | Mon Aug 24 | vs Rockets | W117-114 | 2-2 | .500 | TNT | Paycom Center · Oklahoma City, OK |
| 5 | Sat Aug 29 | at Rockets | L80-114 | 2-3 | .400 | TNT | Toyota Center · Houston, TX |
| 6 | Mon Aug 31 | vs Rockets | W104-100 | 3-3 | .500 | TNT | Paycom Center · Oklahoma City, OK |
| 7 | Wed Sep 2 | at Rockets | L102-104 | 3-4 | .429 | ESPN | Toyota Center · Houston, TX |