| 1 | Sun Sep 13 | at Vikings | W43-34 | 1-0 | 1.000 | U.S. Bank Stadium · Minneapolis, MN |
| 2 | Sun Sep 20 | vsLions | W42-21 | 2-0 | 1.000 | Lambeau Field · Green Bay, WI |
| 3 | Sun Sep 27 | atSaints | W37-30 | 3-0 | 1.000 | Caesars Superdome · New Orleans, LA |
| 4 | Mon Oct 5 | vsFalcons | W30-16 | 4-0 | 1.000 | Lambeau Field · Green Bay, WI |
| --bye week-- |
| 6 | Sun Oct 18 | atBuccaneers | L10-38 | 4-1 | .800 | Raymond James Stadium · Tampa, FL |
| 7 | Sun Oct 25 | atTexans | W35-20 | 5-1 | .833 | NRG Stadium · Houston, TX |
| 8 | Sun Nov 1 | vsVikings | L22-28 | 5-2 | .714 | Lambeau Field · Green Bay, WI |
| 9 | Thu Nov 5 | at49ers | W34-17 | 6-2 | .750 | Levi's® Stadium · Santa Clara, CA |
| 10 | Sun Nov 15 | vsJaguars | W24-20 | 7-2 | .778 | Lambeau Field · Green Bay, WI |
| 11 | Sun Nov 22 | atColts | L31-34 (OT) | 7-3 | .700 | Lucas Oil Stadium · Indianapolis, IN |
| 12 | Sun Nov 29 | vsBears | W41-25 | 8-3 | .727 | Lambeau Field · Green Bay, WI |
| 13 | Sun Dec 6 | vsEagles | W30-16 | 9-3 | .750 | Lambeau Field · Green Bay, WI |
| 14 | Sun Dec 13 | atLions | W31-24 | 10-3 | .769 | Ford Field · Detroit, MI |
| 15 | Sat Dec 19 | vsPanthers | W24-16 | 11-3 | .786 | Lambeau Field · Green Bay, WI |
| 16 | Sun Dec 27 | vsTitans | W40-14 | 12-3 | .800 | Lambeau Field · Green Bay, WI |
| 17 | Sun Jan 3 | atBears | W35-16 | 13-3 | .813 | Soldier Field · Chicago, IL |
| DIV | Sat Jan 16 | vsRams | W32-18 | 13-3 | .813 | Lambeau Field · Green Bay, WI |
| CONF | Sun Jan 24 | vsBuccaneers | L26-31 | 13-3 | .813 | Lambeau Field · Green Bay, WI |
