| 1 | Sun Sep 10 | vs Cowboys | L0-40 | 0-1 | .000 | MetLife Stadium · East Rutherford, NJ |
| 2 | Sun Sep 17 | atCardinals | W31-28 | 1-1 | .500 | State Farm Stadium · Glendale, AZ |
| 3 | Thu Sep 21 | at49ers | L12-30 | 1-2 | .333 | Levi's® Stadium · Santa Clara, CA |
| 4 | Mon Oct 2 | vsSeahawks | L3-24 | 1-3 | .250 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 8 | atDolphins | L16-31 | 1-4 | .200 | Hard Rock Stadium · Miami Gardens, FL |
| 6 | Sun Oct 15 | atBills | L9-14 | 1-5 | .167 | Highmark Stadium · Orchard Park, NY |
| 7 | Sun Oct 22 | vsCommanders | W14-7 | 2-5 | .286 | MetLife Stadium · East Rutherford, NJ |
| 8 | Sun Oct 29 | vsJets | L10-13 (OT) | 2-6 | .250 | MetLife Stadium · East Rutherford, NJ |
| 9 | Sun Nov 5 | atRaiders | L6-30 | 2-7 | .222 | Allegiant Stadium · Las Vegas, NV |
| 10 | Sun Nov 12 | atCowboys | L17-49 | 2-8 | .200 | AT&T Stadium · Arlington, TX |
| 11 | Sun Nov 19 | atCommanders | W31-19 | 3-8 | .273 | FedEx Field · North Englewood, MD |
| 12 | Sun Nov 26 | vsPatriots | W10-7 | 4-8 | .333 | MetLife Stadium · East Rutherford, NJ |
| --bye week-- |
| 14 | Mon Dec 11 | vsPackers | W24-22 | 5-8 | .385 | MetLife Stadium · East Rutherford, NJ |
| 15 | Sun Dec 17 | atSaints | L6-24 | 5-9 | .357 | Caesars Superdome · New Orleans, LA |
| 16 | Mon Dec 25 | atEagles | L25-33 | 5-10 | .333 | Lincoln Financial Field · Philadelphia, PA |
| 17 | Sun Dec 31 | vsRams | L25-26 | 5-11 | .313 | MetLife Stadium · East Rutherford, NJ |
| 18 | Sun Jan 7 | vsEagles | W27-10 | 6-11 | .353 | MetLife Stadium · East Rutherford, NJ |
