| 1 | Thu Oct 19 | vs Bulls | W117-100 | 1-0 | 1.000 | | Scotiabank Arena · Toronto, ON |
| 2 | Sat Oct 21 | vs 76ers | W128-94 | 2-0 | 1.000 | | Scotiabank Arena · Toronto, ON |
| 3 | Mon Oct 23 | at Spurs | L97-101 | 2-1 | .667 | NBA TV | AT&T Center · San Antonio, TX |
| 4 | Wed Oct 25 | at Warriors | L112-117 | 2-2 | .500 | | Chase Center · San Francisco, CA |
| 5 | Fri Oct 27 | at Lakers | W101-92 | 3-2 | .600 | | Crypto.com Arena · Los Angeles, CA |
| 6 | Mon Oct 30 | at Blazers | W99-85 | 4-2 | .667 | | Moda Center · Portland, OR |
| 7 | Wed Nov 1 | at Nuggets | L111-129 | 4-3 | .571 | | Ball Arena · Denver, CO |
| 8 | Fri Nov 3 | at Jazz | W109-100 | 5-3 | .625 | | Vivint Arena · Salt Lake City, UT |
| 9 | Sun Nov 5 | vs Wizards | L96-107 | 5-4 | .556 | | Scotiabank Arena · Toronto, ON |
| 10 | Tue Nov 7 | vs Bulls | W119-114 | 6-4 | .600 | | Scotiabank Arena · Toronto, ON |
| 11 | Thu Nov 9 | vs Pelicans | W122-118 | 7-4 | .636 | | Scotiabank Arena · Toronto, ON |
| 12 | Sun Nov 12 | at Celtics | L94-95 | 7-5 | .583 | | TD Garden · Boston, MA |
| 13 | Tue Nov 14 | at Rockets | W129-113 | 8-5 | .615 | NBA TV | Toyota Center · Houston, TX |
| 14 | Wed Nov 15 | at Pelicans | W125-116 | 9-5 | .643 | | Smoothie King Center · New Orleans, LA |
| 15 | Fri Nov 17 | vs Knicks | W107-84 | 10-5 | .667 | | Scotiabank Arena · Toronto, ON |
| 16 | Sun Nov 19 | vs Wizards | W100-91 | 11-5 | .688 | | Scotiabank Arena · Toronto, ON |
| 17 | Wed Nov 22 | at Knicks | L100-108 | 11-6 | .647 | | Madison Square Garden · Manhattan, NY |
| 18 | Fri Nov 24 | at Pacers | L104-107 | 11-7 | .611 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 19 | Sat Nov 25 | at Hawks | W112-78 | 12-7 | .632 | | State Farm Arena · Atlanta, GA |
| 20 | Wed Nov 29 | vs Hornets | W126-113 | 13-7 | .650 | | Scotiabank Arena · Toronto, ON |
| 21 | Fri Dec 1 | vs Pacers | W120-115 | 14-7 | .667 | | Scotiabank Arena · Toronto, ON |
| 22 | Tue Dec 5 | vs Suns | W126-113 | 15-7 | .682 | NBA TV | Scotiabank Arena · Toronto, ON |
| 23 | Fri Dec 8 | at Grizzlies | W116-107 | 16-7 | .696 | | FedExForum · Memphis, TN |
| 24 | Sun Dec 10 | at Kings | W102-87 | 17-7 | .708 | | Golden 1 Center · Sacramento, CA |
| 25 | Mon Dec 11 | at Clippers | L91-96 | 17-8 | .680 | NBA TV | Intuit Dome · Inglewood, CA |
| 26 | Wed Dec 13 | at Suns | W115-109 | 18-8 | .692 | | Footprint Center · Phoenix, AZ |
| 27 | Fri Dec 15 | vs Nets | W120-87 | 19-8 | .704 | | Scotiabank Arena · Toronto, ON |
| 28 | Sun Dec 17 | vs Kings | W108-93 | 20-8 | .714 | | Scotiabank Arena · Toronto, ON |
| 29 | Wed Dec 20 | at Hornets | W129-111 | 21-8 | .724 | | Spectrum Center · Charlotte, NC |
| 30 | Thu Dec 21 | at 76ers | W114-109 | 22-8 | .733 | | Wells Fargo Center · Philadelphia, PA |
| 31 | Sat Dec 23 | vs 76ers | W102-86 | 23-8 | .742 | | Scotiabank Arena · Toronto, ON |
| 32 | Tue Dec 26 | at Mavericks | L93-98 | 23-9 | .719 | | American Airlines Center · Dallas, TX |
| 33 | Wed Dec 27 | at Thunder | L107-124 | 23-10 | .697 | NBA TV | Paycom Center · Oklahoma City, OK |
| 34 | Fri Dec 29 | vs Hawks | W111-98 | 24-10 | .706 | | Scotiabank Arena · Toronto, ON |
| 35 | Mon Jan 1 | vs Bucks | W131-127 (OT) | 25-10 | .714 | | Scotiabank Arena · Toronto, ON |
| 36 | Wed Jan 3 | at Bulls | W124-115 | 26-10 | .722 | | United Center · Chicago, IL |
| 37 | Fri Jan 5 | at Bucks | W129-110 | 27-10 | .730 | | Fiserv Forum · Milwaukee, WI |
| 38 | Mon Jan 8 | at Nets | W114-113 (OT) | 28-10 | .737 | | Barclays Center · Brooklyn, NY |
| 39 | Tue Jan 9 | vs Heat | L89-90 | 28-11 | .718 | | Scotiabank Arena · Toronto, ON |
| 40 | Thu Jan 11 | vs Cavaliers | W133-99 | 29-11 | .725 | TNT | Scotiabank Arena · Toronto, ON |
| 41 | Sat Jan 13 | vs Warriors | L125-127 | 29-12 | .707 | | Scotiabank Arena · Toronto, ON |
| 42 | Mon Jan 15 | at 76ers | L111-117 | 29-13 | .690 | | Wells Fargo Center · Philadelphia, PA |
| 43 | Wed Jan 17 | vs Pistons | W96-91 | 30-13 | .698 | | Scotiabank Arena · Toronto, ON |
| 44 | Fri Jan 19 | vs Spurs | W86-83 | 31-13 | .705 | | Scotiabank Arena · Toronto, ON |
| 45 | Sat Jan 20 | at T-wolves | L109-115 | 31-14 | .689 | | Target Center · Minneapolis, MN |
| 46 | Wed Jan 24 | at Hawks | W108-93 | 32-14 | .696 | | State Farm Arena · Atlanta, GA |
| 47 | Fri Jan 26 | vs Jazz | L93-97 | 32-15 | .681 | | Scotiabank Arena · Toronto, ON |
| 48 | Sun Jan 28 | vs Lakers | W123-111 | 33-15 | .688 | | Scotiabank Arena · Toronto, ON |
| 49 | Tue Jan 30 | vs T-wolves | W109-104 | 34-15 | .694 | | Scotiabank Arena · Toronto, ON |
| 50 | Thu Feb 1 | at Wizards | L119-122 | 34-16 | .680 | | Capital One Arena · Washington, D.C. |
| 51 | Fri Feb 2 | vs Blazers | W130-105 | 35-16 | .686 | | Scotiabank Arena · Toronto, ON |
| 52 | Sun Feb 4 | vs Grizzlies | W101-86 | 36-16 | .692 | | Scotiabank Arena · Toronto, ON |
| 53 | Tue Feb 6 | vs Celtics | W111-91 | 37-16 | .698 | | Scotiabank Arena · Toronto, ON |
| 54 | Thu Feb 8 | vs Knicks | W113-88 | 38-16 | .704 | | Scotiabank Arena · Toronto, ON |
| 55 | Sun Feb 11 | at Hornets | W123-103 | 39-16 | .709 | | Spectrum Center · Charlotte, NC |
| 56 | Tue Feb 13 | vs Heat | W115-112 | 40-16 | .714 | | Scotiabank Arena · Toronto, ON |
| 57 | Wed Feb 14 | at Bulls | W122-98 | 41-16 | .719 | | United Center · Chicago, IL |
| 58 | Fri Feb 23 | vs Bucks | L119-122 (OT) | 41-17 | .707 | | Scotiabank Arena · Toronto, ON |
| 59 | Mon Feb 26 | vs Pistons | W123-94 | 42-17 | .712 | | Scotiabank Arena · Toronto, ON |
| 60 | Wed Feb 28 | at Magic | W117-104 | 43-17 | .717 | | Amway Center · Orlando, FL |
| 61 | Fri Mar 2 | at Wizards | W102-95 | 44-17 | .721 | ESPN | Capital One Arena · Washington, D.C. |
| 62 | Sun Mar 4 | vs Hornets | W103-98 | 45-17 | .726 | | Scotiabank Arena · Toronto, ON |
| 63 | Tue Mar 6 | vs Hawks | W106-90 | 46-17 | .730 | | Scotiabank Arena · Toronto, ON |
| 64 | Wed Mar 7 | at Pistons | W121-119 (OT) | 47-17 | .734 | ESPN | Little Caesars Arena · Detroit, MI |
| 65 | Fri Mar 9 | vs Rockets | W108-105 | 48-17 | .738 | | Scotiabank Arena · Toronto, ON |
| 66 | Sun Mar 11 | at Knicks | W132-106 | 49-17 | .742 | | Madison Square Garden · Manhattan, NY |
| 67 | Tue Mar 13 | at Nets | W116-102 | 50-17 | .746 | | Barclays Center · Brooklyn, NY |
| 68 | Thu Mar 15 | at Pacers | W106-99 | 51-17 | .750 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 69 | Fri Mar 16 | vs Mavericks | W122-115 (OT) | 52-17 | .754 | | Scotiabank Arena · Toronto, ON |
| 70 | Sun Mar 18 | vs Thunder | L125-132 | 52-18 | .743 | | Scotiabank Arena · Toronto, ON |
| 71 | Tue Mar 20 | at Magic | W93-86 | 53-18 | .746 | | Amway Center · Orlando, FL |
| 72 | Wed Mar 21 | at Cavaliers | L129-132 | 53-19 | .736 | ESPN | Rocket Mortgage FieldHouse · Cleveland, OH |
| 73 | Fri Mar 23 | vs Nets | W116-112 | 54-19 | .740 | | Scotiabank Arena · Toronto, ON |
| 74 | Sun Mar 25 | vs Clippers | L106-117 | 54-20 | .730 | | Scotiabank Arena · Toronto, ON |
| 75 | Tue Mar 27 | vs Nuggets | W114-110 | 55-20 | .733 | | Scotiabank Arena · Toronto, ON |
| 76 | Sat Mar 31 | at Celtics | L99-110 | 55-21 | .724 | NBA TV | TD Garden · Boston, MA |
| 77 | Tue Apr 3 | at Cavaliers | L106-112 | 55-22 | .714 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 78 | Wed Apr 4 | vs Celtics | W96-78 | 56-22 | .718 | ESPN | Scotiabank Arena · Toronto, ON |
| 79 | Fri Apr 6 | vs Pacers | W92-73 | 57-22 | .722 | | Scotiabank Arena · Toronto, ON |
| 80 | Sun Apr 8 | vs Magic | W112-101 | 58-22 | .725 | NBA TV | Scotiabank Arena · Toronto, ON |
| 81 | Mon Apr 9 | at Pistons | W108-98 | 59-22 | .728 | | Little Caesars Arena · Detroit, MI |
| 82 | Wed Apr 11 | at Heat | L109-116 (OT) | 59-23 | .720 | | Kaseya Center · Miami, FL |
| 1 | Sat Apr 14 | vs Wizards | W114-106 | 1-0 | 1.000 | ESPN | Scotiabank Arena · Toronto, ON |
| 2 | Tue Apr 17 | vs Wizards | W130-119 | 2-0 | 1.000 | NBA TV | Scotiabank Arena · Toronto, ON |
| 3 | Fri Apr 20 | at Wizards | L103-122 | 2-1 | .667 | ESPN2 | Capital One Arena · Washington, D.C. |
| 4 | Sun Apr 22 | at Wizards | L98-106 | 2-2 | .500 | TNT | Capital One Arena · Washington, D.C. |
| 5 | Wed Apr 25 | vs Wizards | W108-98 | 3-2 | .600 | NBA TV | Scotiabank Arena · Toronto, ON |
| 6 | Fri Apr 27 | at Wizards | W102-92 | 4-2 | .667 | ESPNews | Capital One Arena · Washington, D.C. |
| 1 | Tue May 1 | vs Cavaliers | L112-113 (OT) | 0-1 | .000 | TNT | Scotiabank Arena · Toronto, ON |
| 2 | Thu May 3 | vs Cavaliers | L110-128 | 0-2 | .000 | ESPN | Scotiabank Arena · Toronto, ON |
| 3 | Sat May 5 | at Cavaliers | L103-105 | 0-3 | .000 | ABC | Rocket Mortgage FieldHouse · Cleveland, OH |
| 4 | Mon May 7 | at Cavaliers | L93-128 | 0-4 | .000 | TNT | Rocket Mortgage FieldHouse · Cleveland, OH |