| 1 | Sun Sep 12 | vs Jets | W19-14 | - | 1-0 | 1.000 | Bank of America Stadium · Charlotte, NC |
| 2 | Sun Sep 19 | vsSaints | W26-7 | - | 2-0 | 1.000 | Bank of America Stadium · Charlotte, NC |
| 3 | Thu Sep 23 | atTexans | W24-9 | - | 3-0 | 1.000 | NRG Stadium · Houston, TX |
| 4 | Sun Oct 3 | atCowboys | L28-36 | - | 3-1 | .750 | AT&T Stadium · Arlington, TX |
| 5 | Sun Oct 10 | vsEagles | L18-21 | - | 3-2 | .600 | Bank of America Stadium · Charlotte, NC |
| 6 | Sun Oct 17 | vsVikings | L28-34 (OT) | - | 3-3 | .500 | Bank of America Stadium · Charlotte, NC |
| 7 | Sun Oct 24 | atGiants | L3-25 | - | 3-4 | .429 | MetLife Stadium · East Rutherford, NJ |
| 8 | Sun Oct 31 | atFalcons | W19-13 | - | 4-4 | .500 | Mercedes-Benz Stadium · Atlanta, GA |
| 9 | Sun Nov 7 | vsPatriots | L6-24 | - | 4-5 | .444 | Bank of America Stadium · Charlotte, NC |
| 10 | Sun Nov 14 | atCardinals | W34-10 | - | 5-5 | .500 | State Farm Stadium · Glendale, AZ |
| 11 | Sun Nov 21 | vsCommanders | L21-27 | - | 5-6 | .455 | Bank of America Stadium · Charlotte, NC |
| 12 | Sun Nov 28 | atDolphins | L10-33 | - | 5-7 | .417 | Hard Rock Stadium · Miami Gardens, FL |
| --bye week-- |
| 14 | Sun Dec 12 | vsFalcons | L21-29 | - | 5-8 | .385 | Bank of America Stadium · Charlotte, NC |
| 15 | Sun Dec 19 | atBills | L14-31 | - | 5-9 | .357 | Highmark Stadium · Orchard Park, NY |
| 16 | Sun Dec 26 | vsBuccaneers | L6-32 | - | 5-10 | .333 | Bank of America Stadium · Charlotte, NC |
| 17 | Sun Jan 2 | atSaints | L10-18 | - | 5-11 | .313 | Caesars Superdome · New Orleans, LA |
| 18 | Sun Jan 9 | atBuccaneers | L17-41 | - | 5-12 | .294 | Raymond James Stadium · Tampa, FL |
