| 1 | Wed Oct 26 | vs T-wolves | W102-98 | 1-0 | 1.000 | | FedExForum · Memphis, TN |
| 2 | Sat Oct 29 | at Knicks | L104-111 | 1-1 | .500 | | Madison Square Garden · Manhattan, NY |
| 3 | Sun Oct 30 | vs Wizards | W112-103 (OT) | 2-1 | .667 | NBA TV | FedExForum · Memphis, TN |
| 4 | Tue Nov 1 | at T-wolves | L80-116 | 2-2 | .500 | | Target Center · Minneapolis, MN |
| 5 | Wed Nov 2 | vs Pelicans | W89-83 (OT) | 3-2 | .600 | | FedExForum · Memphis, TN |
| 6 | Fri Nov 4 | vs Clippers | L88-99 | 3-3 | .500 | | FedExForum · Memphis, TN |
| 7 | Sun Nov 6 | vs Blazers | L94-100 | 3-4 | .429 | | FedExForum · Memphis, TN |
| 8 | Tue Nov 8 | vs Nuggets | W108-107 | 4-4 | .500 | | FedExForum · Memphis, TN |
| 9 | Sat Nov 12 | at Bucks | L96-106 | 4-5 | .444 | | Fiserv Forum · Milwaukee, WI |
| 10 | Mon Nov 14 | at Jazz | W102-96 | 5-5 | .500 | | Vivint Arena · Salt Lake City, UT |
| 11 | Wed Nov 16 | at Clippers | W111-107 | 6-5 | .545 | ESPN | Intuit Dome · Inglewood, CA |
| 12 | Fri Nov 18 | at Mavericks | W80-64 | 7-5 | .583 | | American Airlines Center · Dallas, TX |
| 13 | Sat Nov 19 | vs T-wolves | W93-71 | 8-5 | .615 | NBA TV | FedExForum · Memphis, TN |
| 14 | Mon Nov 21 | at Hornets | W105-90 | 9-5 | .643 | | Spectrum Center · Charlotte, NC |
| 15 | Wed Nov 23 | at 76ers | W104-99 (2OT) | 10-5 | .667 | | Wells Fargo Center · Philadelphia, PA |
| 16 | Fri Nov 25 | vs Heat | L81-90 | 10-6 | .625 | | FedExForum · Memphis, TN |
| 17 | Sat Nov 26 | at Heat | W110-107 | 11-6 | .647 | | Kaseya Center · Miami, FL |
| 18 | Mon Nov 28 | vs Hornets | L85-104 | 11-7 | .611 | | FedExForum · Memphis, TN |
| 19 | Wed Nov 30 | at Raptors | L105-120 | 11-8 | .579 | | Scotiabank Arena · Toronto, ON |
| 20 | Thu Dec 1 | vs Magic | W95-94 | 12-8 | .600 | | FedExForum · Memphis, TN |
| 21 | Sat Dec 3 | vs Lakers | W103-100 | 13-8 | .619 | | FedExForum · Memphis, TN |
| 22 | Mon Dec 5 | at Pelicans | W110-108 (2OT) | 14-8 | .636 | | Smoothie King Center · New Orleans, LA |
| 23 | Tue Dec 6 | vs 76ers | W96-91 | 15-8 | .652 | | FedExForum · Memphis, TN |
| 24 | Thu Dec 8 | vs Blazers | W88-86 | 16-8 | .667 | | FedExForum · Memphis, TN |
| 25 | Sat Dec 10 | vs Warriors | W110-89 | 17-8 | .680 | | FedExForum · Memphis, TN |
| 26 | Tue Dec 13 | at Cavaliers | L86-103 | 17-9 | .654 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 27 | Wed Dec 14 | vs Cavaliers | W93-85 | 18-9 | .667 | | FedExForum · Memphis, TN |
| 28 | Fri Dec 16 | vs Kings | L92-96 | 18-10 | .643 | | FedExForum · Memphis, TN |
| 29 | Sun Dec 18 | vs Jazz | L73-82 | 18-11 | .621 | | FedExForum · Memphis, TN |
| 30 | Tue Dec 20 | vs Celtics | L109-112 (OT) | 18-12 | .600 | | FedExForum · Memphis, TN |
| 31 | Wed Dec 21 | at Pistons | W98-86 | 19-12 | .613 | | Little Caesars Arena · Detroit, MI |
| 32 | Fri Dec 23 | vs Rockets | W115-109 | 20-12 | .625 | | FedExForum · Memphis, TN |
| 33 | Mon Dec 26 | at Magic | L102-112 | 20-13 | .606 | | Amway Center · Orlando, FL |
| 34 | Tue Dec 27 | at Celtics | L103-113 | 20-14 | .588 | | TD Garden · Boston, MA |
| 35 | Thu Dec 29 | vs Thunder | W114-80 | 21-14 | .600 | | FedExForum · Memphis, TN |
| 36 | Sat Dec 31 | at Kings | W112-98 | 22-14 | .611 | | Golden 1 Center · Sacramento, CA |
| 37 | Tue Jan 3 | at Lakers | L102-116 | 22-15 | .595 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 38 | Wed Jan 4 | at Clippers | L106-115 | 22-16 | .579 | | Intuit Dome · Inglewood, CA |
| 39 | Fri Jan 6 | at Warriors | W128-119 (OT) | 23-16 | .590 | ESPN | Chase Center · San Francisco, CA |
| 40 | Sun Jan 8 | vs Jazz | W88-79 | 24-16 | .600 | NBA TV | FedExForum · Memphis, TN |
| 41 | Wed Jan 11 | at Thunder | L95-103 | 24-17 | .585 | ESPN | Paycom Center · Oklahoma City, OK |
| 42 | Fri Jan 13 | at Rockets | W110-105 | 25-17 | .595 | | Toyota Center · Houston, TX |
| 43 | Sun Jan 15 | vs Bulls | L104-108 | 25-18 | .581 | ESPN | FedExForum · Memphis, TN |
| 44 | Wed Jan 18 | at Wizards | L101-104 | 25-19 | .568 | | Capital One Arena · Washington, D.C. |
| 45 | Fri Jan 20 | vs Kings | W107-91 | 26-19 | .578 | | FedExForum · Memphis, TN |
| 46 | Sat Jan 21 | vs Rockets | L95-119 | 26-20 | .565 | | FedExForum · Memphis, TN |
| 47 | Wed Jan 25 | vs Raptors | W101-99 | 27-20 | .574 | | FedExForum · Memphis, TN |
| 48 | Fri Jan 27 | at Blazers | L109-112 | 27-21 | .563 | | Moda Center · Portland, OR |
| 49 | Sat Jan 28 | at Jazz | W102-95 | 28-21 | .571 | | Vivint Arena · Salt Lake City, UT |
| 50 | Mon Jan 30 | at Suns | W115-96 | 29-21 | .580 | TNT | Footprint Center · Phoenix, AZ |
| 51 | Wed Feb 1 | at Nuggets | W119-99 | 30-21 | .588 | | Ball Arena · Denver, CO |
| 52 | Fri Feb 3 | at Thunder | L102-114 | 30-22 | .577 | | Paycom Center · Oklahoma City, OK |
| 53 | Sat Feb 4 | at T-wolves | W107-99 | 31-22 | .585 | | Target Center · Minneapolis, MN |
| 54 | Mon Feb 6 | vs Spurs | W89-74 | 32-22 | .593 | TNT | FedExForum · Memphis, TN |
| 55 | Wed Feb 8 | vs Suns | W110-91 | 33-22 | .600 | | FedExForum · Memphis, TN |
| 56 | Fri Feb 10 | vs Warriors | L107-122 | 33-23 | .589 | | FedExForum · Memphis, TN |
| 57 | Mon Feb 13 | at Nets | W112-103 | 34-23 | .596 | | Barclays Center · Brooklyn, NY |
| 58 | Wed Feb 15 | vs Pelicans | L91-95 | 34-24 | .586 | | FedExForum · Memphis, TN |
| 59 | Fri Feb 24 | at Pacers | L92-102 | 34-25 | .576 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 60 | Sun Feb 26 | at Nuggets | W105-98 | 35-25 | .583 | | Ball Arena · Denver, CO |
| 61 | Tue Feb 28 | vs Suns | W130-112 | 36-25 | .590 | | FedExForum · Memphis, TN |
| 62 | Fri Mar 3 | at Mavericks | L100-104 | 36-26 | .581 | | American Airlines Center · Dallas, TX |
| 63 | Sat Mar 4 | at Rockets | L108-123 | 36-27 | .571 | | Toyota Center · Houston, TX |
| 64 | Mon Mar 6 | vs Nets | L109-122 | 36-28 | .563 | | FedExForum · Memphis, TN |
| 65 | Thu Mar 9 | vs Clippers | L98-114 | 36-29 | .554 | | FedExForum · Memphis, TN |
| 66 | Sat Mar 11 | vs Hawks | L90-107 | 36-30 | .545 | | FedExForum · Memphis, TN |
| 67 | Mon Mar 13 | vs Bucks | W113-93 | 37-30 | .552 | | FedExForum · Memphis, TN |
| 68 | Wed Mar 15 | at Bulls | W98-91 | 38-30 | .559 | | United Center · Chicago, IL |
| 69 | Thu Mar 16 | at Hawks | W103-91 | 39-30 | .565 | | State Farm Arena · Atlanta, GA |
| 70 | Sat Mar 18 | vs Spurs | W104-96 | 40-30 | .571 | | FedExForum · Memphis, TN |
| 71 | Tue Mar 21 | at Pelicans | L82-95 | 40-31 | .563 | | Smoothie King Center · New Orleans, LA |
| 72 | Thu Mar 23 | at Spurs | L90-97 | 40-32 | .556 | | AT&T Center · San Antonio, TX |
| 73 | Sun Mar 26 | at Warriors | L94-106 | 40-33 | .548 | | Chase Center · San Francisco, CA |
| 74 | Mon Mar 27 | at Kings | L90-91 | 40-34 | .541 | | Golden 1 Center · Sacramento, CA |
| 75 | Wed Mar 29 | vs Pacers | W110-97 | 41-34 | .547 | | FedExForum · Memphis, TN |
| 76 | Fri Mar 31 | vs Mavericks | W99-90 | 42-34 | .553 | | FedExForum · Memphis, TN |
| 77 | Sun Apr 2 | at Lakers | L103-108 | 42-35 | .545 | | Crypto.com Arena · Los Angeles, CA |
| 78 | Tue Apr 4 | at Spurs | L89-95 (OT) | 42-36 | .538 | | AT&T Center · San Antonio, TX |
| 79 | Wed Apr 5 | vs Thunder | L100-103 | 42-37 | .532 | | FedExForum · Memphis, TN |
| 80 | Fri Apr 7 | vs Knicks | W101-88 | 43-37 | .537 | | FedExForum · Memphis, TN |
| 81 | Sun Apr 9 | vs Pistons | L90-103 | 43-38 | .531 | | FedExForum · Memphis, TN |
| 82 | Wed Apr 12 | vs Mavericks | L93-100 | 43-39 | .524 | | FedExForum · Memphis, TN |
| 1 | Sat Apr 15 | at Spurs | L82-111 | 0-1 | .000 | ESPN | AT&T Center · San Antonio, TX |
| 2 | Mon Apr 17 | at Spurs | L82-96 | 0-2 | .000 | TNT | AT&T Center · San Antonio, TX |
| 3 | Thu Apr 20 | vs Spurs | W105-94 | 1-2 | .333 | TNT | FedExForum · Memphis, TN |
| 4 | Sat Apr 22 | vs Spurs | W110-108 (OT) | 2-2 | .500 | ESPN | FedExForum · Memphis, TN |
| 5 | Tue Apr 25 | at Spurs | L103-116 | 2-3 | .400 | NBA TV | AT&T Center · San Antonio, TX |
| 6 | Thu Apr 27 | vs Spurs | L96-103 | 2-4 | .333 | TNT | FedExForum · Memphis, TN |