| 1 | Mon Sep 9 | vs Broncos | W24-16 | 1-0 | 1.000 | Allegiant Stadium · Las Vegas, NV |
| 2 | Sun Sep 15 | vsChiefs | L10-28 | 1-1 | .500 | Allegiant Stadium · Las Vegas, NV |
| 3 | Sun Sep 22 | atVikings | L14-34 | 1-2 | .333 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Sep 29 | atColts | W31-24 | 2-2 | .500 | Lucas Oil Stadium · Indianapolis, IN |
| 5 | Sun Oct 6 | vsBears | W24-21 | 3-2 | .600 | Tottenham Hotspur Stadium · London, England |
| --bye week-- |
| 7 | Sun Oct 20 | atPackers | L24-42 | 3-3 | .500 | Lambeau Field · Green Bay, WI |
| 8 | Sun Oct 27 | atTexans | L24-27 | 3-4 | .429 | NRG Stadium · Houston, TX |
| 9 | Sun Nov 3 | vsLions | W31-24 | 4-4 | .500 | Allegiant Stadium · Las Vegas, NV |
| 10 | Thu Nov 7 | vsChargers | W26-24 | 5-4 | .556 | Allegiant Stadium · Las Vegas, NV |
| 11 | Sun Nov 17 | vsBengals | W17-10 | 6-4 | .600 | Allegiant Stadium · Las Vegas, NV |
| 12 | Sun Nov 24 | atJets | L3-34 | 6-5 | .545 | MetLife Stadium · East Rutherford, NJ |
| 13 | Sun Dec 1 | atChiefs | L9-40 | 6-6 | .500 | Arrowhead Stadium · Kansas City, MO |
| 14 | Sun Dec 8 | vsTitans | L21-42 | 6-7 | .462 | Allegiant Stadium · Las Vegas, NV |
| 15 | Sun Dec 15 | vsJaguars | L16-20 | 6-8 | .429 | Allegiant Stadium · Las Vegas, NV |
| 16 | Sun Dec 22 | atChargers | W24-17 | 7-8 | .467 | SoFi Stadium · Inglewood, CA |
| 17 | Sun Dec 29 | atBroncos | L15-16 | 7-9 | .438 | Empower Field at Mile High · Denver, CO |
