| 1 | Sun Sep 7 | at Jaguars | L10-26 | - | 0-1 | .000 | TIAA Bank Field · Jacksonville, FL |
| 2 | Sun Sep 14 | atCardinals | L22-27 | - | 0-2 | .000 | State Farm Stadium · Glendale, AZ |
| 3 | Sun Sep 21 | vsFalcons | W30-0 | - | 1-2 | .333 | Bank of America Stadium · Charlotte, NC |
| 4 | Sun Sep 28 | atPatriots | L13-42 | - | 1-3 | .250 | Gillette Stadium · Foxborough, MA |
| 5 | Sun Oct 5 | vsDolphins | W27-24 | - | 2-3 | .400 | Bank of America Stadium · Charlotte, NC |
| 6 | Sun Oct 12 | vsCowboys | W30-27 | - | 3-3 | .500 | Bank of America Stadium · Charlotte, NC |
| 7 | Sun Oct 19 | atJets | W13-6 | - | 4-3 | .571 | MetLife Stadium · East Rutherford, NJ |
| 8 | Sun Oct 26 | vsBills | L9-40 | - | 4-4 | .500 | Bank of America Stadium · Charlotte, NC |
| 9 | Sun Nov 2 | atPackers | W16-13 | - | 5-4 | .556 | Lambeau Field · Green Bay, WI |
| 10 | Sun Nov 9 | vsSaints | L7-17 | - | 5-5 | .500 | Bank of America Stadium · Charlotte, NC |
| 11 | Sun Nov 16 | atFalcons | W30-27 (OT) | - | 6-5 | .545 | Mercedes-Benz Stadium · Atlanta, GA |
| 12 | Mon Nov 24 | at49ers | L9-20 | - | 6-6 | .500 | Levi's® Stadium · Santa Clara, CA |
| 13 | Sun Nov 30 | vsRams | W31-28 | - | 7-6 | .538 | Bank of America Stadium · Charlotte, NC |
| --bye week-- |
| 15 | Sun Dec 14 | atSaints | L17-20 | - | 7-7 | .500 | Caesars Superdome · New Orleans, LA |
| 16 | Sun Dec 21 | vsBuccaneers | W23-20 | - | 8-7 | .533 | Bank of America Stadium · Charlotte, NC |
| 17 | Sun Dec 28 | vsSeahawks | L10-27 | - | 8-8 | .500 | Bank of America Stadium · Charlotte, NC |
| 18 | Sat Jan 3 | atBuccaneers | L14-16 | - | 8-9 | .471 | Raymond James Stadium · Tampa, FL |
| WC | Sat Jan 10 | vsRams | L31-34 | - | 8-9 | .471 | Bank of America Stadium · Charlotte, NC |
