| 4 | Sun Sep 28 | vs Bears | 4:25 PM | 1-2 | .333 | Allegiant Stadium · Las Vegas, NV |
| 5 | Sun Oct 5 | atColts | 1:00 PM | 3-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 6 | Sun Oct 12 | vsTitans | 4:05 PM | 0-3 | .000 | Allegiant Stadium · Las Vegas, NV |
| 7 | Sun Oct 19 | atChiefs | 1:00 PM | 1-2 | .333 | Arrowhead Stadium · Kansas City, MO |
| --bye week-- |
| 9 | Sun Nov 2 | vsJaguars | 4:05 PM | 2-1 | .667 | Allegiant Stadium · Las Vegas, NV |
| 10 | Thu Nov 6 | atBroncos | 8:15 PM | 1-2 | .333 | Empower Field at Mile High · Denver, CO |
| 11 | Mon Nov 17 | vsCowboys | 8:15 PM | 1-2 | .333 | Allegiant Stadium · Las Vegas, NV |
| 12 | Sun Nov 23 | vsBrowns | 4:05 PM | 1-2 | .333 | Allegiant Stadium · Las Vegas, NV |
| 13 | Sun Nov 30 | atChargers | 4:25 PM | 3-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 14 | Sun Dec 7 | vsBroncos | 4:05 PM | 1-2 | .333 | Allegiant Stadium · Las Vegas, NV |
| 15 | Sun Dec 14 | atEagles | 1:00 PM | 3-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 16 | Sun Dec 21 | atTexans | 4:25 PM | 0-3 | .000 | NRG Stadium · Houston, TX |
| 17 | TBD | vsGiants | TBD | 0-3 | .000 | Allegiant Stadium · Las Vegas, NV |
| 18 | TBD | vsChiefs | TBD | 1-2 | .333 | Allegiant Stadium · Las Vegas, NV |
