| 1 | Sun Sep 8 | vs Rams | L27-30 | - | 0-1 | .000 | Bank of America Stadium · Charlotte, NC |
| 2 | Thu Sep 12 | vsBuccaneers | L14-20 | - | 0-2 | .000 | Bank of America Stadium · Charlotte, NC |
| 3 | Sun Sep 22 | atCardinals | W38-20 | - | 1-2 | .333 | State Farm Stadium · Glendale, AZ |
| 4 | Sun Sep 29 | atTexans | W16-10 | - | 2-2 | .500 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 6 | vsJaguars | W34-27 | - | 3-2 | .600 | Bank of America Stadium · Charlotte, NC |
| 6 | Sun Oct 13 | atBuccaneers | W37-26 | - | 4-2 | .667 | Tottenham Hotspur Stadium · London, England |
| --bye week-- |
| 8 | Sun Oct 27 | at49ers | L13-51 | - | 4-3 | .571 | Levi's® Stadium · Santa Clara, CA |
| 9 | Sun Nov 3 | vsTitans | W30-20 | - | 5-3 | .625 | Bank of America Stadium · Charlotte, NC |
| 10 | Sun Nov 10 | atPackers | L16-24 | - | 5-4 | .556 | Lambeau Field · Green Bay, WI |
| 11 | Sun Nov 17 | vsFalcons | L3-29 | - | 5-5 | .500 | Bank of America Stadium · Charlotte, NC |
| 12 | Sun Nov 24 | atSaints | L31-34 | - | 5-6 | .455 | Caesars Superdome · New Orleans, LA |
| 13 | Sun Dec 1 | vsCommanders | L21-29 | - | 5-7 | .417 | Bank of America Stadium · Charlotte, NC |
| 14 | Sun Dec 8 | atFalcons | L20-40 | - | 5-8 | .385 | Mercedes-Benz Stadium · Atlanta, GA |
| 15 | Sun Dec 15 | vsSeahawks | L24-30 | - | 5-9 | .357 | Bank of America Stadium · Charlotte, NC |
| 16 | Sun Dec 22 | atColts | L6-38 | - | 5-10 | .333 | Lucas Oil Stadium · Indianapolis, IN |
| 17 | Sun Dec 29 | vsSaints | L10-42 | - | 5-11 | .313 | Bank of America Stadium · Charlotte, NC |
