| 1 | Sun Sep 13 | at Falcons | W38-25 | 0-0 | .000 | Mercedes-Benz Stadium · Atlanta, GA |
| 2 | Sun Sep 20 | vs Patriots | W35-30 | 2-0 | 1.000 | Lumen Field · Seattle, WA |
| 3 | Sun Sep 27 | vs Cowboys | W38-31 | 3-0 | 1.000 | Lumen Field · Seattle, WA |
| 4 | Sun Oct 4 | at Dolphins | W31-23 | 4-0 | 1.000 | Hard Rock Stadium · Miami Gardens, FL |
| 5 | Sun Oct 11 | vs Vikings | W27-26 | 5-0 | 1.000 | Lumen Field · Seattle, WA |
| 6 | -- BYE WEEK -- |
| 7 | Sun Oct 25 | at Cardinals | L34-37 (OT) | 5-1 | .833 | State Farm Stadium · Glendale, AZ |
| 8 | Sun Nov 1 | vs 49ers | W37-27 | 6-1 | .857 | Lumen Field · Seattle, WA |
| 9 | Sun Nov 8 | at Bills | L34-44 | 6-2 | .750 | Highmark Stadium · Orchard Park, NY |
| 10 | Sun Nov 15 | at Rams | L16-23 | 6-3 | .667 | SoFi Stadium · Inglewood, CA |
| 11 | Thu Nov 19 | vsCardinals | W28-21 | 7-3 | .700 | Lumen Field · Seattle, WA |
| 12 | Mon Nov 30 | at Eagles | W23-17 | 8-3 | .727 | Lincoln Financial Field · Philadelphia, PA |
| 13 | Sun Dec 6 | vs Giants | L12-17 | 8-4 | .667 | Lumen Field · Seattle, WA |
| 14 | Sun Dec 13 | vs Jets | W40-3 | 9-4 | .692 | Lumen Field · Seattle, WA |
| 15 | Sun Dec 20 | at Commanders | W20-15 | 10-4 | .714 | FedEx Field · North Englewood, MD |
| 16 | Sun Dec 27 | vsRams | W20-9 | 11-4 | .733 | Lumen Field · Seattle, WA |
| 17 | Sun Jan 3 | at49ers | W26-23 | 12-4 | .750 | State Farm Stadium · Glendale, AZ |
| WC | Sat Jan 9 | vsRams | L20-30 | 12-4 | .750 | Lumen Field · Seattle, WA |
