| 1 | Sun Sep 8 | at Saints | L10-47 | - | 0-1 | .000 | Caesars Superdome · New Orleans, LA |
| 2 | Sun Sep 15 | vsChargers | L3-26 | - | 0-2 | .000 | Bank of America Stadium · Charlotte, NC |
| 3 | Sun Sep 22 | atRaiders | W36-22 | - | 1-2 | .333 | Allegiant Stadium · Las Vegas, NV |
| 4 | Sun Sep 29 | vsBengals | L24-34 | - | 1-3 | .250 | Bank of America Stadium · Charlotte, NC |
| 5 | Sun Oct 6 | atBears | L10-36 | - | 1-4 | .200 | Soldier Field · Chicago, IL |
| 6 | Sun Oct 13 | vsFalcons | L20-38 | - | 1-5 | .167 | Bank of America Stadium · Charlotte, NC |
| 7 | Sun Oct 20 | atCommanders | L7-40 | - | 1-6 | .143 | FedEx Field · North Englewood, MD |
| 8 | Sun Oct 27 | atBroncos | L14-28 | - | 1-7 | .125 | Empower Field at Mile High · Denver, CO |
| 9 | Sun Nov 3 | vsSaints | W23-22 | - | 2-7 | .222 | Bank of America Stadium · Charlotte, NC |
| 10 | Sun Nov 10 | vsGiants | W20-17 (OT) | - | 3-7 | .300 | Allianz Arena · Munich, Germany |
| --bye week-- |
| 12 | Sun Nov 24 | vsChiefs | L27-30 | - | 3-8 | .273 | Bank of America Stadium · Charlotte, NC |
| 13 | Sun Dec 1 | vsBuccaneers | L23-26 (OT) | - | 3-9 | .250 | Bank of America Stadium · Charlotte, NC |
| 14 | Sun Dec 8 | atEagles | L16-22 | - | 3-10 | .231 | Lincoln Financial Field · Philadelphia, PA |
| 15 | Sun Dec 15 | vsCowboys | L14-30 | - | 3-11 | .214 | Bank of America Stadium · Charlotte, NC |
| 16 | Sun Dec 22 | vsCardinals | W36-30 (OT) | - | 4-11 | .267 | Bank of America Stadium · Charlotte, NC |
| 17 | Sun Dec 29 | atBuccaneers | L14-48 | - | 4-12 | .250 | Raymond James Stadium · Tampa, FL |
| 18 | Sun Jan 5 | atFalcons | W44-38 (OT) | - | 5-12 | .294 | Mercedes-Benz Stadium · Atlanta, GA |
