| 1 | Sun Sep 13 | vs Browns | 1:00 PM | 0-0 | .000 | TIAA Bank Field · Jacksonville, FL |
| 2 | Sun Sep 20 | atBroncos | 4:05 PM | 0-0 | .000 | Empower Field at Mile High · Denver, CO |
| 3 | Sun Sep 27 | vsPatriots | 1:00 PM | 0-0 | .000 | TIAA Bank Field · Jacksonville, FL |
| 4 | Sun Oct 4 | atBengals | 1:00 PM | 0-0 | .000 | Paycor Stadium · Cincinnati, OH |
| 5 | Sun Oct 11 | vsEagles | 9:30 AM | 0-0 | .000 | Tottenham Hotspur Stadium · London, England |
| 6 | Sun Oct 18 | vsTexans | 9:30 AM | 0-0 | .000 | Wembley Stadium · London, England |
| --bye week-- |
| 8 | Sun Nov 1 | vsColts | 1:00 PM | 0-0 | .000 | TIAA Bank Field · Jacksonville, FL |
| 9 | Thu Nov 5 | atRavens | 8:15 PM | 0-0 | .000 | M&T Bank Stadium · Baltimore, MD |
| 10 | Sun Nov 15 | atTitans | 1:00 PM | 0-0 | .000 | Nissan Stadium · Nashville, TN |
| 11 | Sun Nov 22 | atGiants | 1:00 PM | 0-0 | .000 | MetLife Stadium · East Rutherford, NJ |
| 12 | Sun Nov 29 | vsTitans | 4:05 PM | 0-0 | .000 | TIAA Bank Field · Jacksonville, FL |
| 13 | Sun Dec 6 | atBears | 1:00 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 14 | Mon Dec 14 | vsSteelers | 8:15 PM | 0-0 | .000 | TIAA Bank Field · Jacksonville, FL |
| 15 | Sun Dec 20 | atTexans | 1:00 PM | 0-0 | .000 | NRG Stadium · Houston, TX |
| 16 | Sun Dec 27 | atCowboys | 8:20 PM | 0-0 | .000 | AT&T Stadium · Arlington, TX |
| 17 | TBD | vsCommanders | TBD | 0-0 | .000 | TIAA Bank Field · Jacksonville, FL |
| 18 | TBD | atColts | TBD | 0-0 | .000 | Lucas Oil Stadium · Indianapolis, IN |
