| 1 | Wed Oct 19 | vs Knicks | W115-112 (OT) | 1-0 | 1.000 | ESPN | FedExForum · Memphis, TN |
| 2 | Fri Oct 21 | at Rockets | W129-122 | 2-0 | 1.000 | | Toyota Center · Houston, TX |
| 3 | Sat Oct 22 | at Mavericks | L96-137 | 2-1 | .667 | NBA TV | American Airlines Center · Dallas, TX |
| 4 | Mon Oct 24 | vs Nets | W134-124 | 3-1 | .750 | | FedExForum · Memphis, TN |
| 5 | Thu Oct 27 | at Kings | W125-110 | 4-1 | .800 | | Golden 1 Center · Sacramento, CA |
| 6 | Sat Oct 29 | at Jazz | L123-124 | 4-2 | .667 | | Vivint Arena · Salt Lake City, UT |
| 7 | Mon Oct 31 | at Jazz | L105-121 | 4-3 | .571 | | Vivint Arena · Salt Lake City, UT |
| 8 | Wed Nov 2 | at Blazers | W111-106 | 5-3 | .625 | ESPN | Moda Center · Portland, OR |
| 9 | Fri Nov 4 | vs Hornets | W130-99 | 6-3 | .667 | | FedExForum · Memphis, TN |
| 10 | Sun Nov 6 | vs Wizards | W103-97 | 7-3 | .700 | | FedExForum · Memphis, TN |
| 11 | Mon Nov 7 | vs Celtics | L106-109 | 7-4 | .636 | | FedExForum · Memphis, TN |
| 12 | Wed Nov 9 | at Spurs | W124-122 (OT) | 8-4 | .667 | | AT&T Center · San Antonio, TX |
| 13 | Fri Nov 11 | vs T-wolves | W114-103 | 9-4 | .692 | ESPN | FedExForum · Memphis, TN |
| 14 | Sun Nov 13 | at Wizards | L92-102 | 9-5 | .643 | | Capital One Arena · Washington, D.C. |
| 15 | Tue Nov 15 | at Pelicans | L102-113 | 9-6 | .600 | TNT | Smoothie King Center · New Orleans, LA |
| 16 | Fri Nov 18 | vs Thunder | W121-110 | 10-6 | .625 | | FedExForum · Memphis, TN |
| 17 | Sun Nov 20 | at Nets | L115-127 | 10-7 | .588 | | Barclays Center · Brooklyn, NY |
| 18 | Tue Nov 22 | vs Kings | L109-113 | 10-8 | .556 | | FedExForum · Memphis, TN |
| 19 | Fri Nov 25 | vs Pelicans | W132-111 | 11-8 | .579 | NBA TV | FedExForum · Memphis, TN |
| 20 | Sun Nov 27 | at Knicks | W127-123 | 12-8 | .600 | | Madison Square Garden · Manhattan, NY |
| 21 | Wed Nov 30 | at T-wolves | L101-109 | 12-9 | .571 | | Target Center · Minneapolis, MN |
| 22 | Fri Dec 2 | vs 76ers | W117-109 | 13-9 | .591 | | FedExForum · Memphis, TN |
| 23 | Sun Dec 4 | at Pistons | W122-112 | 14-9 | .609 | | Little Caesars Arena · Detroit, MI |
| 24 | Mon Dec 5 | vs Heat | W101-93 | 15-9 | .625 | | FedExForum · Memphis, TN |
| 25 | Wed Dec 7 | vs Thunder | W123-102 | 16-9 | .640 | | FedExForum · Memphis, TN |
| 26 | Fri Dec 9 | vs Pistons | W114-103 | 17-9 | .654 | | FedExForum · Memphis, TN |
| 27 | Mon Dec 12 | vs Hawks | W128-103 | 18-9 | .667 | NBA TV | FedExForum · Memphis, TN |
| 28 | Thu Dec 15 | vs Bucks | W142-101 | 19-9 | .679 | NBA TV | FedExForum · Memphis, TN |
| 29 | Sat Dec 17 | at Thunder | L109-115 | 19-10 | .655 | | Paycom Center · Oklahoma City, OK |
| 30 | Tue Dec 20 | at Nuggets | L91-105 | 19-11 | .633 | TNT | Ball Arena · Denver, CO |
| 31 | Fri Dec 23 | at Suns | W125-100 | 20-11 | .645 | ESPN | Footprint Center · Phoenix, AZ |
| 32 | Sun Dec 25 | at Warriors | L109-123 | 20-12 | .625 | ABC | Chase Center · San Francisco, CA |
| 33 | Tue Dec 27 | vs Suns | L108-125 | 20-13 | .606 | | FedExForum · Memphis, TN |
| 34 | Thu Dec 29 | at Raptors | W119-106 | 21-13 | .618 | | Scotiabank Arena · Toronto, ON |
| 35 | Sat Dec 31 | vs Pelicans | W116-101 | 22-13 | .629 | | FedExForum · Memphis, TN |
| 36 | Sun Jan 1 | vs Kings | W118-108 | 23-13 | .639 | | FedExForum · Memphis, TN |
| 37 | Wed Jan 4 | at Hornets | W131-107 | 24-13 | .649 | | Spectrum Center · Charlotte, NC |
| 38 | Thu Jan 5 | at Magic | W123-115 | 25-13 | .658 | | Amway Center · Orlando, FL |
| 39 | Sun Jan 8 | vs Jazz | W123-118 | 26-13 | .667 | | FedExForum · Memphis, TN |
| 40 | Mon Jan 9 | vs Spurs | W121-113 | 27-13 | .675 | | FedExForum · Memphis, TN |
| 41 | Wed Jan 11 | vs Spurs | W135-129 | 28-13 | .683 | | FedExForum · Memphis, TN |
| 42 | Sat Jan 14 | at Pacers | W130-112 | 29-13 | .690 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 43 | Mon Jan 16 | vs Suns | W136-106 | 30-13 | .698 | TNT | FedExForum · Memphis, TN |
| 44 | Wed Jan 18 | vs Cavaliers | W115-114 | 31-13 | .705 | | FedExForum · Memphis, TN |
| 45 | Fri Jan 20 | at Lakers | L121-122 | 31-14 | .689 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 46 | Sun Jan 22 | at Suns | L110-112 | 31-15 | .674 | | Footprint Center · Phoenix, AZ |
| 47 | Mon Jan 23 | at Kings | L100-133 | 31-16 | .660 | NBA TV | Golden 1 Center · Sacramento, CA |
| 48 | Wed Jan 25 | at Warriors | L120-122 | 31-17 | .646 | ESPN | Chase Center · San Francisco, CA |
| 49 | Fri Jan 27 | at T-wolves | L100-111 | 31-18 | .633 | NBA TV | Target Center · Minneapolis, MN |
| 50 | Sun Jan 29 | vs Pacers | W112-100 | 32-18 | .640 | | FedExForum · Memphis, TN |
| 51 | Wed Feb 1 | vs Blazers | L112-122 | 32-19 | .627 | | FedExForum · Memphis, TN |
| 52 | Thu Feb 2 | at Cavaliers | L113-128 | 32-20 | .615 | TNT | Rocket Mortgage FieldHouse · Cleveland, OH |
| 53 | Sun Feb 5 | vs Raptors | L103-106 | 32-21 | .604 | | FedExForum · Memphis, TN |
| 54 | Tue Feb 7 | vs Bulls | W104-89 | 33-21 | .611 | | FedExForum · Memphis, TN |
| 55 | Fri Feb 10 | vs T-wolves | W128-107 | 34-21 | .618 | | FedExForum · Memphis, TN |
| 56 | Sun Feb 12 | at Celtics | L109-119 | 34-22 | .607 | ABC | TD Garden · Boston, MA |
| 57 | Wed Feb 15 | vs Jazz | W117-111 | 35-22 | .614 | | FedExForum · Memphis, TN |
| --all-star break-- |
| 58 | Thu Feb 23 | at 76ers | L105-110 | 35-23 | .603 | TNT | Wells Fargo Center · Philadelphia, PA |
| 59 | Sat Feb 25 | vs Nuggets | W112-94 | 36-23 | .610 | | FedExForum · Memphis, TN |
| 60 | Tue Feb 28 | vs Lakers | W121-109 | 37-23 | .617 | TNT | FedExForum · Memphis, TN |
| 61 | Wed Mar 1 | at Rockets | W113-99 | 38-23 | .623 | | Toyota Center · Houston, TX |
| 62 | Fri Mar 3 | at Nuggets | L97-113 | 38-24 | .613 | ESPN | Ball Arena · Denver, CO |
| 63 | Sun Mar 5 | at Clippers | L129-135 | 38-25 | .603 | ESPN | Intuit Dome · Inglewood, CA |
| 64 | Tue Mar 7 | at Lakers | L103-112 | 38-26 | .594 | TNT | Crypto.com Arena · Los Angeles, CA |
| 65 | Thu Mar 9 | vs Warriors | W131-110 | 39-26 | .600 | TNT | FedExForum · Memphis, TN |
| 66 | Sat Mar 11 | vs Mavericks | W112-108 | 40-26 | .606 | | FedExForum · Memphis, TN |
| 67 | Mon Mar 13 | at Mavericks | W104-88 | 41-26 | .612 | ESPN | American Airlines Center · Dallas, TX |
| 68 | Wed Mar 15 | at Heat | L119-138 | 41-27 | .603 | | Kaseya Center · Miami, FL |
| 69 | Fri Mar 17 | at Spurs | W126-120 (OT) | 42-27 | .609 | | AT&T Center · San Antonio, TX |
| 70 | Sat Mar 18 | vs Warriors | W133-119 | 43-27 | .614 | NBA TV | FedExForum · Memphis, TN |
| 71 | Mon Mar 20 | vs Mavericks | W112-108 | 44-27 | .620 | NBA TV | FedExForum · Memphis, TN |
| 72 | Wed Mar 22 | vs Rockets | W130-125 | 45-27 | .625 | | FedExForum · Memphis, TN |
| 73 | Fri Mar 24 | vs Rockets | W151-114 | 46-27 | .630 | | FedExForum · Memphis, TN |
| 74 | Sun Mar 26 | at Hawks | W123-119 | 47-27 | .635 | NBA TV | State Farm Arena · Atlanta, GA |
| 75 | Tue Mar 28 | vs Magic | W113-108 | 48-27 | .640 | | FedExForum · Memphis, TN |
| 76 | Wed Mar 29 | vs Clippers | L132-141 | 48-28 | .632 | | FedExForum · Memphis, TN |
| 77 | Fri Mar 31 | vs Clippers | W108-94 | 49-28 | .636 | | FedExForum · Memphis, TN |
| 78 | Sun Apr 2 | at Bulls | L107-128 | 49-29 | .628 | | United Center · Chicago, IL |
| 79 | Tue Apr 4 | vs Blazers | W119-109 | 50-29 | .633 | | FedExForum · Memphis, TN |
| 80 | Wed Apr 5 | at Pelicans | L131-138 (OT) | 50-30 | .625 | | Smoothie King Center · New Orleans, LA |
| 81 | Fri Apr 7 | at Bucks | W137-114 | 51-30 | .630 | NBA TV | Fiserv Forum · Milwaukee, WI |
| 82 | Sun Apr 9 | at Thunder | L100-115 | 51-31 | .622 | | Paycom Center · Oklahoma City, OK |
| 1 | Sun Apr 16 | vs Lakers | L112-128 | 0-1 | .000 | ABC | FedExForum · Memphis, TN |
| 2 | Wed Apr 19 | vs Lakers | W103-93 | 1-1 | .500 | TNT | FedExForum · Memphis, TN |
| 3 | Sat Apr 22 | at Lakers | L101-111 | 1-2 | .333 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 4 | Mon Apr 24 | at Lakers | L111-117 (OT) | 1-3 | .250 | TNT | Crypto.com Arena · Los Angeles, CA |
| 5 | Wed Apr 26 | vs Lakers | W116-99 | 2-3 | .400 | TNT | FedExForum · Memphis, TN |
| 6 | Fri Apr 28 | at Lakers | L85-125 | 2-4 | .333 | ESPN | Crypto.com Arena · Los Angeles, CA |