| 1 | Sun Sep 7 | at Bills | L40-41 | 0-1 | .000 | Highmark Stadium · Orchard Park, NY |
| 2 | Sun Sep 14 | vsBrowns | W41-17 | 1-1 | .500 | M&T Bank Stadium · Baltimore, MD |
| 3 | Mon Sep 22 | vsLions | L30-38 | 1-2 | .333 | M&T Bank Stadium · Baltimore, MD |
| 4 | Sun Sep 28 | atChiefs | L20-37 | 1-3 | .250 | Arrowhead Stadium · Kansas City, MO |
| 5 | Sun Oct 5 | vsTexans | L10-44 | 1-4 | .200 | M&T Bank Stadium · Baltimore, MD |
| 6 | Sun Oct 12 | vsRams | L3-17 | 1-5 | .167 | M&T Bank Stadium · Baltimore, MD |
| --bye week-- |
| 8 | Sun Oct 26 | vsBears | W30-16 | 2-5 | .286 | M&T Bank Stadium · Baltimore, MD |
| 9 | Thu Oct 30 | atDolphins | W28-6 | 3-5 | .375 | Hard Rock Stadium · Miami Gardens, FL |
| 10 | Sun Nov 9 | atVikings | W27-19 | 4-5 | .444 | U.S. Bank Stadium · Minneapolis, MN |
| 11 | Sun Nov 16 | atBrowns | W23-16 | 5-5 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Sun Nov 23 | vsJets | W23-10 | 6-5 | .545 | M&T Bank Stadium · Baltimore, MD |
| 13 | Thu Nov 27 | vsBengals | L14-32 | 6-6 | .500 | M&T Bank Stadium · Baltimore, MD |
| 14 | Sun Dec 7 | vsSteelers | L22-27 | 6-7 | .462 | M&T Bank Stadium · Baltimore, MD |
| 15 | Sun Dec 14 | atBengals | W24-0 | 7-7 | .500 | Paycor Stadium · Cincinnati, OH |
| 16 | Sun Dec 21 | vsPatriots | L24-28 | 7-8 | .467 | M&T Bank Stadium · Baltimore, MD |
| 17 | Sat Dec 27 | atPackers | W41-24 | 8-8 | .500 | Lambeau Field · Green Bay, WI |
| 18 | Sun Jan 4 | atSteelers | L24-26 | 8-9 | .471 | Acrisure Stadium · Pittsburgh, PA |
