| 1 | Tue Oct 25 | vs Jazz | W113-104 | 1-0 | 1.000 | Moda Center · Portland, OR |
| 2 | Thu Oct 27 | vs Clippers | L106-114 | 1-1 | .500 | Moda Center · Portland, OR |
| 3 | Sat Oct 29 | at Nuggets | W115-113 (OT) | 2-1 | .667 | Ball Arena · Denver, CO |
| 4 | Tue Nov 1 | vs Warriors | L104-127 | 2-2 | .500 | Moda Center · Portland, OR |
| 5 | Wed Nov 2 | at Suns | L115-118 (OT) | 2-3 | .400 | Footprint Center · Phoenix, AZ |
| 6 | Fri Nov 4 | at Mavericks | W105-95 | 3-3 | .500 | American Airlines Center · Dallas, TX |
| 7 | Sun Nov 6 | at Grizzlies | W100-94 | 4-3 | .571 | FedExForum · Memphis, TN |
| 8 | Tue Nov 8 | vsSuns | W124-121 | 5-3 | .625 | Moda Center · Portland, OR |
| 9 | Wed Nov 9 | atClippers | L80-111 | 5-4 | .556 | Crypto.com Arena · Los Angeles, CA |
| 10 | Fri Nov 11 | vs Kings | W122-120 (OT) | 6-4 | .600 | Moda Center · Portland, OR |
| 11 | Sun Nov 13 | vsNuggets | W112-105 | 7-4 | .636 | Moda Center · Portland, OR |
| 12 | Tue Nov 15 | vs Bulls | L88-113 | 7-5 | .583 | Moda Center · Portland, OR |
| 13 | Thu Nov 17 | at Rockets | L109-126 | 7-6 | .538 | Toyota Center · Houston, TX |
| 14 | Fri Nov 18 | at Pelicans | L101-113 | 7-7 | .500 | Smoothie King Center · New Orleans, LA |
| 15 | Sun Nov 20 | at Nets | W129-109 | 8-7 | .533 | Barclays Center · Brooklyn, NY |
| 16 | Tue Nov 22 | at Knicks | L103-107 | 8-8 | .500 | Madison Square Garden · Manhattan, NY |
| 17 | Wed Nov 23 | at Cavaliers | L125-137 | 8-9 | .471 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 18 | Fri Nov 25 | vsPelicans | W119-104 | 9-9 | .500 | Moda Center · Portland, OR |
| 19 | Sun Nov 27 | vsRockets | L114-130 | 9-10 | .474 | Moda Center · Portland, OR |
| 20 | Wed Nov 30 | vs Pacers | W131-109 | 10-10 | .500 | Moda Center · Portland, OR |
| 21 | Sat Dec 3 | vs Heat | W99-92 | 11-10 | .524 | Moda Center · Portland, OR |
| 22 | Mon Dec 5 | atBulls | W112-110 | 12-10 | .545 | United Center · Chicago, IL |
| 23 | Wed Dec 7 | at Bucks | L107-115 | 12-11 | .522 | Fiserv Forum · Milwaukee, WI |
| 24 | Thu Dec 8 | atGrizzlies | L86-88 | 12-12 | .500 | FedExForum · Memphis, TN |
| 25 | Sat Dec 10 | atPacers | L111-118 | 12-13 | .480 | Gainbridge Fieldhouse · Indianapolis, IN |
| 26 | Mon Dec 12 | atClippers | L120-121 | 12-14 | .462 | Crypto.com Arena · Los Angeles, CA |
| 27 | Tue Dec 13 | vs Thunder | W114-95 | 13-14 | .481 | Moda Center · Portland, OR |
| 28 | Thu Dec 15 | atNuggets | L120-132 | 13-15 | .464 | Ball Arena · Denver, CO |
| 29 | Sat Dec 17 | atWarriors | L90-135 | 13-16 | .448 | Chase Center · San Francisco, CA |
| 30 | Tue Dec 20 | atKings | L121-126 | 13-17 | .433 | Golden 1 Center · Sacramento, CA |
| 31 | Wed Dec 21 | vsMavericks | L95-96 | 13-18 | .419 | Moda Center · Portland, OR |
| 32 | Fri Dec 23 | vs Spurs | L90-110 | 13-19 | .406 | Moda Center · Portland, OR |
| 33 | Mon Dec 26 | vs Raptors | L91-95 | 13-20 | .394 | Moda Center · Portland, OR |
| 34 | Wed Dec 28 | vsKings | W102-89 | 14-20 | .412 | Moda Center · Portland, OR |
| 35 | Fri Dec 30 | atSpurs | L94-110 | 14-21 | .400 | AT&T Center · San Antonio, TX |
| 36 | Sun Jan 1 | at T-wolves | W95-89 | 15-21 | .417 | Target Center · Minneapolis, MN |
| 37 | Wed Jan 4 | atWarriors | L117-125 | 15-22 | .405 | Chase Center · San Francisco, CA |
| 38 | Thu Jan 5 | vs Lakers | W118-109 | 16-22 | .421 | Moda Center · Portland, OR |
| 39 | Sun Jan 8 | vs Pistons | L124-125 (2OT) | 16-23 | .410 | Moda Center · Portland, OR |
| 40 | Tue Jan 10 | atLakers | W108-87 | 17-23 | .425 | Crypto.com Arena · Los Angeles, CA |
| 41 | Wed Jan 11 | vsCavaliers | W102-86 | 18-23 | .439 | Moda Center · Portland, OR |
| 42 | Fri Jan 13 | vs Magic | L109-115 | 18-24 | .429 | Moda Center · Portland, OR |
| 43 | Mon Jan 16 | at Wizards | L101-120 | 18-25 | .419 | Capital One Arena · Washington, D.C. |
| 44 | Wed Jan 18 | at Hornets | L85-107 | 18-26 | .409 | Spectrum Center · Charlotte, NC |
| 45 | Fri Jan 20 | at 76ers | L92-93 | 18-27 | .400 | Wells Fargo Center · Philadelphia, PA |
| 46 | Sat Jan 21 | at Celtics | W127-123 (OT) | 19-27 | .413 | TD Garden · Boston, MA |
| 47 | Wed Jan 25 | vsLakers | W105-98 | 20-27 | .426 | Moda Center · Portland, OR |
| 48 | Fri Jan 27 | vsGrizzlies | W112-109 | 21-27 | .438 | Moda Center · Portland, OR |
| 49 | Sun Jan 29 | vsWarriors | L111-113 | 21-28 | .429 | Moda Center · Portland, OR |
| 50 | Tue Jan 31 | vsHornets | W115-98 | 22-28 | .440 | Moda Center · Portland, OR |
| 51 | Fri Feb 3 | vsMavericks | L104-108 | 22-29 | .431 | Moda Center · Portland, OR |
| 52 | Sun Feb 5 | atThunder | L99-105 | 22-30 | .423 | Paycom Center · Oklahoma City, OK |
| 53 | Tue Feb 7 | atMavericks | W114-113 | 23-30 | .434 | American Airlines Center · Dallas, TX |
| 54 | Thu Feb 9 | vsCeltics | L111-120 | 23-31 | .426 | Moda Center · Portland, OR |
| 55 | Mon Feb 13 | vs Hawks | L104-109 (OT) | 23-32 | .418 | Moda Center · Portland, OR |
| 56 | Wed Feb 15 | atJazz | L88-111 | 23-33 | .411 | Vivint Arena · Salt Lake City, UT |
| 57 | Thu Feb 23 | atMagic | W112-103 | 24-33 | .421 | Amway Center · Orlando, FL |
| 58 | Sun Feb 26 | atRaptors | L106-112 | 24-34 | .414 | Scotiabank Arena · Toronto, ON |
| 59 | Tue Feb 28 | atPistons | L113-120 (OT) | 24-35 | .407 | Little Caesars Arena · Detroit, MI |
| 60 | Thu Mar 2 | vsThunder | W114-109 | 25-35 | .417 | Moda Center · Portland, OR |
| 61 | Sat Mar 4 | vsNets | W130-116 | 26-35 | .426 | Moda Center · Portland, OR |
| 62 | Tue Mar 7 | atThunder | W126-121 | 27-35 | .435 | Paycom Center · Oklahoma City, OK |
| 63 | Thu Mar 9 | vs76ers | W114-108 (OT) | 28-35 | .444 | Moda Center · Portland, OR |
| 64 | Sat Mar 11 | vsWizards | L124-125 (OT) | 28-36 | .438 | Moda Center · Portland, OR |
| 65 | Sun Mar 12 | atSuns | W110-101 | 29-36 | .446 | Footprint Center · Phoenix, AZ |
| 66 | Tue Mar 14 | atPelicans | L77-100 | 29-37 | .439 | Smoothie King Center · New Orleans, LA |
| 67 | Wed Mar 15 | atSpurs | W110-106 | 30-37 | .448 | AT&T Center · San Antonio, TX |
| 68 | Sat Mar 18 | atHawks | W113-97 | 31-37 | .456 | State Farm Arena · Atlanta, GA |
| 69 | Sun Mar 19 | atHeat | W115-104 | 32-37 | .464 | FTX Arena · Miami, FL |
| 70 | Tue Mar 21 | vsBucks | L90-93 | 32-38 | .457 | Moda Center · Portland, OR |
| 71 | Thu Mar 23 | vsKnicks | W110-95 | 33-38 | .465 | Moda Center · Portland, OR |
| 72 | Sat Mar 25 | vsT-wolves | W112-100 | 34-38 | .472 | Moda Center · Portland, OR |
| 73 | Sun Mar 26 | atLakers | W97-81 | 35-38 | .479 | Crypto.com Arena · Los Angeles, CA |
| 74 | Tue Mar 28 | vsNuggets | W122-113 | 36-38 | .486 | Moda Center · Portland, OR |
| 75 | Thu Mar 30 | vsRockets | W117-107 | 37-38 | .493 | Moda Center · Portland, OR |
| 76 | Sat Apr 1 | vsSuns | W130-117 | 38-38 | .500 | Moda Center · Portland, OR |
| 77 | Mon Apr 3 | atT-wolves | L109-110 | 38-39 | .494 | Target Center · Minneapolis, MN |
| 78 | Tue Apr 4 | atJazz | L87-106 | 38-40 | .487 | Vivint Arena · Salt Lake City, UT |
| 79 | Thu Apr 6 | vsT-wolves | W105-98 | 39-40 | .494 | Moda Center · Portland, OR |
| 80 | Sat Apr 8 | vsJazz | W101-86 | 40-40 | .500 | Moda Center · Portland, OR |
| 81 | Mon Apr 10 | vsSpurs | W99-98 | 41-40 | .506 | Moda Center · Portland, OR |
| 82 | Wed Apr 12 | vsPelicans | L100-103 | 41-41 | .500 | Moda Center · Portland, OR |
| 1 | Sun Apr 16 | atWarriors | L109-121 | 0-1 | .000 | Chase Center · San Francisco, CA |
| 2 | Wed Apr 19 | atWarriors | L81-110 | 0-2 | .000 | Chase Center · San Francisco, CA |
| 3 | Sat Apr 22 | vsWarriors | L113-119 | 0-3 | .000 | Moda Center · Portland, OR |
| 4 | Mon Apr 24 | vsWarriors | L103-128 | 0-4 | .000 | Moda Center · Portland, OR |
