| 1 | Sun Sep 11 | at Chargers | L19-24 | - | 0-1 | .000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 18 | vsCardinals | L23-29 (OT) | - | 0-2 | .000 | Allegiant Stadium · Las Vegas, NV |
| 3 | Sun Sep 25 | atTitans | L22-24 | - | 0-3 | .000 | Nissan Stadium · Nashville, TN |
| 4 | Sun Oct 2 | vsBroncos | W32-23 | - | 1-3 | .250 | Allegiant Stadium · Las Vegas, NV |
| 5 | Mon Oct 10 | atChiefs | L29-30 | - | 1-4 | .200 | Arrowhead Stadium · Kansas City, MO |
| --bye week-- |
| 7 | Sun Oct 23 | vsTexans | W38-20 | - | 2-4 | .333 | Allegiant Stadium · Las Vegas, NV |
| 8 | Sun Oct 30 | atSaints | L0-24 | - | 2-5 | .286 | Caesars Superdome · New Orleans, LA |
| 9 | Sun Nov 6 | atJaguars | L20-27 | - | 2-6 | .250 | TIAA Bank Field · Jacksonville, FL |
| 10 | Sun Nov 13 | vsColts | L20-25 | - | 2-7 | .222 | Allegiant Stadium · Las Vegas, NV |
| 11 | Sun Nov 20 | atBroncos | W22-16 (OT) | - | 3-7 | .300 | Empower Field at Mile High · Denver, CO |
| 12 | Sun Nov 27 | atSeahawks | W40-34 (OT) | - | 4-7 | .364 | Lumen Field · Seattle, WA |
| 13 | Sun Dec 4 | vsChargers | W27-20 | - | 5-7 | .417 | Allegiant Stadium · Las Vegas, NV |
| 14 | Thu Dec 8 | atRams | L16-17 | - | 5-8 | .385 | SoFi Stadium · Inglewood, CA |
| 15 | Sun Dec 18 | vsPatriots | W30-24 | - | 6-8 | .429 | Allegiant Stadium · Las Vegas, NV |
| 16 | Sat Dec 24 | atSteelers | L10-13 | - | 6-9 | .400 | Acrisure Stadium · Pittsburgh, PA |
| 17 | Sun Jan 1 | vs49ers | L34-37 (OT) | - | 6-10 | .375 | Allegiant Stadium · Las Vegas, NV |
