| 1 | Wed Oct 23 | vs Bulls | W126-125 | 1-0 | 1.000 | Spectrum Center · Charlotte, NC |
| 2 | Fri Oct 25 | vs T-wolves | L99-121 | 1-1 | .500 | Spectrum Center · Charlotte, NC |
| 3 | Sun Oct 27 | at Lakers | L101-120 | 1-2 | .333 | Crypto.com Arena · Los Angeles, CA |
| 4 | Mon Oct 28 | at Clippers | L96-111 | 1-3 | .250 | Crypto.com Arena · Los Angeles, CA |
| 5 | Wed Oct 30 | at Kings | W118-111 | 2-3 | .400 | Golden 1 Center · Sacramento, CA |
| 6 | Sat Nov 2 | at Warriors | W93-87 | 3-3 | .500 | Chase Center · San Francisco, CA |
| 7 | Tue Nov 5 | vs Pacers | W122-120 (OT) | 4-3 | .571 | Spectrum Center · Charlotte, NC |
| 8 | Thu Nov 7 | vs Celtics | L87-108 | 4-4 | .500 | Spectrum Center · Charlotte, NC |
| 9 | Sat Nov 9 | vs Pelicans | L110-115 | 4-5 | .444 | Spectrum Center · Charlotte, NC |
| 10 | Sun Nov 10 | at 76ers | L106-114 | 4-6 | .400 | Wells Fargo Center · Philadelphia, PA |
| 11 | Wed Nov 13 | vs Grizzlies | L117-119 | 4-7 | .364 | Spectrum Center · Charlotte, NC |
| 12 | Fri Nov 15 | vs Pistons | W109-106 | 5-7 | .417 | Spectrum Center · Charlotte, NC |
| 13 | Sat Nov 16 | at Knicks | W103-102 | 6-7 | .462 | Madison Square Garden · Manhattan, NY |
| 14 | Mon Nov 18 | at Raptors | L96-132 | 6-8 | .429 | Scotiabank Arena · Toronto, ON |
| 15 | Wed Nov 20 | at Nets | L91-101 | 6-9 | .400 | Barclays Center · Brooklyn, NY |
| 16 | Fri Nov 22 | at Wizards | L118-125 | 6-10 | .375 | Capital One Arena · Washington, D.C. |
| 17 | Sat Nov 23 | vsBulls | L115-116 | 6-11 | .353 | Spectrum Center · Charlotte, NC |
| 18 | Mon Nov 25 | at Heat | L100-117 | 6-12 | .333 | FTX Arena · Miami, FL |
| 19 | Wed Nov 27 | vsPistons | W102-101 | 7-12 | .368 | Spectrum Center · Charlotte, NC |
| 20 | Fri Nov 29 | atPistons | W110-107 | 8-12 | .400 | Little Caesars Arena · Detroit, MI |
| 21 | Sat Nov 30 | at Bucks | L96-137 | 8-13 | .381 | Fiserv Forum · Milwaukee, WI |
| 22 | Mon Dec 2 | vs Suns | L104-109 | 8-14 | .364 | Spectrum Center · Charlotte, NC |
| 23 | Wed Dec 4 | vsWarriors | W106-91 | 9-14 | .391 | Spectrum Center · Charlotte, NC |
| 24 | Fri Dec 6 | vsNets | L104-111 | 9-15 | .375 | Spectrum Center · Charlotte, NC |
| 25 | Sun Dec 8 | vs Hawks | L107-122 | 9-16 | .360 | Spectrum Center · Charlotte, NC |
| 26 | Tue Dec 10 | vsWizards | W114-107 | 10-16 | .385 | Spectrum Center · Charlotte, NC |
| 27 | Wed Dec 11 | atNets | W113-108 | 11-16 | .407 | Barclays Center · Brooklyn, NY |
| 28 | Fri Dec 13 | atBulls | W83-73 | 12-16 | .429 | United Center · Chicago, IL |
| 29 | Sun Dec 15 | atPacers | L85-107 | 12-17 | .414 | Gainbridge Fieldhouse · Indianapolis, IN |
| 30 | Tue Dec 17 | vsKings | W110-102 | 13-17 | .433 | Spectrum Center · Charlotte, NC |
| 31 | Wed Dec 18 | at Cavaliers | L98-100 | 13-18 | .419 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 32 | Sat Dec 21 | vs Jazz | L107-114 | 13-19 | .406 | Spectrum Center · Charlotte, NC |
| 33 | Sun Dec 22 | atCeltics | L93-119 | 13-20 | .394 | TD Garden · Boston, MA |
| 34 | Fri Dec 27 | vs Thunder | L102-104 (OT) | 13-21 | .382 | Spectrum Center · Charlotte, NC |
| 35 | Sun Dec 29 | atGrizzlies | L104-117 | 13-22 | .371 | FedExForum · Memphis, TN |
| 36 | Tue Dec 31 | vsCeltics | L92-109 | 13-23 | .361 | Spectrum Center · Charlotte, NC |
| 37 | Thu Jan 2 | atCavaliers | W109-106 | 14-23 | .378 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 38 | Sat Jan 4 | at Mavericks | W123-120 (OT) | 15-23 | .395 | American Airlines Center · Dallas, TX |
| 39 | Mon Jan 6 | vsPacers | L104-115 | 15-24 | .385 | Spectrum Center · Charlotte, NC |
| 40 | Wed Jan 8 | vsRaptors | L110-112 (OT) | 15-25 | .375 | Spectrum Center · Charlotte, NC |
| 41 | Fri Jan 10 | atJazz | L92-109 | 15-26 | .366 | Vivint Arena · Salt Lake City, UT |
| 42 | Sun Jan 12 | atSuns | L92-100 | 15-27 | .357 | Footprint Center · Phoenix, AZ |
| 43 | Mon Jan 13 | at Blazers | L112-115 | 15-28 | .349 | Moda Center · Portland, OR |
| 44 | Wed Jan 15 | at Nuggets | L86-100 | 15-29 | .341 | Ball Arena · Denver, CO |
| 45 | Mon Jan 20 | vs Magic | L83-106 | 15-30 | .333 | Spectrum Center · Charlotte, NC |
| 46 | Fri Jan 24 | vsBucks | L103-116 | 15-31 | .326 | Spectrum Center · Charlotte, NC |
| 47 | Tue Jan 28 | vsKnicks | W97-92 | 16-31 | .340 | Spectrum Center · Charlotte, NC |
| 48 | Thu Jan 30 | atWizards | L107-121 | 16-32 | .333 | Capital One Arena · Washington, D.C. |
| 49 | Sat Feb 1 | at Spurs | L90-114 | 16-33 | .327 | AT&T Center · San Antonio, TX |
| 50 | Mon Feb 3 | vsMagic | L100-112 | 16-34 | .320 | Spectrum Center · Charlotte, NC |
| 51 | Tue Feb 4 | at Rockets | L110-125 | 16-35 | .314 | Toyota Center · Houston, TX |
| 52 | Sat Feb 8 | vsMavericks | L100-116 | 16-36 | .308 | Spectrum Center · Charlotte, NC |
| 53 | Mon Feb 10 | atPistons | W87-76 | 17-36 | .321 | Little Caesars Arena · Detroit, MI |
| 54 | Wed Feb 12 | atT-wolves | W115-108 | 18-36 | .333 | Target Center · Minneapolis, MN |
| 55 | Thu Feb 20 | atBulls | W103-93 | 19-36 | .345 | United Center · Chicago, IL |
| 56 | Sat Feb 22 | vsNets | L86-115 | 19-37 | .339 | Spectrum Center · Charlotte, NC |
| 57 | Tue Feb 25 | atPacers | L80-119 | 19-38 | .333 | Gainbridge Fieldhouse · Indianapolis, IN |
| 58 | Wed Feb 26 | vsKnicks | W107-101 | 20-38 | .345 | Spectrum Center · Charlotte, NC |
| 59 | Fri Feb 28 | atRaptors | W99-96 | 21-38 | .356 | Scotiabank Arena · Toronto, ON |
| 60 | Sun Mar 1 | vsBucks | L85-93 | 21-39 | .350 | Spectrum Center · Charlotte, NC |
| 61 | Tue Mar 3 | vsSpurs | L103-104 | 21-40 | .344 | Spectrum Center · Charlotte, NC |
| 62 | Thu Mar 5 | vsNuggets | L112-114 | 21-41 | .339 | Spectrum Center · Charlotte, NC |
| 63 | Sat Mar 7 | vsRockets | W108-99 | 22-41 | .349 | Spectrum Center · Charlotte, NC |
| 64 | Mon Mar 9 | atHawks | L138-143 (2OT) | 22-42 | .344 | State Farm Arena · Atlanta, GA |
| 65 | Wed Mar 11 | atHeat | W109-98 | 23-42 | .354 | FTX Arena · Miami, FL |
