| 1 | Sun Sep 12 | at Colts | W28-16 | 1-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 2 | Sun Sep 19 | vsTitans | L30-33 (OT) | 1-1 | .500 | Lumen Field · Seattle, WA |
| 3 | Sun Sep 26 | atVikings | L17-30 | 1-2 | .333 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Oct 3 | at49ers | W28-21 | 2-2 | .500 | Levi's® Stadium · Santa Clara, CA |
| 5 | Thu Oct 7 | vsRams | L17-26 | 2-3 | .400 | Lumen Field · Seattle, WA |
| 6 | Sun Oct 17 | atSteelers | L20-23 (OT) | 2-4 | .333 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Mon Oct 25 | vsSaints | L10-13 | 2-5 | .286 | Lumen Field · Seattle, WA |
| 8 | Sun Oct 31 | vsJaguars | W31-7 | 3-5 | .375 | Lumen Field · Seattle, WA |
| --bye week-- |
| 10 | Sun Nov 14 | atPackers | L0-17 | 3-6 | .333 | Lambeau Field · Green Bay, WI |
| 11 | Sun Nov 21 | vsCardinals | L13-23 | 3-7 | .300 | Lumen Field · Seattle, WA |
| 12 | Mon Nov 29 | atCommanders | L15-17 | 3-8 | .273 | FedEx Field · North Englewood, MD |
| 13 | Sun Dec 5 | vs49ers | W30-23 | 4-8 | .333 | Lumen Field · Seattle, WA |
| 14 | Sun Dec 12 | atTexans | W33-13 | 5-8 | .385 | NRG Stadium · Houston, TX |
| 15 | Tue Dec 21 | atRams | L10-20 | 5-9 | .357 | SoFi Stadium · Inglewood, CA |
| 16 | Sun Dec 26 | vsBears | L24-25 | 5-10 | .333 | Lumen Field · Seattle, WA |
| 17 | Sun Jan 2 | vsLions | W51-29 | 6-10 | .375 | Lumen Field · Seattle, WA |
| 18 | Sun Jan 9 | atCardinals | W38-30 | 7-10 | .412 | State Farm Stadium · Glendale, AZ |
