| 1 | Sun Sep 11 | vs Browns | L24-26 | 0-1 | .000 | Bank of America Stadium · Charlotte, NC |
| 2 | Sun Sep 18 | at Giants | L16-19 | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 3 | Sun Sep 25 | vs Saints | W22-14 | 1-2 | .333 | Bank of America Stadium · Charlotte, NC |
| 4 | Sun Oct 2 | vs Cardinals | L16-26 | 1-3 | .250 | Bank of America Stadium · Charlotte, NC |
| 5 | Sun Oct 9 | vs 49ers | L15-37 | 1-4 | .200 | Bank of America Stadium · Charlotte, NC |
| 6 | Sun Oct 16 | at Rams | L10-24 | 1-5 | .167 | SoFi Stadium · Inglewood, CA |
| 7 | Sun Oct 23 | vs Buccaneers | W21-3 | 2-5 | .286 | Bank of America Stadium · Charlotte, NC |
| 8 | Sun Oct 30 | at Falcons | L34-37 (OT) | 2-6 | .250 | Mercedes-Benz Stadium · Atlanta, GA |
| 9 | Sun Nov 6 | at Bengals | L21-42 | 2-7 | .222 | Paycor Stadium · Cincinnati, OH |
| 10 | Thu Nov 10 | vsFalcons | W25-15 | 3-7 | .300 | Bank of America Stadium · Charlotte, NC |
| 11 | Sun Nov 20 | at Ravens | L3-13 | 3-8 | .273 | M&T Bank Stadium · Baltimore, MD |
| 12 | Sun Nov 27 | vs Broncos | W23-10 | 4-8 | .333 | Bank of America Stadium · Charlotte, NC |
| 13 | -- BYE WEEK -- |
| 14 | Sun Dec 11 | at Seahawks | W30-24 | 5-8 | .385 | Lumen Field · Seattle, WA |
| 15 | Sun Dec 18 | vs Steelers | L16-24 | 5-9 | .357 | Bank of America Stadium · Charlotte, NC |
| 16 | Sat Dec 24 | vs Lions | W37-23 | 6-9 | .400 | Bank of America Stadium · Charlotte, NC |
| 17 | Sun Jan 1 | atBuccaneers | L24-30 | 6-10 | .375 | Raymond James Stadium · Tampa, FL |
| 18 | Sun Jan 8 | atSaints | W10-7 | 7-10 | .412 | Caesars Superdome · New Orleans, LA |
