| 1 | Sun Sep 10 | vs Raiders | L16-17 | 0-1 | .000 | Empower Field at Mile High · Denver, CO |
| 2 | Sun Sep 17 | vsCommanders | L33-35 | 0-2 | .000 | Empower Field at Mile High · Denver, CO |
| 3 | Sun Sep 24 | atDolphins | L20-70 | 0-3 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 4 | Sun Oct 1 | atBears | W31-28 | 1-3 | .250 | Soldier Field · Chicago, IL |
| 5 | Sun Oct 8 | vsJets | L21-31 | 1-4 | .200 | Empower Field at Mile High · Denver, CO |
| 6 | Thu Oct 12 | atChiefs | L8-19 | 1-5 | .167 | Arrowhead Stadium · Kansas City, MO |
| 7 | Sun Oct 22 | vsPackers | W19-17 | 2-5 | .286 | Empower Field at Mile High · Denver, CO |
| 8 | Sun Oct 29 | vsChiefs | W24-9 | 3-5 | .375 | Empower Field at Mile High · Denver, CO |
| --bye week-- |
| 10 | Mon Nov 13 | atBills | W24-22 | 4-5 | .444 | Highmark Stadium · Orchard Park, NY |
| 11 | Sun Nov 19 | vsVikings | W21-20 | 5-5 | .500 | Empower Field at Mile High · Denver, CO |
| 12 | Sun Nov 26 | vsBrowns | W29-12 | 6-5 | .545 | Empower Field at Mile High · Denver, CO |
| 13 | Sun Dec 3 | atTexans | L17-22 | 6-6 | .500 | NRG Stadium · Houston, TX |
| 14 | Sun Dec 10 | atChargers | W24-7 | 7-6 | .538 | SoFi Stadium · Inglewood, CA |
| 15 | Sat Dec 16 | atLions | L17-42 | 7-7 | .500 | Ford Field · Detroit, MI |
| 16 | Sun Dec 24 | vsPatriots | L23-26 | 7-8 | .467 | Empower Field at Mile High · Denver, CO |
| 17 | Sun Dec 31 | vsChargers | W16-9 | 8-8 | .500 | Empower Field at Mile High · Denver, CO |
| 18 | Sun Jan 7 | atRaiders | L14-27 | 8-9 | .471 | Allegiant Stadium · Las Vegas, NV |
