| 1 | Tue Oct 21 | vs Rockets | W125-124 (2OT) | 1-0 | 1.000 | Peacock | Paycom Center · Oklahoma City, OK |
| 2 | Thu Oct 23 | at Pacers | W141-135 (2OT) | 2-0 | 1.000 | ESPN | Gainbridge Fieldhouse · Indianapolis, IN |
| 3 | Sat Oct 25 | at Hawks | W117-100 | 3-0 | 1.000 | NBA TV | State Farm Arena · Atlanta, GA |
| 4 | Mon Oct 27 | at Mavericks | W101-94 | 4-0 | 1.000 | | American Airlines Center · Dallas, TX |
| 5 | Tue Oct 28 | vs Kings | W107-101 | 5-0 | 1.000 | | Paycom Center · Oklahoma City, OK |
| 6 | Thu Oct 30 | vs Wizards | W127-108 | 6-0 | 1.000 | | Paycom Center · Oklahoma City, OK |
| 7 | Sun Nov 2 | vs Pelicans | W137-106 | 7-0 | 1.000 | | Paycom Center · Oklahoma City, OK |
| 8 | Tue Nov 4 | at Clippers | W126-107 | 8-0 | 1.000 | Peacock | Intuit Dome · Inglewood, CA |
| 9 | Wed Nov 5 | at Blazers | L119-121 | 8-1 | .889 | | Moda Center · Portland, OR |
| 10 | Fri Nov 7 | at Kings | W132-101 | 9-1 | .900 | | Golden 1 Center · Sacramento, CA |
| 11 | Sun Nov 9 | at Grizzlies | W114-100 | 10-1 | .909 | | FedExForum · Memphis, TN |
| 12 | Tue Nov 11 | vs Warriors | W126-102 | 11-1 | .917 | | Paycom Center · Oklahoma City, OK |
| 13 | Wed Nov 12 | vs Lakers | W121-92 | 12-1 | .923 | ESPN | Paycom Center · Oklahoma City, OK |
| 14 | Sat Nov 15 | at Hornets | W109-96 | 13-1 | .929 | | Spectrum Center · Charlotte, NC |
| 15 | Mon Nov 17 | at Pelicans | W126-109 | 14-1 | .933 | | Smoothie King Center · New Orleans, LA |
| 16 | Wed Nov 19 | vs Kings | W113-99 | 15-1 | .938 | | Paycom Center · Oklahoma City, OK |
| 17 | Fri Nov 21 | at Jazz | W144-112 | 16-1 | .941 | | Vivint Arena · Salt Lake City, UT |
| 18 | Sun Nov 23 | vs Blazers | W122-95 | 17-1 | .944 | | Paycom Center · Oklahoma City, OK |
| 19 | Wed Nov 26 | vs T-wolves | W113-105 | 18-1 | .947 | ESPN | Paycom Center · Oklahoma City, OK |
| 20 | Fri Nov 28 | vs Suns | W123-119 | 19-1 | .950 | | Paycom Center · Oklahoma City, OK |
| 21 | Sun Nov 30 | at Blazers | W123-115 | 20-1 | .952 | | Moda Center · Portland, OR |
| 22 | Tue Dec 2 | at Warriors | W124-112 | 21-1 | .955 | Peacock | Chase Center · San Francisco, CA |
| 23 | Fri Dec 5 | vs Mavericks | W132-111 | 22-1 | .957 | Amazon | Paycom Center · Oklahoma City, OK |
| 24 | Sun Dec 7 | at Jazz | W131-101 | 23-1 | .958 | | Vivint Arena · Salt Lake City, UT |
| 25 | Wed Dec 10 | vs Suns | W138-89 | 24-1 | .960 | Amazon | Paycom Center · Oklahoma City, OK |
| 26 | Sat Dec 13 | vs Spurs | L109-111 | 24-2 | .923 | Amazon | Paycom Center · Oklahoma City, OK |
| 27 | Thu Dec 18 | vs Clippers | W122-101 | 25-2 | .926 | NBA TV | Paycom Center · Oklahoma City, OK |
| 28 | Fri Dec 19 | at T-wolves | L107-112 | 25-3 | .893 | Amazon | Target Center · Minneapolis, MN |
| 29 | Mon Dec 22 | vs Grizzlies | W119-103 | 26-3 | .897 | Peacock | Paycom Center · Oklahoma City, OK |
| 30 | Tue Dec 23 | at Spurs | L110-130 | 26-4 | .867 | | AT&T Center · San Antonio, TX |
| 31 | Thu Dec 25 | vs Spurs | L102-117 | 26-5 | .839 | ESPN | Paycom Center · Oklahoma City, OK |
| 32 | Sun Dec 28 | vs 76ers | W129-104 | 27-5 | .844 | | Paycom Center · Oklahoma City, OK |
| 33 | Mon Dec 29 | vs Hawks | W140-129 | 28-5 | .848 | | Paycom Center · Oklahoma City, OK |
| 34 | Wed Dec 31 | vs Blazers | W124-95 | 29-5 | .853 | | Paycom Center · Oklahoma City, OK |
| 35 | Fri Jan 2 | at Warriors | W131-94 | 30-5 | .857 | Amazon | Chase Center · San Francisco, CA |
| 36 | Sun Jan 4 | at Suns | L105-108 | 30-6 | .833 | | Mortgage Matchup Center · Phoenix, AZ |
| 37 | Mon Jan 5 | vs Hornets | L97-124 | 30-7 | .811 | | Paycom Center · Oklahoma City, OK |
| 38 | Wed Jan 7 | vs Jazz | W129-125 (OT) | 31-7 | .816 | | Paycom Center · Oklahoma City, OK |
| 39 | Fri Jan 9 | at Grizzlies | W117-116 | 32-7 | .821 | NBA TV | FedExForum · Memphis, TN |
| 40 | Sun Jan 11 | vs Heat | W124-112 | 33-7 | .825 | | Paycom Center · Oklahoma City, OK |
| 41 | Tue Jan 13 | vs Spurs | W119-98 | 34-7 | .829 | Peacock | Paycom Center · Oklahoma City, OK |
| 42 | Thu Jan 15 | at Rockets | W111-91 | 35-7 | .833 | Amazon | Toyota Center · Houston, TX |
| 43 | Sat Jan 17 | at Heat | L120-122 | 35-8 | .814 | | Kaseya Center · Miami, FL |
| 44 | Mon Jan 19 | at Cavaliers | W136-104 | 36-8 | .818 | Peacock | Rocket Mortgage FieldHouse · Cleveland, OH |
| 45 | Wed Jan 21 | at Bucks | W122-102 | 37-8 | .822 | ESPN | Fiserv Forum · Milwaukee, WI |
| 46 | Fri Jan 23 | vs Pacers | L114-117 | 37-9 | .804 | | Paycom Center · Oklahoma City, OK |
| 47 | Sun Jan 25 | vs Raptors | L101-103 | 37-10 | .787 | | Paycom Center · Oklahoma City, OK |
| 48 | Tue Jan 27 | vs Pelicans | W104-95 | 38-10 | .792 | | Paycom Center · Oklahoma City, OK |
| 49 | Thu Jan 29 | at T-wolves | L111-123 | 38-11 | .776 | Amazon | Target Center · Minneapolis, MN |
| 50 | Sun Feb 1 | at Nuggets | W121-111 | 39-11 | .780 | Peacock | Ball Arena · Denver, CO |
| 51 | Tue Feb 3 | vs Magic | W128-92 | 40-11 | .784 | | Paycom Center · Oklahoma City, OK |
| 52 | Wed Feb 4 | at Spurs | L106-116 | 40-12 | .769 | ESPN | AT&T Center · San Antonio, TX |
| 53 | Sat Feb 7 | vs Rockets | L106-112 | 40-13 | .755 | ABC | Paycom Center · Oklahoma City, OK |
| 54 | Mon Feb 9 | at Lakers | W119-110 | 41-13 | .759 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 55 | Wed Feb 11 | at Suns | W136-109 | 42-13 | .764 | | Mortgage Matchup Center · Phoenix, AZ |
| 56 | Thu Feb 12 | vs Bucks | L93-110 | 42-14 | .750 | Amazon | Paycom Center · Oklahoma City, OK |
| --all-star break-- |
| 57 | Fri Feb 20 | vs Nets | W105-86 | 43-14 | .754 | | Paycom Center · Oklahoma City, OK |
| 58 | Sun Feb 22 | vs Cavaliers | W121-113 | 44-14 | .759 | ABC | Paycom Center · Oklahoma City, OK |
| 59 | Tue Feb 24 | at Raptors | W116-107 | 45-14 | .763 | | Scotiabank Arena · Toronto, ON |
| 60 | Wed Feb 25 | at Pistons | L116-124 | 45-15 | .750 | ESPN | Little Caesars Arena · Detroit, MI |
| 61 | Fri Feb 27 | vs Nuggets | W127-121 (OT) | 46-15 | .754 | ESPN | Paycom Center · Oklahoma City, OK |
| 62 | Sun Mar 1 | at Mavericks | LIVE0-0 | 46-15 | .754 | | American Airlines Center · Dallas, TX |