| 1 | Wed Oct 20 | vs Pacers | W123-122 | 1-0 | 1.000 | Spectrum Center · Charlotte, NC |
| 2 | Fri Oct 22 | at Cavaliers | W123-112 | 2-0 | 1.000 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 3 | Sun Oct 24 | at Nets | W111-95 | 3-0 | 1.000 | Barclays Center · Brooklyn, NY |
| 4 | Mon Oct 25 | vs Celtics | L129-140 (OT) | 3-1 | .750 | Spectrum Center · Charlotte, NC |
| 5 | Wed Oct 27 | at Magic | W120-111 | 4-1 | .800 | Amway Center · Orlando, FL |
| 6 | Fri Oct 29 | at Heat | L99-114 | 4-2 | .667 | FTX Arena · Miami, FL |
| 7 | Sun Oct 31 | vs Blazers | W125-113 | 5-2 | .714 | Spectrum Center · Charlotte, NC |
| 8 | Mon Nov 1 | vsCavaliers | L110-113 | 5-3 | .625 | Spectrum Center · Charlotte, NC |
| 9 | Wed Nov 3 | at Warriors | L92-114 | 5-4 | .556 | Chase Center · San Francisco, CA |
| 10 | Fri Nov 5 | at Kings | L110-140 | 5-5 | .500 | Golden 1 Center · Sacramento, CA |
| 11 | Sun Nov 7 | at Clippers | L106-120 | 5-6 | .455 | Crypto.com Arena · Los Angeles, CA |
| 12 | Mon Nov 8 | at Lakers | L123-126 (OT) | 5-7 | .417 | Crypto.com Arena · Los Angeles, CA |
| 13 | Wed Nov 10 | at Grizzlies | W118-108 | 6-7 | .462 | FedExForum · Memphis, TN |
| 14 | Fri Nov 12 | vs Knicks | W104-96 | 7-7 | .500 | Spectrum Center · Charlotte, NC |
| 15 | Sun Nov 14 | vsWarriors | W106-102 | 8-7 | .533 | Spectrum Center · Charlotte, NC |
| 16 | Wed Nov 17 | vs Wizards | W97-87 | 9-7 | .563 | Spectrum Center · Charlotte, NC |
| 17 | Fri Nov 19 | vsPacers | W121-118 | 10-7 | .588 | Spectrum Center · Charlotte, NC |
| 18 | Sat Nov 20 | at Hawks | L105-115 | 10-8 | .556 | State Farm Arena · Atlanta, GA |
| 19 | Mon Nov 22 | atWizards | W109-103 | 11-8 | .579 | Capital One Arena · Washington, D.C. |
| 20 | Wed Nov 24 | atMagic | W106-99 | 12-8 | .600 | Amway Center · Orlando, FL |
| 21 | Fri Nov 26 | vs T-wolves | W133-115 | 13-8 | .619 | Spectrum Center · Charlotte, NC |
| 22 | Sat Nov 27 | at Rockets | L143-146 (OT) | 13-9 | .591 | Toyota Center · Houston, TX |
| 23 | Mon Nov 29 | at Bulls | L119-133 | 13-10 | .565 | United Center · Chicago, IL |
| 24 | Wed Dec 1 | at Bucks | L125-127 | 13-11 | .542 | Fiserv Forum · Milwaukee, WI |
| 25 | Sun Dec 5 | atHawks | W130-127 | 14-11 | .560 | State Farm Arena · Atlanta, GA |
| 26 | Mon Dec 6 | vs 76ers | L124-127 (OT) | 14-12 | .538 | Spectrum Center · Charlotte, NC |
| 27 | Wed Dec 8 | vs76ers | L106-110 | 14-13 | .519 | Spectrum Center · Charlotte, NC |
| 28 | Fri Dec 10 | vsKings | W124-123 | 15-13 | .536 | Spectrum Center · Charlotte, NC |
| 29 | Mon Dec 13 | at Mavericks | L96-120 | 15-14 | .517 | American Airlines Center · Dallas, TX |
| 30 | Wed Dec 15 | at Spurs | W131-115 | 16-14 | .533 | AT&T Center · San Antonio, TX |
| 31 | Fri Dec 17 | atBlazers | L116-125 | 16-15 | .516 | Moda Center · Portland, OR |
| 32 | Sun Dec 19 | at Suns | L106-137 | 16-16 | .500 | Footprint Center · Phoenix, AZ |
| 33 | Mon Dec 20 | at Jazz | L102-112 | 16-17 | .485 | Vivint Arena · Salt Lake City, UT |
| 34 | Thu Dec 23 | at Nuggets | W115-107 | 17-17 | .500 | Ball Arena · Denver, CO |
| 35 | Mon Dec 27 | vsRockets | W123-99 | 18-17 | .514 | Spectrum Center · Charlotte, NC |
| 36 | Wed Dec 29 | atPacers | W116-108 | 19-17 | .528 | Gainbridge Fieldhouse · Indianapolis, IN |
| 37 | Sun Jan 2 | vsSuns | L99-133 | 19-18 | .514 | Spectrum Center · Charlotte, NC |
| 38 | Mon Jan 3 | atWizards | L121-124 | 19-19 | .500 | Capital One Arena · Washington, D.C. |
| 39 | Wed Jan 5 | vs Pistons | W140-111 | 20-19 | .513 | Spectrum Center · Charlotte, NC |
| 40 | Sat Jan 8 | vsBucks | W114-106 | 21-19 | .525 | Spectrum Center · Charlotte, NC |
| 41 | Mon Jan 10 | vsBucks | W103-99 | 22-19 | .537 | Spectrum Center · Charlotte, NC |
| 42 | Wed Jan 12 | at76ers | W109-98 | 23-19 | .548 | Wells Fargo Center · Philadelphia, PA |
| 43 | Fri Jan 14 | vsMagic | L109-116 | 23-20 | .535 | Spectrum Center · Charlotte, NC |
| 44 | Mon Jan 17 | atKnicks | W97-87 | 24-20 | .545 | Madison Square Garden · Manhattan, NY |
| 45 | Wed Jan 19 | atCeltics | W111-102 | 25-20 | .556 | TD Garden · Boston, MA |
| 46 | Fri Jan 21 | vs Thunder | W121-98 | 26-20 | .565 | Spectrum Center · Charlotte, NC |
| 47 | Sun Jan 23 | vsHawks | L91-113 | 26-21 | .553 | Spectrum Center · Charlotte, NC |
| 48 | Tue Jan 25 | at Raptors | L113-125 | 26-22 | .542 | Scotiabank Arena · Toronto, ON |
| 49 | Wed Jan 26 | atPacers | W158-126 | 27-22 | .551 | Gainbridge Fieldhouse · Indianapolis, IN |
| 50 | Fri Jan 28 | vsLakers | W117-114 | 28-22 | .560 | Spectrum Center · Charlotte, NC |
| 51 | Sun Jan 30 | vsClippers | L90-115 | 28-23 | .549 | Spectrum Center · Charlotte, NC |
| 52 | Wed Feb 2 | atCeltics | L107-113 | 28-24 | .538 | TD Garden · Boston, MA |
| 53 | Fri Feb 4 | vsCavaliers | L101-102 | 28-25 | .528 | Spectrum Center · Charlotte, NC |
| 54 | Sat Feb 5 | vsHeat | L86-104 | 28-26 | .519 | Spectrum Center · Charlotte, NC |
| 55 | Mon Feb 7 | vsRaptors | L101-116 | 28-27 | .509 | Spectrum Center · Charlotte, NC |
| 56 | Wed Feb 9 | vsBulls | L109-121 | 28-28 | .500 | Spectrum Center · Charlotte, NC |
| 57 | Fri Feb 11 | atPistons | W141-119 | 29-28 | .509 | Little Caesars Arena · Detroit, MI |
| 58 | Sat Feb 12 | vsGrizzlies | L118-125 | 29-29 | .500 | Spectrum Center · Charlotte, NC |
| 59 | Tue Feb 15 | atT-wolves | L120-126 (OT) | 29-30 | .492 | Target Center · Minneapolis, MN |
| 60 | Thu Feb 17 | vsHeat | L107-111 (2OT) | 29-31 | .483 | Spectrum Center · Charlotte, NC |
| 61 | Fri Feb 25 | vsRaptors | W125-93 | 30-31 | .492 | Spectrum Center · Charlotte, NC |
| 62 | Sun Feb 27 | vsPistons | L126-127 (OT) | 30-32 | .484 | Spectrum Center · Charlotte, NC |
| 63 | Mon Feb 28 | atBucks | L106-130 | 30-33 | .476 | Fiserv Forum · Milwaukee, WI |
| 64 | Wed Mar 2 | atCavaliers | W119-98 | 31-33 | .484 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 65 | Sat Mar 5 | vsSpurs | W123-117 | 32-33 | .492 | Spectrum Center · Charlotte, NC |
| 66 | Tue Mar 8 | vsNets | L121-132 | 32-34 | .485 | Spectrum Center · Charlotte, NC |
| 67 | Wed Mar 9 | vsCeltics | L101-115 | 32-35 | .478 | Spectrum Center · Charlotte, NC |
| 68 | Fri Mar 11 | at Pelicans | W142-120 | 33-35 | .485 | Smoothie King Center · New Orleans, LA |
| 69 | Mon Mar 14 | atThunder | W134-116 | 34-35 | .493 | Paycom Center · Oklahoma City, OK |
| 70 | Wed Mar 16 | vsHawks | W116-106 | 35-35 | .500 | Spectrum Center · Charlotte, NC |
| 71 | Sat Mar 19 | vsMavericks | W129-108 | 36-35 | .507 | Spectrum Center · Charlotte, NC |
| 72 | Mon Mar 21 | vsPelicans | W106-103 | 37-35 | .514 | Spectrum Center · Charlotte, NC |
| 73 | Wed Mar 23 | vsKnicks | L106-121 | 37-36 | .507 | Spectrum Center · Charlotte, NC |
| 74 | Fri Mar 25 | vsJazz | W107-101 | 38-36 | .514 | Spectrum Center · Charlotte, NC |
| 75 | Sun Mar 27 | atNets | W119-110 | 39-36 | .520 | Barclays Center · Brooklyn, NY |
| 76 | Mon Mar 28 | vsNuggets | L109-113 | 39-37 | .513 | Spectrum Center · Charlotte, NC |
| 77 | Wed Mar 30 | atKnicks | W125-114 | 40-37 | .519 | Madison Square Garden · Manhattan, NY |
| 78 | Sat Apr 2 | at76ers | L114-144 | 40-38 | .513 | Wells Fargo Center · Philadelphia, PA |
| 79 | Tue Apr 5 | atHeat | L115-144 | 40-39 | .506 | FTX Arena · Miami, FL |
| 80 | Thu Apr 7 | vsMagic | W128-101 | 41-39 | .512 | Spectrum Center · Charlotte, NC |
| 81 | Fri Apr 8 | atBulls | W133-117 | 42-39 | .519 | United Center · Chicago, IL |
| 82 | Sun Apr 10 | vsWizards | W124-108 | 43-39 | .524 | Spectrum Center · Charlotte, NC |
| 0 | Wed Apr 13 | atHawks | L103-132 | 0-1 | .000 | State Farm Arena · Atlanta, GA |
