| 1 | Sun Sep 12 | at Giants | W27-13 | 1-0 | 1.000 | MetLife Stadium · East Rutherford, NJ |
| 2 | Sun Sep 19 | at Jaguars | W23-13 | 2-0 | 1.000 | TIAA Bank Field · Jacksonville, FL |
| 3 | Sun Sep 26 | vs Jets | W26-0 | 3-0 | 1.000 | Empower Field at Mile High · Denver, CO |
| 4 | Sun Oct 3 | vs Ravens | L7-23 | 3-1 | .750 | Empower Field at Mile High · Denver, CO |
| 5 | Sun Oct 10 | at Steelers | L19-27 | 3-2 | .600 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sun Oct 17 | vs Raiders | L24-34 | 3-3 | .500 | Empower Field at Mile High · Denver, CO |
| 7 | Thu Oct 21 | at Browns | L14-17 | 3-4 | .429 | FirstEnergy Stadium · Cleveland, OH |
| 8 | Sun Oct 31 | vs Commanders | W17-10 | 4-4 | .500 | Empower Field at Mile High · Denver, CO |
| 9 | Sun Nov 7 | at Cowboys | W30-16 | 5-4 | .556 | AT&T Stadium · Arlington, TX |
| 10 | Sun Nov 14 | vs Eagles | L13-30 | 5-5 | .500 | Empower Field at Mile High · Denver, CO |
| 11 | -- BYE WEEK -- |
| 12 | Sun Nov 28 | vs Chargers | W28-13 | 6-5 | .545 | Empower Field at Mile High · Denver, CO |
| 13 | Sun Dec 5 | at Chiefs | L9-22 | 6-6 | .500 | Arrowhead Stadium · Kansas City, MO |
| 14 | Sun Dec 12 | vs Lions | W38-10 | 7-6 | .538 | Empower Field at Mile High · Denver, CO |
| 15 | Sun Dec 19 | vs Bengals | L10-15 | 7-7 | .500 | Empower Field at Mile High · Denver, CO |
| 16 | Sun Dec 26 | atRaiders | L13-17 | 7-8 | .467 | Allegiant Stadium · Las Vegas, NV |
| 17 | Sun Jan 2 | atChargers | L13-34 | 7-9 | .438 | SoFi Stadium · Inglewood, CA |
| 18 | Sat Jan 8 | vsChiefs | L24-28 | 7-10 | .412 | Empower Field at Mile High · Denver, CO |
