| 1 | Sun Sep 8 | at Seahawks | L20-26 | 0-1 | .000 | Lumen Field · Seattle, WA |
| 2 | Sun Sep 15 | vsSteelers | L6-13 | 0-2 | .000 | Empower Field at Mile High · Denver, CO |
| 3 | Sun Sep 22 | atBuccaneers | W26-7 | 1-2 | .333 | Raymond James Stadium · Tampa, FL |
| 4 | Sun Sep 29 | atJets | W10-9 | 2-2 | .500 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 6 | vsRaiders | W34-18 | 3-2 | .600 | Empower Field at Mile High · Denver, CO |
| 6 | Sun Oct 13 | vsChargers | L16-23 | 3-3 | .500 | Empower Field at Mile High · Denver, CO |
| 7 | Thu Oct 17 | atSaints | W33-10 | 4-3 | .571 | Caesars Superdome · New Orleans, LA |
| 8 | Sun Oct 27 | vsPanthers | W28-14 | 5-3 | .625 | Empower Field at Mile High · Denver, CO |
| 9 | Sun Nov 3 | atRavens | L10-41 | 5-4 | .556 | M&T Bank Stadium · Baltimore, MD |
| 10 | Sun Nov 10 | atChiefs | L14-16 | 5-5 | .500 | Arrowhead Stadium · Kansas City, MO |
| 11 | Sun Nov 17 | vsFalcons | W38-6 | 6-5 | .545 | Empower Field at Mile High · Denver, CO |
| 12 | Sun Nov 24 | atRaiders | W29-19 | 7-5 | .583 | Allegiant Stadium · Las Vegas, NV |
| 13 | Mon Dec 2 | vsBrowns | W41-32 | 8-5 | .615 | Empower Field at Mile High · Denver, CO |
| --bye week-- |
| 15 | Sun Dec 15 | vsColts | W31-13 | 9-5 | .643 | Empower Field at Mile High · Denver, CO |
| 16 | Thu Dec 19 | atChargers | L27-34 | 9-6 | .600 | SoFi Stadium · Inglewood, CA |
| 17 | Sat Dec 28 | atBengals | L24-30 (OT) | 9-7 | .563 | Paycor Stadium · Cincinnati, OH |
| 18 | Sun Jan 5 | vsChiefs | W38-0 | 10-7 | .588 | Empower Field at Mile High · Denver, CO |
| WC | Sun Jan 12 | atBills | L7-31 | 10-7 | .588 | Highmark Stadium · Orchard Park, NY |
