| 5 | Sun Oct 5 | at Eagles | 1:00 PM | 4-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 6 | Sun Oct 12 | atJets | 9:30 AM | 0-4 | .000 | Tottenham Hotspur Stadium · London, England |
| 7 | Sun Oct 19 | vsGiants | 4:05 PM | 1-3 | .250 | Empower Field at Mile High · Denver, CO |
| 8 | Sun Oct 26 | vsCowboys | 4:25 PM | 1-2-1 | .375 | Empower Field at Mile High · Denver, CO |
| 9 | Sun Nov 2 | atTexans | 1:00 PM | 1-3 | .250 | NRG Stadium · Houston, TX |
| 10 | Thu Nov 6 | vsRaiders | 8:15 PM | 1-3 | .250 | Empower Field at Mile High · Denver, CO |
| 11 | Sun Nov 16 | vsChiefs | 4:25 PM | 2-2 | .500 | Empower Field at Mile High · Denver, CO |
| --bye week-- |
| 13 | Sun Nov 30 | atCommanders | 8:20 PM | 2-2 | .500 | FedEx Field · North Englewood, MD |
| 14 | Sun Dec 7 | atRaiders | 4:05 PM | 1-3 | .250 | Allegiant Stadium · Las Vegas, NV |
| 15 | Sun Dec 14 | vsPackers | 4:25 PM | 2-1-1 | .625 | Empower Field at Mile High · Denver, CO |
| 16 | Sun Dec 21 | vsJaguars | 4:05 PM | 3-1 | .750 | Empower Field at Mile High · Denver, CO |
| 17 | Thu Dec 25 | atChiefs | 8:15 PM | 2-2 | .500 | Arrowhead Stadium · Kansas City, MO |
| 18 | TBD | vsChargers | TBD | 3-1 | .750 | Empower Field at Mile High · Denver, CO |
