| 5 | Sun Oct 5 | at Saints | 1:00 PM | 0-4 | .000 | Caesars Superdome · New Orleans, LA |
| 6 | Thu Oct 9 | vsEagles | 8:15 PM | 4-0 | 1.000 | MetLife Stadium · East Rutherford, NJ |
| 7 | Sun Oct 19 | atBroncos | 4:05 PM | 2-2 | .500 | Empower Field at Mile High · Denver, CO |
| 8 | Sun Oct 26 | atEagles | 1:00 PM | 4-0 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 9 | Sun Nov 2 | vs49ers | 1:00 PM | 3-1 | .750 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 9 | atBears | 1:00 PM | 2-2 | .500 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 16 | vsPackers | 1:00 PM | 2-1-1 | .625 | MetLife Stadium · East Rutherford, NJ |
| 12 | Sun Nov 23 | atLions | 1:00 PM | 3-1 | .750 | Ford Field · Detroit, MI |
| 13 | Mon Dec 1 | atPatriots | 8:15 PM | 2-2 | .500 | Gillette Stadium · Foxborough, MA |
| --bye week-- |
| 15 | Sun Dec 14 | vsCommanders | 1:00 PM | 2-2 | .500 | MetLife Stadium · East Rutherford, NJ |
| 16 | Sun Dec 21 | vsVikings | 1:00 PM | 2-2 | .500 | MetLife Stadium · East Rutherford, NJ |
| 17 | TBD | atRaiders | TBD | 1-3 | .250 | Allegiant Stadium · Las Vegas, NV |
| 18 | TBD | vsCowboys | TBD | 1-2-1 | .375 | MetLife Stadium · East Rutherford, NJ |
