| 1 | Sun Sep 10 | at Broncos | W17-16 | - | 1-0 | 1.000 | Empower Field at Mile High · Denver, CO |
| 2 | Sun Sep 17 | atBills | L10-38 | - | 1-1 | .500 | Highmark Stadium · Orchard Park, NY |
| 3 | Sun Sep 24 | vsSteelers | L18-23 | - | 1-2 | .333 | Allegiant Stadium · Las Vegas, NV |
| 4 | Sun Oct 1 | atChargers | L17-24 | - | 1-3 | .250 | SoFi Stadium · Inglewood, CA |
| 5 | Mon Oct 9 | vsPackers | W17-13 | - | 2-3 | .400 | Allegiant Stadium · Las Vegas, NV |
| 6 | Sun Oct 15 | vsPatriots | W21-17 | - | 3-3 | .500 | Allegiant Stadium · Las Vegas, NV |
| 7 | Sun Oct 22 | atBears | L12-30 | - | 3-4 | .429 | Soldier Field · Chicago, IL |
| 8 | Mon Oct 30 | atLions | L14-26 | - | 3-5 | .375 | Ford Field · Detroit, MI |
| 9 | Sun Nov 5 | vsGiants | W30-6 | - | 4-5 | .444 | Allegiant Stadium · Las Vegas, NV |
| 10 | Sun Nov 12 | vsJets | W16-12 | - | 5-5 | .500 | Allegiant Stadium · Las Vegas, NV |
| 11 | Sun Nov 19 | atDolphins | L13-20 | - | 5-6 | .455 | Hard Rock Stadium · Miami Gardens, FL |
| 12 | Sun Nov 26 | vsChiefs | L17-31 | - | 5-7 | .417 | Allegiant Stadium · Las Vegas, NV |
| --bye week-- |
| 14 | Sun Dec 10 | vsVikings | L0-3 | - | 5-8 | .385 | Allegiant Stadium · Las Vegas, NV |
| 15 | Thu Dec 14 | vsChargers | W63-21 | - | 6-8 | .429 | Allegiant Stadium · Las Vegas, NV |
| 16 | Mon Dec 25 | atChiefs | W20-14 | - | 7-8 | .467 | Arrowhead Stadium · Kansas City, MO |
| 17 | Sun Dec 31 | atColts | L20-23 | - | 7-9 | .438 | Lucas Oil Stadium · Indianapolis, IN |
| 18 | Sun Jan 7 | vsBroncos | W27-14 | - | 8-9 | .471 | Allegiant Stadium · Las Vegas, NV |
