| 1 | Sun Sep 11 | at Jets | W24-9 | 1-0 | 1.000 | MetLife Stadium · East Rutherford, NJ |
| 2 | Sun Sep 18 | vs Dolphins | L38-42 | 1-1 | .500 | M&T Bank Stadium · Baltimore, MD |
| 3 | Sun Sep 25 | at Patriots | W37-26 | 2-1 | .667 | Gillette Stadium · Foxborough, MA |
| 4 | Sun Oct 2 | vs Bills | L20-23 | 2-2 | .500 | M&T Bank Stadium · Baltimore, MD |
| 5 | Sun Oct 9 | vs Bengals | W19-17 | 3-2 | .600 | M&T Bank Stadium · Baltimore, MD |
| 6 | Sun Oct 16 | at Giants | L20-24 | 3-3 | .500 | MetLife Stadium · East Rutherford, NJ |
| 7 | Sun Oct 23 | vs Browns | W23-20 | 4-3 | .571 | M&T Bank Stadium · Baltimore, MD |
| 8 | Thu Oct 27 | at Buccaneers | W27-22 | 5-3 | .625 | Raymond James Stadium · Tampa, FL |
| 9 | Mon Nov 7 | at Saints | W27-13 | 6-3 | .667 | Caesars Superdome · New Orleans, LA |
| 10 | -- BYE WEEK -- |
| 11 | Sun Nov 20 | vs Panthers | W13-3 | 7-3 | .700 | M&T Bank Stadium · Baltimore, MD |
| 12 | Sun Nov 27 | at Jaguars | L27-28 | 7-4 | .636 | TIAA Bank Field · Jacksonville, FL |
| 13 | Sun Dec 4 | vs Broncos | W10-9 | 8-4 | .667 | M&T Bank Stadium · Baltimore, MD |
| 14 | Sun Dec 11 | at Steelers | W16-14 | 9-4 | .692 | Acrisure Stadium · Pittsburgh, PA |
| 15 | Sat Dec 17 | atBrowns | L3-13 | 9-5 | .643 | FirstEnergy Stadium · Cleveland, OH |
| 16 | Sat Dec 24 | vs Falcons | W17-9 | 10-5 | .667 | M&T Bank Stadium · Baltimore, MD |
| 17 | Sun Jan 1 | vsSteelers | L13-16 | 10-6 | .625 | M&T Bank Stadium · Baltimore, MD |
| 18 | Sun Jan 8 | atBengals | L16-27 | 10-7 | .588 | Paycor Stadium · Cincinnati, OH |
| WC | Sun Jan 15 | atBengals | L17-24 | 10-7 | .588 | Paycor Stadium · Cincinnati, OH |
