| 1 | Sun Sep 8 | at Chargers | L10-22 | - | 0-1 | .000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 15 | atRavens | W26-23 | - | 1-1 | .500 | M&T Bank Stadium · Baltimore, MD |
| 3 | Sun Sep 22 | vsPanthers | L22-36 | - | 1-2 | .333 | Allegiant Stadium · Las Vegas, NV |
| 4 | Sun Sep 29 | vsBrowns | W20-16 | - | 2-2 | .500 | Allegiant Stadium · Las Vegas, NV |
| 5 | Sun Oct 6 | atBroncos | L18-34 | - | 2-3 | .400 | Empower Field at Mile High · Denver, CO |
| 6 | Sun Oct 13 | vsSteelers | L13-32 | - | 2-4 | .333 | Allegiant Stadium · Las Vegas, NV |
| 7 | Sun Oct 20 | atRams | L15-20 | - | 2-5 | .286 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Oct 27 | vsChiefs | L20-27 | - | 2-6 | .250 | Allegiant Stadium · Las Vegas, NV |
| 9 | Sun Nov 3 | atBengals | L24-41 | - | 2-7 | .222 | Paycor Stadium · Cincinnati, OH |
| --bye week-- |
| 11 | Sun Nov 17 | atDolphins | L19-34 | - | 2-8 | .200 | Hard Rock Stadium · Miami Gardens, FL |
| 12 | Sun Nov 24 | vsBroncos | L19-29 | - | 2-9 | .182 | Allegiant Stadium · Las Vegas, NV |
| 13 | Fri Nov 29 | atChiefs | L17-19 | - | 2-10 | .167 | Arrowhead Stadium · Kansas City, MO |
| 14 | Sun Dec 8 | atBuccaneers | L13-28 | - | 2-11 | .154 | Raymond James Stadium · Tampa, FL |
| 15 | Mon Dec 16 | vsFalcons | L9-15 | - | 2-12 | .143 | Allegiant Stadium · Las Vegas, NV |
| 16 | Sun Dec 22 | vsJaguars | W19-14 | - | 3-12 | .200 | Allegiant Stadium · Las Vegas, NV |
| 17 | Sun Dec 29 | atSaints | W25-10 | - | 4-12 | .250 | Caesars Superdome · New Orleans, LA |
| 18 | Sun Jan 5 | vsChargers | L20-34 | - | 4-13 | .235 | Allegiant Stadium · Las Vegas, NV |
