| 1 | Mon Sep 14 | vs Titans | L14-16 | 0-1 | .000 | Empower Field at Mile High · Denver, CO |
| 2 | Sun Sep 20 | atSteelers | L21-26 | 0-2 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 27 | vsBuccaneers | L10-28 | 0-3 | .000 | Empower Field at Mile High · Denver, CO |
| 4 | Thu Oct 1 | atJets | W37-28 | 1-3 | .250 | MetLife Stadium · East Rutherford, NJ |
| --bye week-- |
| 6 | Sun Oct 18 | atPatriots | W18-12 | 2-3 | .400 | Gillette Stadium · Foxborough, MA |
| 7 | Sun Oct 25 | vsChiefs | L16-43 | 2-4 | .333 | Empower Field at Mile High · Denver, CO |
| 8 | Sun Nov 1 | vsChargers | W31-30 | 3-4 | .429 | Empower Field at Mile High · Denver, CO |
| 9 | Sun Nov 8 | atFalcons | L27-34 | 3-5 | .375 | Mercedes-Benz Stadium · Atlanta, GA |
| 10 | Sun Nov 15 | atRaiders | L12-37 | 3-6 | .333 | Allegiant Stadium · Las Vegas, NV |
| 11 | Sun Nov 22 | vsDolphins | W20-13 | 4-6 | .400 | Empower Field at Mile High · Denver, CO |
| 12 | Sun Nov 29 | vsSaints | L3-31 | 4-7 | .364 | Empower Field at Mile High · Denver, CO |
| 13 | Sun Dec 6 | atChiefs | L16-22 | 4-8 | .333 | Arrowhead Stadium · Kansas City, MO |
| 14 | Sun Dec 13 | atPanthers | W32-27 | 5-8 | .385 | Bank of America Stadium · Charlotte, NC |
| 15 | Sat Dec 19 | vsBills | L19-48 | 5-9 | .357 | Empower Field at Mile High · Denver, CO |
| 16 | Sun Dec 27 | atChargers | L16-19 | 5-10 | .333 | SoFi Stadium · Inglewood, CA |
| 17 | Sun Jan 3 | vsRaiders | L31-32 | 5-11 | .313 | Empower Field at Mile High · Denver, CO |
