| 1 | Sun Sep 13 | vs Bills | 1:00 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| 2 | Sun Sep 20 | vsBengals | 1:00 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| 3 | Sun Sep 27 | atColts | 1:00 PM | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
| 4 | Sun Oct 4 | vsCowboys | 1:00 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 11 | atTitans | 1:00 PM | 0-0 | .000 | Nissan Stadium · Nashville, TN |
| 6 | Sun Oct 18 | atJaguars | 9:30 AM | 0-0 | .000 | Wembley Stadium · London, England |
| 7 | Sun Oct 25 | vsGiants | 1:00 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| --bye week-- |
| 9 | Sun Nov 8 | atChargers | 4:05 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 10 | Sun Nov 15 | atBrowns | 1:00 PM | 0-0 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 11 | Thu Nov 19 | vsColts | 8:15 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| 12 | Sun Nov 29 | vsRavens | 1:00 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| 13 | Sun Dec 6 | atSteelers | 8:20 PM | 0-0 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Sun Dec 13 | atCommanders | 1:00 PM | 0-0 | .000 | FedEx Field · North Englewood, MD |
| 15 | Sun Dec 20 | vsJaguars | 1:00 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| 16 | Thu Dec 24 | atEagles | 8:15 PM | 0-0 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 17 | Mon Jan 4 | atPackers | 8:15 PM | 0-0 | .000 | Lambeau Field · Green Bay, WI |
| 18 | TBD | vsTitans | TBD | 0-0 | .000 | NRG Stadium · Houston, TX |
