| 1 | Mon Sep 13 | at Raiders | L27-33 (OT) | 0-1 | .000 | Allegiant Stadium · Las Vegas, NV |
| 2 | Sun Sep 19 | vs Chiefs | W36-35 | 1-1 | .500 | M&T Bank Stadium · Baltimore, MD |
| 3 | Sun Sep 26 | at Lions | W19-17 | 2-1 | .667 | Ford Field · Detroit, MI |
| 4 | Sun Oct 3 | at Broncos | W23-7 | 3-1 | .750 | Empower Field at Mile High · Denver, CO |
| 5 | Mon Oct 11 | vs Colts | W31-25 (OT) | 4-1 | .800 | M&T Bank Stadium · Baltimore, MD |
| 6 | Sun Oct 17 | vs Chargers | W34-6 | 5-1 | .833 | M&T Bank Stadium · Baltimore, MD |
| 7 | Sun Oct 24 | vs Bengals | L17-41 | 5-2 | .714 | M&T Bank Stadium · Baltimore, MD |
| 8 | -- BYE WEEK -- |
| 9 | Sun Nov 7 | vs Vikings | W34-31 (OT) | 6-2 | .750 | M&T Bank Stadium · Baltimore, MD |
| 10 | Thu Nov 11 | at Dolphins | L10-22 | 6-3 | .667 | Hard Rock Stadium · Miami Gardens, FL |
| 11 | Sun Nov 21 | at Bears | W16-13 | 7-3 | .700 | Soldier Field · Chicago, IL |
| 12 | Sun Nov 28 | vs Browns | W16-10 | 8-3 | .727 | M&T Bank Stadium · Baltimore, MD |
| 13 | Sun Dec 5 | at Steelers | L19-20 | 8-4 | .667 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Sun Dec 12 | atBrowns | L22-24 | 8-5 | .615 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Sun Dec 19 | vs Packers | L30-31 | 8-6 | .571 | M&T Bank Stadium · Baltimore, MD |
| 16 | Sun Dec 26 | atBengals | L21-41 | 8-7 | .533 | Paycor Stadium · Cincinnati, OH |
| 17 | Sun Jan 2 | vs Rams | L19-20 | 8-8 | .500 | M&T Bank Stadium · Baltimore, MD |
| 18 | Sun Jan 9 | vsSteelers | L13-16 (OT) | 8-9 | .471 | M&T Bank Stadium · Baltimore, MD |
