| 1 | Mon Sep 13 | vs Ravens | W33-27 (OT) | - | 1-0 | 1.000 | Allegiant Stadium · Las Vegas, NV |
| 2 | Sun Sep 19 | atSteelers | W26-17 | - | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 26 | vsDolphins | W31-28 (OT) | - | 3-0 | 1.000 | Allegiant Stadium · Las Vegas, NV |
| 4 | Mon Oct 4 | atChargers | L14-28 | - | 3-1 | .750 | SoFi Stadium · Inglewood, CA |
| 5 | Sun Oct 10 | vsBears | L9-20 | - | 3-2 | .600 | Allegiant Stadium · Las Vegas, NV |
| 6 | Sun Oct 17 | atBroncos | W34-24 | - | 4-2 | .667 | Empower Field at Mile High · Denver, CO |
| 7 | Sun Oct 24 | vsEagles | W33-22 | - | 5-2 | .714 | Allegiant Stadium · Las Vegas, NV |
| --bye week-- |
| 9 | Sun Nov 7 | atGiants | L16-23 | - | 5-3 | .625 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 14 | vsChiefs | L14-41 | - | 5-4 | .556 | Allegiant Stadium · Las Vegas, NV |
| 11 | Sun Nov 21 | vsBengals | L13-32 | - | 5-5 | .500 | Allegiant Stadium · Las Vegas, NV |
| 12 | Thu Nov 25 | atCowboys | W36-33 (OT) | - | 6-5 | .545 | AT&T Stadium · Arlington, TX |
| 13 | Sun Dec 5 | vsCommanders | L15-17 | - | 6-6 | .500 | Allegiant Stadium · Las Vegas, NV |
| 14 | Sun Dec 12 | atChiefs | L9-48 | - | 6-7 | .462 | Arrowhead Stadium · Kansas City, MO |
| 15 | Mon Dec 20 | atBrowns | W16-14 | - | 7-7 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 16 | Sun Dec 26 | vsBroncos | W17-13 | - | 8-7 | .533 | Allegiant Stadium · Las Vegas, NV |
| 17 | Sun Jan 2 | atColts | W23-20 | - | 9-7 | .563 | Lucas Oil Stadium · Indianapolis, IN |
| 18 | Sun Jan 9 | vsChargers | W35-32 (OT) | - | 10-7 | .588 | Allegiant Stadium · Las Vegas, NV |
| WC | Sat Jan 15 | atBengals | L19-26 | - | 10-7 | .588 | Paycor Stadium · Cincinnati, OH |
