| 1 | Sun Sep 13 | vs Raiders | L30-34 | - | 0-1 | .000 | Bank of America Stadium · Charlotte, NC |
| 2 | Sun Sep 20 | atBuccaneers | L17-31 | - | 0-2 | .000 | Raymond James Stadium · Tampa, FL |
| 3 | Sun Sep 27 | atChargers | W21-16 | - | 1-2 | .333 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Oct 4 | vsCardinals | W31-21 | - | 2-2 | .500 | Bank of America Stadium · Charlotte, NC |
| 5 | Sun Oct 11 | atFalcons | W23-16 | - | 3-2 | .600 | Mercedes-Benz Stadium · Atlanta, GA |
| 6 | Sun Oct 18 | vsBears | L16-23 | - | 3-3 | .500 | Bank of America Stadium · Charlotte, NC |
| 7 | Sun Oct 25 | atSaints | L24-27 | - | 3-4 | .429 | Caesars Superdome · New Orleans, LA |
| 8 | Thu Oct 29 | vsFalcons | L17-25 | - | 3-5 | .375 | Bank of America Stadium · Charlotte, NC |
| 9 | Sun Nov 8 | atChiefs | L31-33 | - | 3-6 | .333 | Arrowhead Stadium · Kansas City, MO |
| 10 | Sun Nov 15 | vsBuccaneers | L23-46 | - | 3-7 | .300 | Bank of America Stadium · Charlotte, NC |
| 11 | Sun Nov 22 | vsLions | W20-0 | - | 4-7 | .364 | Bank of America Stadium · Charlotte, NC |
| 12 | Sun Nov 29 | atVikings | L27-28 | - | 4-8 | .333 | U.S. Bank Stadium · Minneapolis, MN |
| --bye week-- |
| 14 | Sun Dec 13 | vsBroncos | L27-32 | - | 4-9 | .308 | Bank of America Stadium · Charlotte, NC |
| 15 | Sat Dec 19 | atPackers | L16-24 | - | 4-10 | .286 | Lambeau Field · Green Bay, WI |
| 16 | Sun Dec 27 | atCommanders | W20-13 | - | 5-10 | .333 | FedEx Field · North Englewood, MD |
| 17 | Sun Jan 3 | vsSaints | L7-33 | - | 5-11 | .313 | Bank of America Stadium · Charlotte, NC |
