| 1 | Mon Sep 12 | at Seahawks | L16-17 | 0-1 | .000 | Lumen Field · Seattle, WA |
| 2 | Sun Sep 18 | vsTexans | W16-9 | 1-1 | .500 | Empower Field at Mile High · Denver, CO |
| 3 | Sun Sep 25 | vs49ers | W11-10 | 2-1 | .667 | Empower Field at Mile High · Denver, CO |
| 4 | Sun Oct 2 | atRaiders | L23-32 | 2-2 | .500 | Allegiant Stadium · Las Vegas, NV |
| 5 | Thu Oct 6 | vsColts | L9-12 (OT) | 2-3 | .400 | Empower Field at Mile High · Denver, CO |
| 6 | Mon Oct 17 | atChargers | L16-19 (OT) | 2-4 | .333 | SoFi Stadium · Inglewood, CA |
| 7 | Sun Oct 23 | vsJets | L9-16 | 2-5 | .286 | Empower Field at Mile High · Denver, CO |
| 8 | Sun Oct 30 | atJaguars | W21-17 | 3-5 | .375 | Wembley Stadium · London, England |
| --bye week-- |
| 10 | Sun Nov 13 | atTitans | L10-17 | 3-6 | .333 | Nissan Stadium · Nashville, TN |
| 11 | Sun Nov 20 | vsRaiders | L16-22 (OT) | 3-7 | .300 | Empower Field at Mile High · Denver, CO |
| 12 | Sun Nov 27 | atPanthers | L10-23 | 3-8 | .273 | Bank of America Stadium · Charlotte, NC |
| 13 | Sun Dec 4 | atRavens | L9-10 | 3-9 | .250 | M&T Bank Stadium · Baltimore, MD |
| 14 | Sun Dec 11 | vsChiefs | L28-34 | 3-10 | .231 | Empower Field at Mile High · Denver, CO |
| 15 | Sun Dec 18 | vsCardinals | W24-15 | 4-10 | .286 | Empower Field at Mile High · Denver, CO |
| 16 | Sun Dec 25 | atRams | L14-51 | 4-11 | .267 | SoFi Stadium · Inglewood, CA |
| 17 | Sun Jan 1 | atChiefs | L24-27 | 4-12 | .250 | Arrowhead Stadium · Kansas City, MO |
| 18 | Sun Jan 8 | vsChargers | W31-28 | 5-12 | .294 | Empower Field at Mile High · Denver, CO |
