| 1 | Wed Oct 26 | vs Pistons | W109-91 | 1-0 | 1.000 | | Scotiabank Arena · Toronto, ON |
| 2 | Fri Oct 28 | vs Cavaliers | L91-94 | 1-1 | .500 | ESPN | Scotiabank Arena · Toronto, ON |
| 3 | Mon Oct 31 | vs Nuggets | W105-102 | 2-1 | .667 | | Scotiabank Arena · Toronto, ON |
| 4 | Wed Nov 2 | at Wizards | W113-103 | 3-1 | .750 | | Capital One Arena · Washington, D.C. |
| 5 | Fri Nov 4 | vs Heat | W96-87 | 4-1 | .800 | | Scotiabank Arena · Toronto, ON |
| 6 | Sun Nov 6 | vs Kings | L91-96 | 4-2 | .667 | | Scotiabank Arena · Toronto, ON |
| 7 | Wed Nov 9 | at Thunder | W112-102 | 5-2 | .714 | | Paycom Center · Oklahoma City, OK |
| 8 | Fri Nov 11 | at Hornets | W113-111 | 6-2 | .750 | | Spectrum Center · Charlotte, NC |
| 9 | Sat Nov 12 | vs Knicks | W118-107 | 7-2 | .778 | | Scotiabank Arena · Toronto, ON |
| 10 | Tue Nov 15 | at Cavaliers | L117-121 | 7-3 | .700 | NBA TV | Rocket Mortgage FieldHouse · Cleveland, OH |
| 11 | Wed Nov 16 | vs Warriors | L121-127 | 7-4 | .636 | ESPN | Scotiabank Arena · Toronto, ON |
| 12 | Fri Nov 18 | at Nuggets | W113-111 (OT) | 8-4 | .667 | | Ball Arena · Denver, CO |
| 13 | Sun Nov 20 | at Kings | L99-102 | 8-5 | .615 | | Golden 1 Center · Sacramento, CA |
| 14 | Mon Nov 21 | at Clippers | L115-123 | 8-6 | .571 | | Intuit Dome · Inglewood, CA |
| 15 | Wed Nov 23 | at Rockets | W115-102 | 9-6 | .600 | | Toyota Center · Houston, TX |
| 16 | Fri Nov 25 | at Bucks | W105-99 | 10-6 | .625 | | Fiserv Forum · Milwaukee, WI |
| 17 | Mon Nov 28 | vs 76ers | W122-95 | 11-6 | .647 | | Scotiabank Arena · Toronto, ON |
| 18 | Wed Nov 30 | vs Grizzlies | W120-105 | 12-6 | .667 | | Scotiabank Arena · Toronto, ON |
| 19 | Fri Dec 2 | vs Lakers | W113-80 | 13-6 | .684 | | Scotiabank Arena · Toronto, ON |
| 20 | Sat Dec 3 | vs Hawks | W128-84 | 14-6 | .700 | | Scotiabank Arena · Toronto, ON |
| 21 | Mon Dec 5 | vs Cavaliers | L112-116 | 14-7 | .667 | | Scotiabank Arena · Toronto, ON |
| 22 | Thu Dec 8 | vs T-wolves | W124-110 | 15-7 | .682 | TNT | Scotiabank Arena · Toronto, ON |
| 23 | Fri Dec 9 | at Celtics | W101-94 | 16-7 | .696 | | TD Garden · Boston, MA |
| 24 | Mon Dec 12 | vs Bucks | W122-100 | 17-7 | .708 | | Scotiabank Arena · Toronto, ON |
| 25 | Wed Dec 14 | at 76ers | W123-114 | 18-7 | .720 | | Wells Fargo Center · Philadelphia, PA |
| 26 | Fri Dec 16 | vs Hawks | L121-125 | 18-8 | .692 | | Scotiabank Arena · Toronto, ON |
| 27 | Sun Dec 18 | at Magic | W109-79 | 19-8 | .704 | | Amway Center · Orlando, FL |
| 28 | Tue Dec 20 | vs Nets | W116-104 | 20-8 | .714 | | Scotiabank Arena · Toronto, ON |
| 29 | Fri Dec 23 | at Jazz | W104-98 | 21-8 | .724 | | Vivint Arena · Salt Lake City, UT |
| 30 | Mon Dec 26 | at Blazers | W95-91 | 22-8 | .733 | | Moda Center · Portland, OR |
| 31 | Wed Dec 28 | at Warriors | L111-121 | 22-9 | .710 | NBA TV | Chase Center · San Francisco, CA |
| 32 | Thu Dec 29 | at Suns | L91-99 | 22-10 | .688 | | Footprint Center · Phoenix, AZ |
| 33 | Sun Jan 1 | at Lakers | W123-114 | 23-10 | .697 | | Crypto.com Arena · Los Angeles, CA |
| 34 | Tue Jan 3 | at Spurs | L82-110 | 23-11 | .676 | | AT&T Center · San Antonio, TX |
| 35 | Thu Jan 5 | vs Jazz | W101-93 | 24-11 | .686 | | Scotiabank Arena · Toronto, ON |
| 36 | Sat Jan 7 | at Bulls | L118-123 (OT) | 24-12 | .667 | | United Center · Chicago, IL |
| 37 | Sun Jan 8 | vs Rockets | L122-129 | 24-13 | .649 | | Scotiabank Arena · Toronto, ON |
| 38 | Tue Jan 10 | vs Celtics | W114-106 | 25-13 | .658 | NBA TV | Scotiabank Arena · Toronto, ON |
| 39 | Fri Jan 13 | vs Nets | W132-113 | 26-13 | .667 | | Scotiabank Arena · Toronto, ON |
| 40 | Sun Jan 15 | vs Knicks | W116-101 | 27-13 | .675 | | Scotiabank Arena · Toronto, ON |
| 41 | Tue Jan 17 | at Nets | W119-109 | 28-13 | .683 | | Barclays Center · Brooklyn, NY |
| 42 | Wed Jan 18 | at 76ers | L89-94 | 28-14 | .667 | | Wells Fargo Center · Philadelphia, PA |
| 43 | Fri Jan 20 | at Hornets | L78-113 | 28-15 | .651 | | Spectrum Center · Charlotte, NC |
| 44 | Sun Jan 22 | vs Suns | L103-115 | 28-16 | .636 | | Scotiabank Arena · Toronto, ON |
| 45 | Tue Jan 24 | vs Spurs | L106-108 | 28-17 | .622 | NBA TV | Scotiabank Arena · Toronto, ON |
| 46 | Wed Jan 25 | at Grizzlies | L99-101 | 28-18 | .609 | | FedExForum · Memphis, TN |
| 47 | Fri Jan 27 | vs Bucks | W102-86 | 29-18 | .617 | | Scotiabank Arena · Toronto, ON |
| 48 | Sun Jan 29 | vs Magic | L113-114 | 29-19 | .604 | | Scotiabank Arena · Toronto, ON |
| 49 | Tue Jan 31 | vs Pelicans | W108-106 (OT) | 30-19 | .612 | | Scotiabank Arena · Toronto, ON |
| 50 | Wed Feb 1 | at Celtics | L104-109 | 30-20 | .600 | | TD Garden · Boston, MA |
| 51 | Fri Feb 3 | at Magic | L94-102 | 30-21 | .588 | | Amway Center · Orlando, FL |
| 52 | Sun Feb 5 | at Nets | W103-95 | 31-21 | .596 | | Barclays Center · Brooklyn, NY |
| 53 | Mon Feb 6 | vs Clippers | W118-109 | 32-21 | .604 | | Scotiabank Arena · Toronto, ON |
| 54 | Wed Feb 8 | at T-wolves | L109-112 | 32-22 | .593 | | Target Center · Minneapolis, MN |
| 55 | Sun Feb 12 | vs Pistons | L101-102 | 32-23 | .582 | NBA TV | Scotiabank Arena · Toronto, ON |
| 56 | Tue Feb 14 | at Bulls | L94-105 | 32-24 | .571 | | United Center · Chicago, IL |
| 57 | Wed Feb 15 | vs Hornets | W90-85 | 33-24 | .579 | | Scotiabank Arena · Toronto, ON |
| 58 | Fri Feb 24 | vs Celtics | W107-97 | 34-24 | .586 | ESPN | Scotiabank Arena · Toronto, ON |
| 59 | Sun Feb 26 | vs Blazers | W112-106 | 35-24 | .593 | | Scotiabank Arena · Toronto, ON |
| 60 | Mon Feb 27 | at Knicks | W92-91 | 36-24 | .600 | | Madison Square Garden · Manhattan, NY |
| 61 | Wed Mar 1 | vs Wizards | L96-105 | 36-25 | .590 | | Scotiabank Arena · Toronto, ON |
| 62 | Fri Mar 3 | at Wizards | W114-106 | 37-25 | .597 | | Capital One Arena · Washington, D.C. |
| 63 | Sat Mar 4 | at Bucks | L94-101 | 37-26 | .587 | | Fiserv Forum · Milwaukee, WI |
| 64 | Wed Mar 8 | at Pelicans | W94-87 | 38-26 | .594 | | Smoothie King Center · New Orleans, LA |
| 65 | Fri Mar 10 | at Hawks | L99-105 | 38-27 | .585 | | State Farm Arena · Atlanta, GA |
| 66 | Sat Mar 11 | at Heat | L89-104 | 38-28 | .576 | | Kaseya Center · Miami, FL |
| 67 | Mon Mar 13 | vs Mavericks | W100-78 | 39-28 | .582 | | Scotiabank Arena · Toronto, ON |
| 68 | Thu Mar 16 | vs Thunder | L102-123 | 39-29 | .574 | | Scotiabank Arena · Toronto, ON |
| 69 | Fri Mar 17 | at Pistons | W87-75 | 40-29 | .580 | | Little Caesars Arena · Detroit, MI |
| 70 | Sun Mar 19 | vs Pacers | W116-91 | 41-29 | .586 | NBA TV | Scotiabank Arena · Toronto, ON |
| 71 | Tue Mar 21 | vs Bulls | W122-120 (OT) | 42-29 | .592 | ESPN | Scotiabank Arena · Toronto, ON |
| 72 | Thu Mar 23 | at Heat | W101-84 | 43-29 | .597 | NBA TV | Kaseya Center · Miami, FL |
| 73 | Sat Mar 25 | at Mavericks | W94-86 | 44-29 | .603 | | American Airlines Center · Dallas, TX |
| 74 | Mon Mar 27 | vs Magic | W131-112 | 45-29 | .608 | | Scotiabank Arena · Toronto, ON |
| 75 | Wed Mar 29 | vs Hornets | L106-110 | 45-30 | .600 | | Scotiabank Arena · Toronto, ON |
| 76 | Fri Mar 31 | vs Pacers | W111-100 | 46-30 | .605 | | Scotiabank Arena · Toronto, ON |
| 77 | Sun Apr 2 | vs 76ers | W113-105 | 47-30 | .610 | | Scotiabank Arena · Toronto, ON |
| 78 | Tue Apr 4 | at Pacers | L90-108 | 47-31 | .603 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 79 | Wed Apr 5 | at Pistons | W105-102 | 48-31 | .608 | | Little Caesars Arena · Detroit, MI |
| 80 | Fri Apr 7 | vs Heat | W96-94 | 49-31 | .613 | | Scotiabank Arena · Toronto, ON |
| 81 | Sun Apr 9 | at Knicks | W110-97 | 50-31 | .617 | NBA TV | Madison Square Garden · Manhattan, NY |
| 82 | Wed Apr 12 | at Cavaliers | W98-83 | 51-31 | .622 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 1 | Sat Apr 15 | vs Bucks | L83-97 | 0-1 | .000 | ESPN | Scotiabank Arena · Toronto, ON |
| 2 | Tue Apr 18 | vs Bucks | W106-100 | 1-1 | .500 | NBA TV | Scotiabank Arena · Toronto, ON |
| 3 | Thu Apr 20 | at Bucks | L77-104 | 1-2 | .333 | NBA TV | Fiserv Forum · Milwaukee, WI |
| 4 | Sat Apr 22 | at Bucks | W87-76 | 2-2 | .500 | TNT | Fiserv Forum · Milwaukee, WI |
| 5 | Mon Apr 24 | vs Bucks | W118-93 | 3-2 | .600 | NBA TV | Scotiabank Arena · Toronto, ON |
| 6 | Thu Apr 27 | at Bucks | W92-89 | 4-2 | .667 | TNT | Fiserv Forum · Milwaukee, WI |
| 1 | Mon May 1 | at Cavaliers | L105-116 | 0-1 | .000 | TNT | Rocket Mortgage FieldHouse · Cleveland, OH |
| 2 | Wed May 3 | at Cavaliers | L103-125 | 0-2 | .000 | TNT | Rocket Mortgage FieldHouse · Cleveland, OH |
| 3 | Fri May 5 | vs Cavaliers | L94-115 | 0-3 | .000 | ESPN | Scotiabank Arena · Toronto, ON |
| 4 | Sun May 7 | vs Cavaliers | L102-109 | 0-4 | .000 | ABC | Scotiabank Arena · Toronto, ON |