| 1 | Sun Sep 13 | vs Browns | W38-6 | 1-0 | 1.000 | M&T Bank Stadium · Baltimore, MD |
| 2 | Sun Sep 20 | atTexans | W33-16 | 2-0 | 1.000 | NRG Stadium · Houston, TX |
| 3 | Mon Sep 28 | vsChiefs | L20-34 | 2-1 | .667 | M&T Bank Stadium · Baltimore, MD |
| 4 | Sun Oct 4 | atCommanders | W31-17 | 3-1 | .750 | FedEx Field · North Englewood, MD |
| 5 | Sun Oct 11 | vsBengals | W27-3 | 4-1 | .800 | M&T Bank Stadium · Baltimore, MD |
| 6 | Sun Oct 18 | atEagles | W30-28 | 5-1 | .833 | Lincoln Financial Field · Philadelphia, PA |
| --bye week-- |
| 8 | Sun Nov 1 | vsSteelers | L24-28 | 5-2 | .714 | M&T Bank Stadium · Baltimore, MD |
| 9 | Sun Nov 8 | atColts | W24-10 | 6-2 | .750 | Lucas Oil Stadium · Indianapolis, IN |
| 10 | Sun Nov 15 | atPatriots | L17-23 | 6-3 | .667 | Gillette Stadium · Foxborough, MA |
| 11 | Sun Nov 22 | vsTitans | L24-30 (OT) | 6-4 | .600 | M&T Bank Stadium · Baltimore, MD |
| 12 | Wed Dec 2 | atSteelers | L14-19 | 6-5 | .545 | Acrisure Stadium · Pittsburgh, PA |
| 13 | Tue Dec 8 | vsCowboys | W34-17 | 7-5 | .583 | M&T Bank Stadium · Baltimore, MD |
| 14 | Mon Dec 14 | atBrowns | W47-42 | 8-5 | .615 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Sun Dec 20 | vsJaguars | W40-14 | 9-5 | .643 | M&T Bank Stadium · Baltimore, MD |
| 16 | Sun Dec 27 | vsGiants | W27-13 | 10-5 | .667 | M&T Bank Stadium · Baltimore, MD |
| 17 | Sun Jan 3 | atBengals | W38-3 | 11-5 | .688 | Paycor Stadium · Cincinnati, OH |
| WC | Sun Jan 10 | atTitans | W20-13 | 11-5 | .688 | Nissan Stadium · Nashville, TN |
| DIV | Sat Jan 16 | atBills | L3-17 | 11-5 | .688 | Highmark Stadium · Orchard Park, NY |
