| 1 | Sun Sep 10 | at Falcons | L10-24 | - | 0-1 | .000 | Mercedes-Benz Stadium · Atlanta, GA |
| 2 | Mon Sep 18 | vsSaints | L17-20 | - | 0-2 | .000 | Bank of America Stadium · Charlotte, NC |
| 3 | Sun Sep 24 | atSeahawks | L27-37 | - | 0-3 | .000 | Lumen Field · Seattle, WA |
| 4 | Sun Oct 1 | vsVikings | L13-21 | - | 0-4 | .000 | Bank of America Stadium · Charlotte, NC |
| 5 | Sun Oct 8 | atLions | L24-42 | - | 0-5 | .000 | Ford Field · Detroit, MI |
| 6 | Sun Oct 15 | atDolphins | L21-42 | - | 0-6 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| --bye week-- |
| 8 | Sun Oct 29 | vsTexans | W15-13 | - | 1-6 | .143 | Bank of America Stadium · Charlotte, NC |
| 9 | Sun Nov 5 | vsColts | L13-27 | - | 1-7 | .125 | Bank of America Stadium · Charlotte, NC |
| 10 | Thu Nov 9 | atBears | L13-16 | - | 1-8 | .111 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 19 | vsCowboys | L10-33 | - | 1-9 | .100 | Bank of America Stadium · Charlotte, NC |
| 12 | Sun Nov 26 | atTitans | L10-17 | - | 1-10 | .091 | Nissan Stadium · Nashville, TN |
| 13 | Sun Dec 3 | atBuccaneers | L18-21 | - | 1-11 | .083 | Raymond James Stadium · Tampa, FL |
| 14 | Sun Dec 10 | atSaints | L6-28 | - | 1-12 | .077 | Caesars Superdome · New Orleans, LA |
| 15 | Sun Dec 17 | vsFalcons | W9-7 | - | 2-12 | .143 | Bank of America Stadium · Charlotte, NC |
| 16 | Sun Dec 24 | vsPackers | L30-33 | - | 2-13 | .133 | Bank of America Stadium · Charlotte, NC |
| 17 | Sun Dec 31 | atJaguars | L0-26 | - | 2-14 | .125 | TIAA Bank Field · Jacksonville, FL |
| 18 | Sun Jan 7 | vsBuccaneers | L0-9 | - | 2-15 | .118 | Bank of America Stadium · Charlotte, NC |
