| 1 | Sun Sep 8 | at Cowboys | L17-35 | 0-1 | .000 | AT&T Stadium · Arlington, TX |
| 2 | Sun Sep 15 | vsBills | L14-28 | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 3 | Sun Sep 22 | atBuccaneers | W32-31 | 1-2 | .333 | Raymond James Stadium · Tampa, FL |
| 4 | Sun Sep 29 | vsCommanders | W24-3 | 2-2 | .500 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 6 | vsVikings | L10-28 | 2-3 | .400 | MetLife Stadium · East Rutherford, NJ |
| 6 | Thu Oct 10 | atPatriots | L14-35 | 2-4 | .333 | Gillette Stadium · Foxborough, MA |
| 7 | Sun Oct 20 | vsCardinals | L21-27 | 2-5 | .286 | MetLife Stadium · East Rutherford, NJ |
| 8 | Sun Oct 27 | atLions | L26-31 | 2-6 | .250 | Ford Field · Detroit, MI |
| 9 | Mon Nov 4 | vsCowboys | L18-37 | 2-7 | .222 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 10 | atJets | L27-34 | 2-8 | .200 | MetLife Stadium · East Rutherford, NJ |
| --bye week-- |
| 12 | Sun Nov 24 | atBears | L14-19 | 2-9 | .182 | Soldier Field · Chicago, IL |
| 13 | Sun Dec 1 | vsPackers | L13-31 | 2-10 | .167 | MetLife Stadium · East Rutherford, NJ |
| 14 | Mon Dec 9 | atEagles | L17-23 (OT) | 2-11 | .154 | Lincoln Financial Field · Philadelphia, PA |
| 15 | Sun Dec 15 | vsDolphins | W36-20 | 3-11 | .214 | MetLife Stadium · East Rutherford, NJ |
| 16 | Sun Dec 22 | atCommanders | W41-35 (OT) | 4-11 | .267 | FedEx Field · North Englewood, MD |
| 17 | Sun Dec 29 | vsEagles | L17-34 | 4-12 | .250 | MetLife Stadium · East Rutherford, NJ |
