| 4 | Sun Sep 28 | at Patriots | 1:00 PM | 1-2 | .333 | Gillette Stadium · Foxborough, MA |
| 5 | Sun Oct 5 | vsDolphins | 1:00 PM | 0-3 | .000 | Bank of America Stadium · Charlotte, NC |
| 6 | Sun Oct 12 | vsCowboys | 1:00 PM | 1-2 | .333 | Bank of America Stadium · Charlotte, NC |
| 7 | Sun Oct 19 | atJets | 1:00 PM | 0-3 | .000 | MetLife Stadium · East Rutherford, NJ |
| 8 | Sun Oct 26 | vsBills | 1:00 PM | 3-0 | 1.000 | Bank of America Stadium · Charlotte, NC |
| 9 | Sun Nov 2 | atPackers | 1:00 PM | 2-1 | .667 | Lambeau Field · Green Bay, WI |
| 10 | Sun Nov 9 | vsSaints | 1:00 PM | 0-3 | .000 | Bank of America Stadium · Charlotte, NC |
| 11 | Sun Nov 16 | atFalcons | 1:00 PM | 1-2 | .333 | Mercedes-Benz Stadium · Atlanta, GA |
| 12 | Mon Nov 24 | at49ers | 8:15 PM | 3-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 13 | Sun Nov 30 | vsRams | 1:00 PM | 2-1 | .667 | Bank of America Stadium · Charlotte, NC |
| --bye week-- |
| 15 | Sun Dec 14 | atSaints | 4:25 PM | 0-3 | .000 | Caesars Superdome · New Orleans, LA |
| 16 | Sun Dec 21 | vsBuccaneers | 1:00 PM | 3-0 | 1.000 | Bank of America Stadium · Charlotte, NC |
| 17 | TBD | vsSeahawks | TBD | 3-1 | .750 | Bank of America Stadium · Charlotte, NC |
| 18 | TBD | atBuccaneers | TBD | 3-0 | 1.000 | Raymond James Stadium · Tampa, FL |
