| 1 | Sun Sep 13 | at Texans | 1:00 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| 2 | Thu Sep 17 | vsLions | 8:15 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 3 | Sun Sep 27 | vsChargers | 1:00 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 4 | Sun Oct 4 | vsPatriots | 1:00 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 5 | Mon Oct 12 | atRams | 8:15 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 18 | atRaiders | 4:25 PM | 0-0 | .000 | Allegiant Stadium · Las Vegas, NV |
| --bye week-- |
| 8 | Sun Nov 1 | vsRavens | 1:00 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 9 | Mon Nov 9 | atVikings | 8:15 PM | 0-0 | .000 | U.S. Bank Stadium · Minneapolis, MN |
| 10 | Sun Nov 15 | atJets | 1:00 PM | 0-0 | .000 | MetLife Stadium · East Rutherford, NJ |
| 11 | Sun Nov 22 | vsDolphins | 1:00 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 12 | Thu Nov 26 | vsChiefs | 8:20 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 13 | Sun Dec 6 | atPatriots | 4:25 PM | 0-0 | .000 | Gillette Stadium · Foxborough, MA |
| 14 | Sun Dec 13 | atPackers | 8:20 PM | 0-0 | .000 | Lambeau Field · Green Bay, WI |
| 15 | Sat Dec 19 | vsBears | 8:20 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 16 | Fri Dec 25 | atBroncos | 4:30 PM | 0-0 | .000 | Empower Field at Mile High · Denver, CO |
| 17 | Sun Jan 3 | atDolphins | 1:00 PM | 0-0 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 18 | TBD | vsJets | TBD | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
