| 1 | Wed Oct 20 | vs Cavaliers | W132-121 | 1-0 | 1.000 | | FedExForum · Memphis, TN |
| 2 | Sat Oct 23 | at Clippers | W120-114 | 2-0 | 1.000 | | Intuit Dome · Inglewood, CA |
| 3 | Sun Oct 24 | at Lakers | L118-121 | 2-1 | .667 | | Crypto.com Arena · Los Angeles, CA |
| 4 | Wed Oct 27 | at Blazers | L96-116 | 2-2 | .500 | ESPN | Moda Center · Portland, OR |
| 5 | Thu Oct 28 | at Warriors | W104-101 (OT) | 3-2 | .600 | | Chase Center · San Francisco, CA |
| 6 | Sat Oct 30 | vs Heat | L103-129 | 3-3 | .500 | | FedExForum · Memphis, TN |
| 7 | Mon Nov 1 | vs Nuggets | W106-97 | 4-3 | .571 | | FedExForum · Memphis, TN |
| 8 | Wed Nov 3 | vs Nuggets | W108-106 | 5-3 | .625 | | FedExForum · Memphis, TN |
| 9 | Fri Nov 5 | at Wizards | L87-115 | 5-4 | .556 | | Capital One Arena · Washington, D.C. |
| 10 | Mon Nov 8 | vs T-wolves | W125-118 (OT) | 6-4 | .600 | | FedExForum · Memphis, TN |
| 11 | Wed Nov 10 | vs Hornets | L108-118 | 6-5 | .545 | | FedExForum · Memphis, TN |
| 12 | Fri Nov 12 | vs Suns | L94-119 | 6-6 | .500 | | FedExForum · Memphis, TN |
| 13 | Sat Nov 13 | at Pelicans | L101-112 | 6-7 | .462 | | Smoothie King Center · New Orleans, LA |
| 14 | Mon Nov 15 | vs Rockets | W136-102 | 7-7 | .500 | | FedExForum · Memphis, TN |
| 15 | Thu Nov 18 | vs Clippers | W120-108 | 8-7 | .533 | | FedExForum · Memphis, TN |
| 16 | Sat Nov 20 | at T-wolves | L95-138 | 8-8 | .500 | | Target Center · Minneapolis, MN |
| 17 | Mon Nov 22 | at Jazz | W119-118 | 9-8 | .529 | | Vivint Arena · Salt Lake City, UT |
| 18 | Wed Nov 24 | vs Raptors | L113-126 | 9-9 | .500 | | FedExForum · Memphis, TN |
| 19 | Fri Nov 26 | vs Hawks | L100-132 | 9-10 | .474 | | FedExForum · Memphis, TN |
| 20 | Sun Nov 28 | vs Kings | W128-101 | 10-10 | .500 | | FedExForum · Memphis, TN |
| 21 | Tue Nov 30 | at Raptors | W98-91 | 11-10 | .524 | | Scotiabank Arena · Toronto, ON |
| 22 | Thu Dec 2 | vs Thunder | W152-79 | 12-10 | .545 | | FedExForum · Memphis, TN |
| 23 | Sat Dec 4 | at Mavericks | W97-90 | 13-10 | .565 | | American Airlines Center · Dallas, TX |
| 24 | Mon Dec 6 | at Heat | W105-90 | 14-10 | .583 | | Kaseya Center · Miami, FL |
| 25 | Wed Dec 8 | vs Mavericks | L96-104 | 14-11 | .560 | | FedExForum · Memphis, TN |
| 26 | Thu Dec 9 | vs Lakers | W108-95 | 15-11 | .577 | | FedExForum · Memphis, TN |
| 27 | Sat Dec 11 | vs Rockets | W113-106 | 16-11 | .593 | | FedExForum · Memphis, TN |
| 28 | Mon Dec 13 | vs 76ers | W126-91 | 17-11 | .607 | | FedExForum · Memphis, TN |
| 29 | Wed Dec 15 | at Blazers | W113-103 | 18-11 | .621 | | Moda Center · Portland, OR |
| 30 | Fri Dec 17 | at Kings | W124-105 | 19-11 | .633 | | Golden 1 Center · Sacramento, CA |
| 31 | Sun Dec 19 | vs Blazers | L100-105 | 19-12 | .613 | | FedExForum · Memphis, TN |
| 32 | Mon Dec 20 | vs Thunder | L99-102 | 19-13 | .594 | | FedExForum · Memphis, TN |
| 33 | Thu Dec 23 | at Warriors | L104-113 | 19-14 | .576 | | Chase Center · San Francisco, CA |
| 34 | Sun Dec 26 | at Kings | W127-102 | 20-14 | .588 | | Golden 1 Center · Sacramento, CA |
| 35 | Mon Dec 27 | at Suns | W114-113 | 21-14 | .600 | | Footprint Center · Phoenix, AZ |
| 36 | Wed Dec 29 | vs Lakers | W104-99 | 22-14 | .611 | NBA TV | FedExForum · Memphis, TN |
| 37 | Fri Dec 31 | vs Spurs | W118-105 | 23-14 | .622 | | FedExForum · Memphis, TN |
| 38 | Mon Jan 3 | at Nets | W118-104 | 24-14 | .632 | NBA TV | Barclays Center · Brooklyn, NY |
| 39 | Tue Jan 4 | at Cavaliers | W110-106 | 25-14 | .641 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 40 | Thu Jan 6 | vs Pistons | W118-88 | 26-14 | .650 | | FedExForum · Memphis, TN |
| 41 | Sat Jan 8 | at Clippers | W123-108 | 27-14 | .659 | | Intuit Dome · Inglewood, CA |
| 42 | Sun Jan 9 | at Lakers | W127-119 | 28-14 | .667 | | Crypto.com Arena · Los Angeles, CA |
| 43 | Tue Jan 11 | vs Warriors | W116-108 | 29-14 | .674 | NBA TV | FedExForum · Memphis, TN |
| 44 | Thu Jan 13 | vs T-wolves | W116-108 | 30-14 | .682 | | FedExForum · Memphis, TN |
| 45 | Fri Jan 14 | vs Mavericks | L85-112 | 30-15 | .667 | ESPN | FedExForum · Memphis, TN |
| 46 | Mon Jan 17 | vs Bulls | W119-106 | 31-15 | .674 | TNT | FedExForum · Memphis, TN |
| 47 | Wed Jan 19 | at Bucks | L114-126 | 31-16 | .660 | | Fiserv Forum · Milwaukee, WI |
| 48 | Fri Jan 21 | at Nuggets | W122-118 | 32-16 | .667 | | Ball Arena · Denver, CO |
| 49 | Sun Jan 23 | at Mavericks | L91-104 | 32-17 | .653 | | American Airlines Center · Dallas, TX |
| 50 | Wed Jan 26 | at Spurs | W118-110 | 33-17 | .660 | | AT&T Center · San Antonio, TX |
| 51 | Fri Jan 28 | vs Jazz | W119-109 | 34-17 | .667 | | FedExForum · Memphis, TN |
| 52 | Sat Jan 29 | vs Wizards | W115-95 | 35-17 | .673 | | FedExForum · Memphis, TN |
| 53 | Mon Jan 31 | at 76ers | L119-122 (OT) | 35-18 | .660 | | Wells Fargo Center · Philadelphia, PA |
| 54 | Wed Feb 2 | at Knicks | W120-108 | 36-18 | .667 | ESPN | Madison Square Garden · Manhattan, NY |
| 55 | Sat Feb 5 | at Magic | W135-115 | 37-18 | .673 | | Amway Center · Orlando, FL |
| 56 | Tue Feb 8 | vs Clippers | W135-109 | 38-18 | .679 | | FedExForum · Memphis, TN |
| 57 | Thu Feb 10 | at Pistons | W132-107 | 39-18 | .684 | | Little Caesars Arena · Detroit, MI |
| 58 | Sat Feb 12 | at Hornets | W125-118 | 40-18 | .690 | | Spectrum Center · Charlotte, NC |
| 59 | Tue Feb 15 | at Pelicans | W121-109 | 41-18 | .695 | | Smoothie King Center · New Orleans, LA |
| 60 | Wed Feb 16 | vs Blazers | L119-123 | 41-19 | .683 | | FedExForum · Memphis, TN |
| --all-star break-- |
| 61 | Thu Feb 24 | at T-wolves | L114-119 | 41-20 | .672 | | Target Center · Minneapolis, MN |
| 62 | Sat Feb 26 | at Bulls | W116-110 | 42-20 | .677 | | United Center · Chicago, IL |
| 63 | Mon Feb 28 | vs Spurs | W118-105 | 43-20 | .683 | | FedExForum · Memphis, TN |
| 64 | Thu Mar 3 | at Celtics | L107-120 | 43-21 | .672 | TNT | TD Garden · Boston, MA |
| 65 | Sat Mar 5 | vs Magic | W124-96 | 44-21 | .677 | | FedExForum · Memphis, TN |
| 66 | Sun Mar 6 | at Rockets | L112-123 | 44-22 | .667 | | Toyota Center · Houston, TX |
| 67 | Tue Mar 8 | vs Pelicans | W132-111 | 45-22 | .672 | TNT | FedExForum · Memphis, TN |
| 68 | Fri Mar 11 | vs Knicks | W118-114 | 46-22 | .676 | NBA TV | FedExForum · Memphis, TN |
| 69 | Sun Mar 13 | at Thunder | W125-118 | 47-22 | .681 | | Paycom Center · Oklahoma City, OK |
| 70 | Tue Mar 15 | at Pacers | W135-102 | 48-22 | .686 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 71 | Fri Mar 18 | at Hawks | L105-120 | 48-23 | .676 | NBA TV | State Farm Arena · Atlanta, GA |
| 72 | Sun Mar 20 | at Rockets | W122-98 | 49-23 | .681 | | Toyota Center · Houston, TX |
| 73 | Wed Mar 23 | vs Nets | W132-120 | 50-23 | .685 | ESPN | FedExForum · Memphis, TN |
| 74 | Thu Mar 24 | vs Pacers | W133-103 | 51-23 | .689 | | FedExForum · Memphis, TN |
| 75 | Sat Mar 26 | vs Bucks | W127-102 | 52-23 | .693 | | FedExForum · Memphis, TN |
| 76 | Mon Mar 28 | vs Warriors | W123-95 | 53-23 | .697 | NBA TV | FedExForum · Memphis, TN |
| 77 | Wed Mar 30 | at Spurs | W112-111 | 54-23 | .701 | | AT&T Center · San Antonio, TX |
| 78 | Fri Apr 1 | vs Suns | W122-114 | 55-23 | .705 | NBA TV | FedExForum · Memphis, TN |
| 79 | Tue Apr 5 | at Jazz | L115-121 (OT) | 55-24 | .696 | | Vivint Arena · Salt Lake City, UT |
| 80 | Thu Apr 7 | at Nuggets | L109-122 | 55-25 | .688 | | Ball Arena · Denver, CO |
| 81 | Sat Apr 9 | vs Pelicans | W141-114 | 56-25 | .691 | NBA TV | FedExForum · Memphis, TN |
| 82 | Sun Apr 10 | vs Celtics | L110-139 | 56-26 | .683 | TNT | FedExForum · Memphis, TN |
| 1 | Sat Apr 16 | vs T-wolves | L117-130 | 0-1 | .000 | ESPN | FedExForum · Memphis, TN |
| 2 | Tue Apr 19 | vs T-wolves | W124-96 | 1-1 | .500 | NBA TV | FedExForum · Memphis, TN |
| 3 | Thu Apr 21 | at T-wolves | W104-95 | 2-1 | .667 | TNT | Target Center · Minneapolis, MN |
| 4 | Sat Apr 23 | at T-wolves | L118-119 | 2-2 | .500 | ESPN | Target Center · Minneapolis, MN |
| 5 | Tue Apr 26 | vs T-wolves | W111-109 | 3-2 | .600 | TNT | FedExForum · Memphis, TN |
| 6 | Fri Apr 29 | at T-wolves | W114-106 | 4-2 | .667 | ESPN | Target Center · Minneapolis, MN |
| 1 | Sun May 1 | vs Warriors | L116-117 | 0-1 | .000 | ABC | FedExForum · Memphis, TN |
| 2 | Tue May 3 | vs Warriors | W106-101 | 1-1 | .500 | TNT | FedExForum · Memphis, TN |
| 3 | Sat May 7 | at Warriors | L112-142 | 1-2 | .333 | ABC | Chase Center · San Francisco, CA |
| 4 | Mon May 9 | at Warriors | L98-101 | 1-3 | .250 | TNT | Chase Center · San Francisco, CA |
| 5 | Wed May 11 | vs Warriors | W134-95 | 2-3 | .400 | TNT | FedExForum · Memphis, TN |
| 6 | Fri May 13 | at Warriors | L96-110 | 2-4 | .333 | ESPN | Chase Center · San Francisco, CA |